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university of tampere: faculty of medicine and life sciences: research: katriina aalto-setälä - heart group:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Katriina Aalto-Setälä - Heart Group

Previous publications

Vanninen SUM, Nikus K, Aalto-Setälä K
Electrocardiogram changes and atrial arrhythmias in individuals carrying sodium channel SCN5A D1275N mutation.
Ann Med ;49(6)496-503, 2017

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setälä K
Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes.
Biol Open ;6(6)777-784, 2017

Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setälä K
Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct.
Cytotechnology ;69(5)785-800, 2017

Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K
Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.
Dis Model Mech ;10(9)1141-1153, 2017

Kuusela J, Kim J, Räsänen E, Aalto-Setälä K
The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.
Stem Cell Rev ;12(6)698-707, 2016

Paavola J, Väänänen H, Larsson K, Penttinen K, Toivonen L, Kontula K, Laine M, Aalto-Setälä K, Swan H, Viitasalo M
Slowed depolarization and irregular repolarization in catecholaminergic polymorphic ventricular tachycardia: a study from cellular Ca2+ transients and action potentials to clinical monophasic action potentials and electrocardiography.
Europace ;18(10)1599-1607, 2016

Joutsijoki H, Haponen M, Rasku J, Aalto-Setälä K, Juhola M
Machine Learning Approach to Automated Quality Identification of Human Induced Pluripotent Stem Cell Colony Images.
Comput Math Methods Med ;2016

Laurila E, Ahola A, Hyttinen J, Aalto-Setälä K
Methods for in vitro functional analysis of iPSC derived cardiomyocytes - Special focus on analyzing the mechanical beating behavior.
Biochim Biophys Acta ;1863(7 Pt B)1864-72, 2016

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setälä K
Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes.
Springerplus ;2016

Joutsijoki H, Haponen M, Rasku J, Aalto-Setälä K, Juhola M
Error-Correcting Output Codes in Classification of Human Induced Pluripotent Stem Cell Colony Images.
Biomed Res Int ;2016

Ojala M, Prajapati C, Pölönen RP, Rajala K, Pekkanen-Mattila M, Rasku J, Larsson K, Aalto-Setälä K
Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy.
Stem Cells Int ;2016

Manzini S, Viiri LE, Marttila S, Aalto-Setälä K
A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production.
Stem Cell Rev ;11(6)900-8, 2015

Kartasalo K, Pölönen RP, Ojala M, Rasku J, Lekkala J, Aalto-Setälä K, Kallio P
CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels.
BMC Bioinformatics ;2015

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.
PLoS One ;10(5)e0125366, 2015

Kiviaho AL, Ahola A, Larsson K, Penttinen K, Swan H, Pekkanen-Mattila M, Venäläinen H, Paavola K, Hyttinen J, Aalto-Setälä K
Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations.
Int J Cardiol Heart Vasc ;2015

Penttinen K, Siirtola H, Àvalos-Salguero J, Vainio T, Juhola M, Aalto-Setälä K
Novel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes.
PLoS One ;10(8)e0135806, 2015

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K
Correction: Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.
PLoS One ;10(7)e0134746, 2015

Juhola M, Penttinen K, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Siirtola H, Iltanen K, Laurikkala J, Hyyrö H, Hyttinen J, Aalto-Setälä K
Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes.
Comput Biol Med ;2015

Kreutzer J, Ikonen L, Hirvonen J, Pekkanen-Mattila M, Aalto-Setälä K, Kallio P
Pneumatic cell stretching system for cardiac differentiation and culture.
Med Eng Phys ;36(4)496-501, 2014

Gizatdinova Y, Rasku J, Haponen M, Joutsijoki H, Baldin I, Paci M, Hyttinen J, Aalto-Setälä K, Juhola M
Investigating local spatially-enhanced structural and textural descriptors for classification of iPSC colony images.
Conf Proc IEEE Eng Med Biol Soc ;2014

Kankuri E, Harjula A, Pätilä T, Penttinen K, Aalto-Setälä K
[Beating heart cells--targeted diagnostics, individual optimization of therapy and tailored cell therapies].
Duodecim ;130(19)2001-8, 2014

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
Stem Cell Reports ;3(2)269-81, 2014

Ahola A, Kiviaho AL, Larsson K, Honkanen M, Aalto-Setälä K, Hyttinen J
Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation.
Biomed Eng Online ;2014

Vuorenpää H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T
Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes.
In Vitro Cell Dev Biol Anim ;50(4)275-86, 2014

Juhola M, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Iltanen K, Laurikkala J, Hyyrö H, Avalos-Salguero J, Siirtola H, Penttinen K, Aalto-Setälä K
On computation of calcium cycling anomalies in cardiomyocytes data.
Conf Proc IEEE Eng Med Biol Soc ;2014

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkelä E, Hyttinen J, Aalto-Setälä K
Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation.
Int J Biomed Sci ;8(2)109-20, 2012

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.
Dis Model Mech ;5(2)220-30, 2012

Ojala M, Rajala K, Pekkanen-Mattila M, Miettinen M, Huhtala H, Aalto-Setälä K
Culture conditions affect cardiac differentiation potential of human pluripotent stem cells.
PLoS One ;7(10)e48659, 2012

Pekkanen-Mattila M, Ojala M, Kerkelä E, Rajala K, Skottman H, Aalto-Setälä K
The effect of human and mouse fibroblast feeder cells on cardiac differentiation of human pluripotent stem cells.
Stem Cells Int ;2012

Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, Lahtinen AM, Toivonen L, Kontula K, Swan H, Laine M, Silvennoinen O, Aalto-Setälä K
Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.
PLoS One ;7(9)e44660, 2012

Kujala VJ, Jimenez ZC, Väisänen J, Tanskanen JM, Kerkelä E, Hyttinen J, Aalto-Setälä K
Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays.
Comput Methods Programs Biomed ;104(2)199-205, 2011

Rajala K, Pekkanen-Mattila M, Aalto-Setälä K
Cardiac differentiation of pluripotent stem cells.
Stem Cells Int ;2011

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K, Kerkelä E
Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies.
Histochem Cell Biol ;133(5)595-606, 2010

Heliö T, Aalto-Setälä K
[Genetic testing in cardiologic diagnostics].
Duodecim ;126(14)1685-92, 2010

Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H
A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.
PLoS One ;5(4)e10246, 2010

Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, Aalto-Setälä K
Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype.
Exp Biol Med (Maywood) ;235(4)522-30, 2010

Aalto-Setälä K, Conklin BR, Lo B
Obtaining consent for future research with induced pluripotent cells: opportunities and challenges.
PLoS Biol 2009 ;7(2)e42

Pekkanen-Mattila M, Kerkelä E, Tanskanen JM, Pietilä M, Pelto-Huikko M, Hyttinen J, Skottman H, Suuronen R, Aalto-Setälä K
Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions--a comparison of multiple cell lines.
Ann Med 2009 ;41(5)360-70

Laitinen-Forsblom PJ, Mäkynen P, Mäkynen H, Yli-Mäyry S, Virtanen V, Kontula K, Aalto-Setälä K
SCN5A mutation associated with cardiac conduction defect and atrial arrhythmias.
J Cardiovasc Electrophysiol 2006 ;17(5)480-5

Aalto-Setälä K, Karhunen PJ, Mikkelsson J, Niemelä K
The effect of glycoprotein IIIa PIA 1/A2 polymorphism on the PFA-100 response to GP IIb IIa receptor inhibitors-the importance of anticoagulants used.
J Thromb Thrombolysis 2005 ;20(1)57-63

Islam MS, Raitakari OT, Juonala M, Kähönen M, Hutri-Kähönen N, Collings A, Aalto-Setälä K, Kontula K, Marniemi J, Viikari JS, Lehtimäki T
Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis 2005 ;180(1)79-86

Erkkilä L, Laitinen K, Haasio K, Tiirola T, Jauhiainen M, Lehr HA, Aalto-Setälä K, Saikku P, Leinonen M
Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Atherosclerosis 2004 ;177(2)321-8

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