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university of tampere: faculty of medicine and life sciences: research: anne kallioniemi - cancer genomics:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Anne Kallioniemi - Cancer Genomics

Previous publications

Kiiski JI, Tervasmäki A, Pelttari LM, Khan S, Mantere T, Pylkäs K, Mannermaa A, Tengström M, Kvist A, Borg Å, Kosma VM, Kallioniemi A, Schleutker J, Bützow R, Blomqvist C, Aittomäki K, Winqvist R, Nevanlinna H
FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population.
Breast Cancer Res Treat ;166(1)217-226, 2017
PMID

Lehtinen L, Vainio P, Wikman H, Huhtala H, Mueller V, Kallioniemi A, Pantel K, Kronqvist P, Kallioniemi O, Carpèn O, Iljin K
PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells.
J Pathol Clin Res ;3(2)123-138, 2017
PMID

Kuittinen T, Rovio P, Staff S, Luukkaala T, Kallioniemi A, Grénman S, Laurila M, Mäenpää J
In Vitro.
Anticancer Res ;37(12)6575-6581, 2017
PMID

Määttä KM, Nurminen R, Kankuri-Tammilehto M, Kallioniemi A, Laasanen SL, Schleutker J
Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families.
BMC Cancer ;17(1)496, 2017
PMID

Mantere T, Tervasmäki A, Nurmi A, Rapakko K, Kauppila S, Tang J, Schleutker J, Kallioniemi A, Hartikainen JM, Mannermaa A, Nieminen P, Hanhisalo R, Lehto S, Suvanto M, Grip M, Jukkola-Vuorinen A, Tengström M, Auvinen P, Kvist A, Borg Å, Blomqvist C, Aittomäki K, Greenberg RA, Winqvist R, Nevanlinna H, Pylkäs K
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.
Sci Rep ;7(1)681, 2017
PMID

Vuorinen EM, Rajala NK, Rauhala HE, Nurminen AT, Hytönen VP, Kallioniemi A
Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth.
Biochim Biophys Acta ;1863(1)211-219, 2017
PMID

Kiiski JI, Fagerholm R, Tervasmäki A, Pelttari LM, Khan S, Jamshidi M, Mantere T, Pylkäs K, Bartek J, Bartkova J, Mannermaa A, Tengström M, Kosma VM, Winqvist R, Kallioniemi A, Aittomäki K, Blomqvist C, Nevanlinna H
FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome.
Int J Cancer ;139(12)2760-2770, 2016
PMID

Alarmo EL, Havunen R, Häyrynen S, Penkki S, Ketolainen J, Nykter M, Kallioniemi A
Bone morphogenetic protein 4 regulates microRNA expression in breast cancer cell lines in diverse fashion.
Genes Chromosomes Cancer ;55(3)227-36, 2016
PMID

Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H
Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci ;56(11)6265-74, 2015
PMID

Heikkinen T, Khan S, Huovari E, Vilske S, Schleutker J, Kallioniemi A, Blomqvist C, Aittomäki K, Nevanlinna H
Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.
Breast Cancer Res Treat ;144(2)437-41, 2014
PMID

Kiiski JI, Pelttari LM, Khan S, Freysteinsdottir ES, Reynisdottir I, Hart SN, Shimelis H, Vilske S, Kallioniemi A, Schleutker J, Leminen A, Bützow R, Blomqvist C, Barkardottir RB, Couch FJ, Aittomäki K, Nevanlinna H
Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.
Proc Natl Acad Sci U S A ;111(42)15172-7, 2014
PMID

Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD, Tischkowitz M
Breast-cancer risk in families with mutations in PALB2.
N Engl J Med ;371(6)497-506, 2014
PMID

Wikman H, Westphal L, Schmid F, Pollari S, Kropidlowski J, Sielaff-Frimpong B, Glatzel M, Matschke J, Westphal M, Iljin K, Huhtala H, Terracciano L, Kallioniemi A, Sauter G, Müller V, Witzel I, Lamszus K, Kemming D, Pantel K
Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients.
Oncotarget ;5(10)3076-87, 2014
PMID

Laurila E, Vuorinen E, Savinainen K, Rauhala H, Kallioniemi A
KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro.
Exp Cell Res ;322(1)159-67, 2014
PMID

Laurila EM, Kallioniemi A
The diverse role of miR-31 in regulating cancer associated phenotypes.
Genes Chromosomes Cancer ;52(12)1103-13, 2013
PMID

Laurila R, Parkkila S, Isola J, Kallioniemi A, Alarmo EL
The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues.
Int J Clin Exp Pathol ;6(7)1400-8, 2013
PMID

Laitinen VH, Wahlfors T, Saaristo L, Rantapero T, Pelttari LM, Kilpivaara O, Laasanen SL, Kallioniemi A, Nevanlinna H, Aaltonen L, Vessella RL, Auvinen A, Visakorpi T, Tammela TL, Schleutker J
HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.
Cancer Epidemiol Biomarkers Prev ;22(3)452-60, 2013
PMID

Ampuja M, Jokimäki R, Juuti-Uusitalo K, Rodriguez-Martinez A, Alarmo EL, Kallioniemi A
BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment.
BMC Cancer ;2013
PMID

Rauhala HE, Teppo S, Niemelä S, Kallioniemi A
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration.
Anticancer Res ;33(1)45-52, 2013
PMID

Alarmo EL, Huhtala H, Korhonen T, Pylkkänen L, Holli K, Kuukasjärvi T, Parkkila S, Kallioniemi A
Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development.
Mod Pathol ;26(1)10-21, 2013
PMID

Kallioniemi A
Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior.
Cancer Genet ;205(6)267-77, 2012
PMID

Laurila EM, Sandström S, Rantanen LM, Autio R, Kallioniemi A
Both inhibition and enhanced expression of miR-31 lead to reduced migration and invasion of pancreatic cancer cells.
Genes Chromosomes Cancer ;51(6)557-68, 2012
PMID

Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.
Sci Transl Med ;4(122)122ra23, 2012
PMID

Jin K, Kong X, Shah T, Penet MF, Wildes F, Sgroi DC, Ma XJ, Huang Y, Kallioniemi A, Landberg G, Bieche I, Wu X, Lobie PE, Davidson NE, Bhujwalla ZM, Zhu T, Sukumar S
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
Proc Natl Acad Sci U S A ;109(8)2736-41, 2012
PMID

Pylkäs K, Vuorela M, Otsukka M, Kallioniemi A, Jukkola-Vuorinen A, Winqvist R
Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network.
PLoS Genet ;8(6)e1002734, 2012
PMID

Pelttari LM, Kiiski J, Nurminen R, Kallioniemi A, Schleutker J, Gylfe A, Aaltonen LA, Leminen A, Heikkilä P, Blomqvist C, Bützow R, Aittomäki K, Nevanlinna H
A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer.
J Med Genet ;49(7)429-32, 2012
PMID

Virtanen S, Alarmo EL, Sandström S, Ampuja M, Kallioniemi A
Bone morphogenetic protein -4 and -5 in pancreatic cancer--novel bidirectional players.
Exp Cell Res ;317(15)2136-46, 2011
PMID

Pelttari LM, Heikkinen T, Thompson D, Kallioniemi A, Schleutker J, Holli K, Blomqvist C, Aittomäki K, Bützow R, Nevanlinna H
RAD51C is a susceptibility gene for ovarian cancer.
Hum Mol Genet ;20(16)3278-88, 2011
PMID

Kallio H, Tolvanen M, Jänis J, Pan PW, Laurila E, Kallioniemi A, Kilpinen S, Tuominen VJ, Isola J, Valjakka J, Pastorekova S, Pastorek J, Parkkila S
Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.
PLoS One ;6(11)e27152, 2011
PMID

Kuuselo R, Savinainen K, Sandström S, Autio R, Kallioniemi A
MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer.
Int J Cancer ;129(11)2553-65, 2011
PMID

Rodriguez-Martinez A, Alarmo EL, Saarinen L, Ketolainen J, Nousiainen K, Hautaniemi S, Kallioniemi A
Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes.
BMC Med Genomics ;2011
PMID

Ketolainen JM, Alarmo EL, Tuominen VJ, Kallioniemi A
Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4.
Breast Cancer Res Treat ;124(2)377-86, 2010
PMID

Kuuselo R, Simon R, Karhu R, Tennstedt P, Marx AH, Izbicki JR, Yekebas E, Sauter G, Kallioniemi A
19q13 amplification is associated with high grade and stage in pancreatic cancer.
Genes Chromosomes Cancer ;49(6)569-75, 2010
PMID

Wolf M, Korja M, Karhu R, Edgren H, Kilpinen S, Ojala K, Mousses S, Kallioniemi A, Haapasalo H
Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication.
BMC Cancer ;2010
PMID

Alarmo EL, Kallioniemi A
Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?
Endocr Relat Cancer ;17(2)R123-39, 2010
PMID

Kallioniemi A
DNA copy number analysis on tissue microarrays.
Methods Mol Biol ;2010
PMID

Laurila E, Savinainen K, Kuuselo R, Karhu R, Kallioniemi A
Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.
Genes Chromosomes Cancer ;48(4)330-9, 2009
PMID

Alarmo EL, Pärssinen J, Ketolainen JM, Savinainen K, Karhu R, Kallioniemi A
BMP7 influences proliferation, migration, and invasion of breast cancer cells.
Cancer Lett ;275(1)35-43, 2009
PMID

Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi S, Monni O
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.
BMC Genomics ;2008
PMID

Fagerholm R, Hofstetter B, Tommiska J, Aaltonen K, Vrtel R, Syrjäkoski K, Kallioniemi A, Kilpivaara O, Mannermaa A, Kosma VM, Uusitupa M, Eskelinen M, Kataja V, Aittomäki K, von Smitten K, Heikkilä P, Lukas J, Holli K, Bartkova J, Blomqvist C, Bartek J, Nevanlinna H
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
Nat Genet ;40(7)844-53, 2008
PMID

Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis.
J Transl Med ;2008
PMID

Kallioniemi A
CGH microarrays and cancer.
Curr Opin Biotechnol ;19(1)36-40, 2008
PMID

Pärssinen J, Alarmo EL, Khan S, Karhu R, Vihinen M, Kallioniemi A
Identification of differentially expressed genes after PPM1D silencing in breast cancer.
Cancer Lett ;259(1)61-70, 2008
PMID

Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja V, Kosma VM, Xia B, Livingston DM, Winqvist R, Hopper JL
Penetrance analysis of the PALB2 c.1592delT founder mutation.
Clin Cancer Res ;14(14)4667-71, 2008
PMID

Pärssinen J, Alarmo EL, Karhu R, Kallioniemi A
PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.
Cancer Genet Cytogenet ;182(1)33-9, 2008
PMID

Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R
A recurrent mutation in PALB2 in Finnish cancer families.
Nature ;446(7133)316-9, 2007
PMID

Syrjäkoski K, Jäntti J, Kallioniemi A, Karhu R
Mutations in the BRCA2 interacting DSS1 are not a risk factor for male breast cancer.
Int J Cancer ;120(2)444-6, 2007
PMID

Alarmo EL, Kuukasjärvi T, Karhu R, Kallioniemi A
A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7.
Breast Cancer Res Treat ;103(2)239-46, 2007
PMID

Kuuselo R, Savinainen K, Azorsa DO, Basu GD, Karhu R, Tuzmen S, Mousses S, Kallioniemi A
Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification.
Cancer Res ;67(5)1943-9, 2007
PMID

Karhu R, Mahlamäki E, Kallioniemi A
Pancreatic adenocarcinoma -- genetic portrait from chromosomes to microarrays.
Genes Chromosomes Cancer ;45(8)721-30, 2006
PMID

Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjärvi T, Kallioniemi A
Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer.
Genes Chromosomes Cancer ;45(4)411-9, 2006
PMID

Rauta J, Alarmo EL, Kauraniemi P, Karhu R, Kuukasjärvi T, Kallioniemi A
The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours.
Breast Cancer Res Treat ;95(3)257-63, 2006
PMID

Karhu R, Laurila E, Kallioniemi A, Syrjäkoski K
Large genomic BRCA2 rearrangements and male breast cancer.
Cancer Detect Prev ;30(6)530-4, 2006
PMID

Honrado E, Osorio A, Palacios J, Milne RL, Sánchez L, Díez O, Cazorla A, Syrjakoski K, Huntsman D, Heikkilä P, Lerma E, Kallioniemi A, Rivas C, Foulkes WD, Nevanlinna H, Benítez J
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
J Clin Oncol ;23(30)7503-11, 2005
PMID

Laurila E, Syrjäkoski K, Holli K, Kallioniemi A, Karhu R
Search for large genomic alterations of the BRCA1 gene in a Finnish population.
Cancer Genet Cytogenet ;163(1)57-61, 2005
PMID

Wikman H, Nymark P, Väyrynen A, Jarmalaite S, Kallioniemi A, Salmenkivi K, Vainio-Siukola K, Husgafvel-Pursiainen K, Knuutila S, Wolf M, Anttila S
CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer.
Genes Chromosomes Cancer ;42(2)193-9, 2005
PMID

Bärlund M, Kuukasjärvi T, Syrjäkoski K, Auvinen A, Kallioniemi A
Frequent amplification and overexpression of CCND1 in male breast cancer.
Int J Cancer ;111(6)968-71, 2004
PMID

Kauraniemi P, Hautaniemi S, Autio R, Astola J, Monni O, Elkahloun A, Kallioniemi A
Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines.
Oncogene ;23(4)1010-3, 2004
PMID

Skotheim RI, Kallioniemi A, Bjerkhagen B, Mertens F, Brekke HR, Monni O, Mousses S, Mandahl N, Soeter G, Nesland JM, Smeland S, Kallioniemi OP, Lothe RA
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome.
J Clin Oncol ;21(24)4586-91, 2003
PMID

Kauraniemi P, Kuukasjärvi T, Sauter G, Kallioniemi A
Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer.
Am J Pathol ;163(5)1979-84, 2003
PMID

Autio R, Hautaniemi S, Kauraniemi P, Yli-Harja O, Astola J, Wolf M, Kallioniemi A
CGH-Plotter: MATLAB toolbox for CGH-data analysis.
Bioinformatics ;19(13)1714-5, 2003
PMID

Kallioniemi A
[Gene expression profile as a crystal ball].
Duodecim ;119(12)1101-2, 2003
PMID

Andersen CL, Monni O, Wagner U, Kononen J, Bärlund M, Bucher C, Haas P, Nocito A, Bissig H, Sauter G, Kallioniemi A
High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays.
Am J Pathol ;161(1)73-9, 2002
PMID

Kallioniemi A
Molecular signatures of breast cancer--predicting the future.
N Engl J Med ;347(25)2067-8, 2002
PMID

Mahlamäki EH, Bärlund M, Tanner M, Gorunova L, Höglund M, Karhu R, Kallioniemi A
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer.
Genes Chromosomes Cancer ;35(4)353-8, 2002
PMID

Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A
Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.
Genes Chromosomes Cancer ;35(4)311-7, 2002
PMID

Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A
New insights into testicular germ cell tumorigenesis from gene expression profiling.
Cancer Res ;62(8)2359-64, 2002
PMID

Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringnér M, Sauter G, Monni O, Elkahloun A, Kallioniemi OP, Kallioniemi A
Impact of DNA amplification on gene expression patterns in breast cancer.
Cancer Res ;62(21)6240-5, 2002
PMID

Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ, Appella E
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Nat Genet ;31(2)210-5, 2002
PMID

Varis A, Wolf M, Monni O, Vakkari ML, Kokkola A, Moskaluk C, Frierson H, Powell SM, Knuutila S, Kallioniemi A, El-Rifai W
Targets of gene amplification and overexpression at 17q in gastric cancer.
Cancer Res ;62(9)2625-9, 2002
PMID

Mousses S, Kallioniemi A, Kauraniemi P, Elkahloun A, Kallioniemi OP
Clinical and functional target validation using tissue and cell microarrays.
Curr Opin Chem Biol ;6(1)97-101, 2002
PMID

 
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