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university of tampere: faculty of medicine and life sciences: research: howy jacobs - mitochondrial genetics - mitochondrial biology:
Lääketieteen ja biotieteiden tiedekunta FinMIT Centre of Exellence in research on  mitochondrial disease and ageing University of Tampere Institute of Biomedical Technology - IBT
Howy Jacobs - Mitochondrial Genetics - Mitochondrial Biology

Latest publications

Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Cell Metab ;28(5)764-775.e5, 2018
PMID

Saari S, Garcia GS, Bremer K, Chioda MM, Andjelković A, Debes PV, Nikinmaa M, Szibor M, Dufour E, Rustin P, Oliveira MT, Jacobs HT
Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls.
Biochim Biophys Acta Mol Basis Dis ;2018
PMID

Toompuu M, Tuomela T, Laine P, Paulin L, Dufour E, Jacobs HT
Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells.
Nucleic Acids Res ;46(10)5209-5226, 2018
PMID

Ciesielski GL, Nadalutti CA, Oliveira MT, Jacobs HT, Griffith JD, Kaguni LS
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase.
Nucleic Acids Res ;46(6)3034-3046, 2018
PMID

Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J
Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.
EMBO Mol Med ;2018
PMID

Andjelković A, Mordas A, Bruinsma L, Ketola A, Cannino G, Giordano L, Dhandapani PK, Szibor M, Dufour E, Jacobs HT
Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration.
Mol Cell Biol ;2018
PMID

Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M
Alternative Oxidase Attenuates Cigarette Smoke-Induced Lung Dysfunction and Tissue Damage.
Am J Respir Cell Mol Biol ;2018
PMID

Rodrigues APC, Camargo AF, Andjelković A, Jacobs HT, Oliveira MT
Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.
Sci Rep ;8(1)10882, 2018
PMID

Camargo AF, Chioda MM, Rodrigues APC, Garcia GS, McKinney EA, Jacobs HT, Oliveira MT
Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease.
Cell Biol Int ;42(6)664-669, 2018
PMID

Chrétien D, Bénit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs HT, Rustin P, Rak M
Mitochondria are physiologically maintained at close to 50 °C.
PLoS Biol ;16(1)e2003992, 2018
PMID

Gerards M, Cannino G, de Cózar JMG, Jacobs HT
Intracellular vesicle trafficking plays an essential role in mitochondrial quality control.
Mol Biol Cell ;2018
PMID

Saari S, Andjelković A, Garcia GS, Jacobs HT, Oliveira MT
Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster.
BMC Dev Biol ;17(1)9, 2017
PMID

Salminen TS, Oliveira MT, Cannino G, Lillsunde P, Jacobs HT, Kaguni LS
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.
Mitochondrion ;2017
PMID

 
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