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university of tampere: faculty of medicine and life sciences: research: marko pesu - immunoregulation:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Marko Pesu - Immunoregulation

Previous publications

Vähätupa M, Aittomäki S, Martinez Cordova Z, May U, Prince S, Uusitalo-Järvinen H, Järvinen TA, Pesu M
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
Oncoimmunology ;5(12)e1245266, 2016
PMID

Cordova ZM, Grönholm A, Kytölä V, Taverniti V, Hämäläinen S, Aittomäki S, Niininen W, Junttila I, Ylipää A, Nykter M, Pesu M
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.
Oncotarget ;7(34)54392-54404, 2016
PMID

Paukkeri EL, Korhonen R, Hämäläinen M, Pesu M, Eskelinen A, Moilanen T, Moilanen E
The Inflammatory Phenotype in Failed Metal-On-Metal Hip Arthroplasty Correlates with Blood Metal Concentrations.
PLoS One ;11(5)e0155121, 2016
PMID

Grönholm A, Junttila I, Pesu M
[Innate lymphoid cells - a new group of immune cells].
Duodecim ;132(9)820-7, 2016
PMID

Pesu M
New insights into the host cell necrosis in tuberculosis.
Virulence ;7(1)1-2, 2016
PMID

Ortutay Z, Oksanen A, Aittomäki S, Ortutay C, Pesu M
Proprotein convertase FURIN regulates T cell receptor-induced transactivation.
J Leukoc Biol 2015 ;98(1)73-83
PMID

Turpeinen H, Seppälä I, Lyytikäinen LP, Raitoharju E, Hutri-Kähönen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kähönen M, Lehtimäki T, Pesu M
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Hum Genet 2015 ;134(6)627-36
PMID

Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M
The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Infect Immun 2015 ;83(4)1431-42
PMID

Hömmö T, Pesu M, Moilanen E, Korhonen R
Regulation of Inflammatory Cytokine Production by MKP-5 in Macrophages.
Basic Clin Pharmacol Toxicol 2015 ;117(2)96-104
PMID

Oksanen A, Aittomäki S, Jankovic D, Ortutay Z, Pulkkinen K, Hämäläinen S, Rokka A, Corthals GL, Watford WT, Junttila I, O'Shea JJ, Pesu M
Proprotein Convertase FURIN Constrains Th2 Differentiation and Is Critical for Host Resistance against Toxoplasma gondii.
J Immunol 2014 ;193(11)5470-9
PMID

Hammarén MM, Oksanen KE, Nisula HM, Luukinen BV, Pesu M, Rämet M, Parikka M
Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish.
PLoS Pathog 2014 ;10(6)e1004190
PMID

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G, Oberste MS, Lahesmaa R, Pesu M, Hyöty H
Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity.
J Med Virol 2014 ;86(8)1412-20
PMID

Aittomäki S, Pesu M
Therapeutic targeting of the Jak/STAT pathway.
Basic Clin Pharmacol Toxicol 2014 ;114(1)18-23
PMID

Taskinen B, Zmurko J, Ojanen M, Kukkurainen S, Parthiban M, Määttä JA, Leppiniemi J, Jänis J, Parikka M, Turpeinen H, Rämet M, Pesu M, Johnson MS, Kulomaa MS, Airenne TT, Hytönen VP
Zebavidin - an avidin-like protein from zebrafish.
PLoS One 2013 ;8(10)e77207
PMID

Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusimäki A, Rämet M, Parikka M, Hytönen VP, Nykter M, Pesu M
Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a).
J Biol Chem 2013 ;288(51)36610-23
PMID

Taverniti V, Stuknyte M, Minuzzo M, Arioli S, De Noni I, Scabiosi C, Cordova ZM, Junttila I, Hämäläinen S, Turpeinen H, Mora D, Karp M, Pesu M, Guglielmetti S
S-layer protein mediates the stimulatory effect of Lactobacillus helveticus MIMLh5 on innate immunity.
Appl Environ Microbiol 2013 ;79(4)1221-31
PMID

Laurence A, Pesu M, Silvennoinen O, O'Shea J
JAK Kinases in Health and Disease: An Update.
Open Rheumatol J 2012 ;6232-44
PMID

Parikka M, Hammarén MM, Harjula SK, Halfpenny NJ, Oksanen KE, Lahtinen MJ, Pajula ET, Iivanainen A, Pesu M, Rämet M
Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish.
PLoS Pathog 2012 ;8(9)e1002944
PMID

Teittinen KJ, Grönroos T, Parikka M, Junttila S, Uusimäki A, Laiho A, Korkeamäki H, Kurppa K, Turpeinen H, Pesu M, Gyenesei A, Rämet M, Lohi O
SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos.
J Cell Biochem 2012 ;113(12)3843-52
PMID

Taverniti V, Minuzzo M, Arioli S, Junttila I, Hämäläinen S, Turpeinen H, Mora D, Karp M, Pesu M, Guglielmetti S
In vitro functional and immunomodulatory properties of the Lactobacillus helveticus MIMLh5-Streptococcus salivarius ST3 association that are relevant to the development of a pharyngeal probiotic product.
Appl Environ Microbiol 2012 ;78(12)4209-16
PMID

Pesu M
Mutant JAK3 FERMents ATLL.
Blood 2011 ;118(14)3759-60
PMID

Marttila S, Jylhävä J, Pesu M, Hämäläinen S, Jylhä M, Hervonen A, Hurme M
IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence.
Exp Gerontol 2011 ;46(12)1000-2
PMID

Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikäinen LP, Järvinen O, Creemers JW, Kähönen M, Laaksonen R, Pelto-Huikko M, Lehtimäki T, Pesu M
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Atherosclerosis 2011 ;219(2)799-806
PMID

Pesu M
[T-helper cells--bandleaders of immune response].
Duodecim 2010 ;126(18)2179-87
PMID

Jiang JK, Ghoreschi K, Deflorian F, Chen Z, Perreira M, Pesu M, Smith J, Nguyen DT, Liu EH, Leister W, Costanzi S, O'Shea JJ, Thomas CJ
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
J Med Chem 2008 ;51(24)8012-8
PMID

Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
J Exp Med 2008 ;205(12)2803-12
PMID

Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, Shevach EM
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
J Exp Med 2008 ;205(9)1975-81
PMID

Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Nature 2008 ;455(7210)246-50
PMID

Pesu M, Laurence A, Kishore N, Zwillich SH, Chan G, O'Shea JJ
Therapeutic targeting of Janus kinases.
Immunol Rev 2008 ;223132-42
PMID

Pesu M, Muul L, Kanno Y, O'Shea JJ
Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.
Blood 2006 ;108(3)983-5
PMID

Pesu M, O'Shea J, Hennighausen L, Silvennoinen O
Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders.
Mol Interv 2005 ;5(4)211-5
PMID

O'Shea JJ, Park H, Pesu M, Borie D, Changelian P
New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.
Curr Opin Rheumatol 2005 ;17(3)305-11
PMID

Pesu M, Candotti F, Husa M, Hofmann SR, Notarangelo LD, O'Shea JJ
Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.
Immunol Rev 2005 ;203127-42
PMID

Yamaoka K, Saharinen P, Pesu M, Holt VE, Silvennoinen O, O'Shea JJ
The Janus kinases (Jaks).
Genome Biol 2004 ;5(12)253
PMID

O'Shea JJ, Pesu M, Borie DC, Changelian PS
A new modality for immunosuppression: targeting the JAK/STAT pathway.
Nat Rev Drug Discov 2004 ;3(7)555-64
PMID

Pesu M, Aittomäki S, Välineva T, Silvennoinen O
PU.1 is required for transcriptional activation of the Stat6 response element in the Igepsilon promoter.
Eur J Immunol 2003 ;33(6)1727-35
PMID

Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O
Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.
EMBO J 2002 ;21(18)4950-8
PMID

Pesu M, Aittomäki S, Takaluoma K, Lagerstedt A, Silvennoinen O
p38 Mitogen-activated protein kinase regulates interleukin-4-induced gene expression by stimulating STAT6-mediated transcription.
J Biol Chem 2002 ;277(41)38254-61
PMID

Aittomäki S, Pesu M, Groner B, Jänne OA, Palvimo JJ, Silvennoinen O
Cooperation among Stat1, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fc gamma receptor I in monocytes.
J Immunol 2000 ;164(11)5689-97
PMID

Pesu M, Takaluoma K, Aittomäki S, Lagerstedt A, Saksela K, Kovanen PE, Silvennoinen O
Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.
Blood 2000 ;95(2)494-502
PMID

 
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