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tampereen yliopisto: lääketieteen ja biotieteiden tiedekunta: tutkimus:
Lääketieteen ja biotieteiden tiedekuntaTampereen yliopistoLääketieteen ja biotieteiden tiedekunta
Andressoo - Solu- ja kudosteknologia

Using the 3’UTR to control gene function and develop targeted therapies



Our laboratory’s long-term goal is to understand gene regulation and develop novel therapeutic approaches by fine-tuning the expression of a gene selectively in cells in which the gene is normally expressed. This innovative approach is complementary to—and in some respects, superior to—current gene deletion and gene over-expression methods.

A gene’s 3’UTR regulates its expression at the post-transcriptional level. Therefore, we explore new methods for manipulating the 3’UTR of target genes. This approach enables us to control endogenous gene expression specifically in cells that naturally express the gene of interest.

In our laboratory, we use state-of-the-art cellular and molecular biology tools to identify molecules that regulate gene expression by interacting with the target gene’s 3’UTR, including microRNAs (miRNAs) and RNA-binding proteins.

To understand the functional role of a gene’s 3’UTR, we generate and analyze mouse models in which the 3’UTR has been targeted, providing constitutive or conditional control over the endogenous gene’s expression.

Our current research focuses on the biology of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). Both BDNF and GDNF modulate the growth and function of a variety of cell types throughout the body, including the central nervous system. We hypothesize that the ability to conditionally upregulate the endogenous expression of BDNF and/or GDNF in mouse models will help establish novel methods for treating a wide range of neurodegenerative disease, including Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. We also use these powerful models to discover new functions for GDNF and BDNF in peripheral tissues, including the urogenital tract and the enteric nervous system.

 
BioMediTech
Lääkärinkatu 1
33520 Tampere, Finland
Ylläpito: webmaster@biomeditech.fi
Muutettu: 30.1.2017 10.16 Muokkaa

Tampereen yliopisto

Tampereen yliopisto
03 355 111
kirjaamo@uta.fi


KARVI-auditoitu HR Excellence in Research

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