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university of tampere: faculty of medicine and life sciences: research: heli skottman - eye group:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Heli Skottman - Eye Group

Previous publications

Abu Khamidakh AE, Dos Santos FC, Skottman H, Juuti-Uusitalo K, Hyttinen J
Semi-automatic Method for Ca(2+) Imaging Data Analysis of Maturing Human Embryonic Stem Cells-Derived Retinal Pigment Epithelium.
Ann Biomed Eng ;44(11)3408-3420, 2016
PMID

Calejo MT, Ilmarinen T, Jongprasitkul H, Skottman H, Kellomäki M
Honeycomb porous films as permeable scaffold materials for human embryonic stem cell-derived retinal pigment epithelium.
J Biomed Mater Res A ;104(7)1646-56, 2016
PMID

Mikhailova A, Ilmarinen T, Ratnayake A, Petrovski G, Uusitalo H, Skottman H, Rafat M
Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction.
Exp Eye Res ;2016
PMID

Nanni L, Paci M, dos Santos FL, Skottman H, Juuti-Uusitalo K, Hyttinen J
Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium.
PLoS One ;11(2)e0149399, 2016
PMID

Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H
Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium.
PLoS One 2015 ;10(11)e0143669
PMID

Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H
Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci 2015 ;56(11)6265-74
PMID

Mikhailova A, Jylhä A, Rieck J, Nättinen J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H
Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells.
Sci Rep 2015 ;514684
PMID

Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS
Human iPSC derived disease model of MERTK-associated retinitis pigmentosa.
Sci Rep 2015 ;512910
PMID

Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S
Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells.
PLoS One 2015 ;10(6)e0128434
PMID

Polinati PP, Ilmarinen T, Trokovic R, Hyotylainen T, Otonkoski T, Suomalainen A, Skottman H, Tyni T
Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency.
Invest Ophthalmol Vis Sci 2015 ;56(5)3371-82
PMID

Sorkio A, Porter PJ, Juuti-Uusitalo K, Meenan BJ, Skottman H, Burke GA
Surface Modified Biodegradable Electrospun Membranes as a Carrier for Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Tissue Eng Part A 2015 ;21(17-18)2301-14
PMID

Sorkio AE, Vuorimaa-Laukkanen EP, Hakola HM, Liang H, Ujula TA, Valle-Delgado JJ, Österberg M, Yliperttula ML, Skottman H
Biomimetic collagen I and IV double layer Langmuir-Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells.
Biomaterials 2015 ;51257-69
PMID

Käpylä E, Sorkio A, Teymouri S, Lahtonen K, Vuori L, Valden M, Skottman H, Kellomäki M, Juuti-Uusitalo K
Ormocomp-modified glass increases collagen binding and promotes the adherence and maturation of human embryonic stem cell-derived retinal pigment epithelial cells.
Langmuir 2014 ;30(48)14555-65
PMID

Polinati P, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni TA
Patient specific induced pluripotent stem cells derived RPE cells: understanding the pathogenesis of retinopathy in LCHAD deficiency.
Invest Ophthalmol Vis Sci 2014 ;
PMID

Mikhailova A, Ilmarinen T, Uusitalo H, Skottman H
Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells.
Stem Cell Reports 2014 ;2(2)219-31
PMID

Sorkio A, Hongisto H, Kaarniranta K, Uusitalo H, Juuti-Uusitalo K, Skottman H
Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating.
Tissue Eng Part A 2014 ;20(3-4)622-34
PMID

Ylä-Outinen L, Joki T, Varjola M, Skottman H, Narkilahti S
Three-dimensional growth matrix for human embryonic stem cell-derived neuronal cells.
J Tissue Eng Regen Med 2014 ;8(3)186-94
PMID

Ilmarinen T, Laine J, Juuti-Uusitalo K, Numminen J, Seppänen-Suuronen R, Uusitalo H, Skottman H
Towards a defined, serum- and feeder-free culture of stratified human oral mucosal epithelium for ocular surface reconstruction.
Acta Ophthalmol 2012 ;
PMID

Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H
Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes.
Biomaterials 2012 ;33(32)8047-54
PMID

Ylä-Outinen L, Joki T, Varjola M, Skottman H, Narkilahti S
Three-dimensional growth matrix for human embryonic stem cell-derived neuronal cells.
J Tissue Eng Regen Med 2012 ;
PMID

Pekkanen-Mattila M, Ojala M, Kerkelä E, Rajala K, Skottman H, Aalto-Setälä K
The effect of human and mouse fibroblast feeder cells on cardiac differentiation of human pluripotent stem cells.
Stem Cells Int 2012 ;2012875059
PMID

Juuti-Uusitalo K, Vaajasaari H, Ryhänen T, Narkilahti S, Suuronen R, Mannermaa E, Kaarniranta K, Skottman H
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.
PLoS One 2012 ;7(1)e30089
PMID

Onnela N, Savolainen V, Juuti-Uusitalo K, Vaajasaari H, Skottman H, Hyttinen J
Electric impedance of human embryonic stem cell-derived retinal pigment epithelium.
Med Biol Eng Comput 2012 ;50(2)107-16
PMID

Hongisto H, Vuoristo S, Mikhailova A, Suuronen R, Virtanen I, Otonkoski T, Skottman H
Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture.
Stem Cell Res 2012 ;8(1)97-108
PMID

, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
Nat Biotechnol 2011 ;29(12)1132-44
PMID

Sundberg M, Hyysalo A, Skottman H, Shin S, Vemuri M, Suuronen R, Narkilahti S
A xeno-free culturing protocol for pluripotent stem cell-derived oligodendrocyte precursor cell production.
Regen Med 2011 ;6(4)449-60
PMID

Vaajasaari H, Ilmarinen T, Juuti-Uusitalo K, Rajala K, Onnela N, Narkilahti S, Suuronen R, Hyttinen J, Uusitalo H, Skottman H
Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells.
Mol Vis 2011 ;17558-75
PMID

Ylä-Outinen L, Heikkilä J, Skottman H, Suuronen R, Aänismaa R, Narkilahti S
Human cell-based micro electrode array platform for studying neurotoxicity.
Front Neuroeng 2010 ;3
PMID

Lappalainen RS, Salomäki M, Ylä-Outinen L, Heikkilä TJ, Hyttinen JA, Pihlajamäki H, Suuronen R, Skottman H, Narkilahti S
Similarly derived and cultured hESC lines show variation in their developmental potential towards neuronal cells in long-term culture.
Regen Med 2010 ;5(5)749-62
PMID

Sundberg M, Skottman H, Suuronen R, Narkilahti S
Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium.
Stem Cell Res 2010 ;5(2)91-103
PMID

Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H
A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.
PLoS One 2010 ;5(4)e10246
PMID

Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, Aalto-Setälä K
Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype.
Exp Biol Med (Maywood) 2010 ;235(4)522-30
PMID

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K, Kerkelä E
Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies.
Histochem Cell Biol 2010 ;133(5)595-606
PMID

Skottman H
Derivation and characterization of three new human embryonic stem cell lines in Finland.
In Vitro Cell Dev Biol Anim 2010 ;46(3-4)206-9
PMID

Auer S, Lappalainen RS, Skottman H, Suuronen R, Narkilahti S, Vikholm-Lundin I
An antibody surface for selective neuronal cell attachment.
J Neurosci Methods 2010 ;186(1)72-6
PMID

Zhang P, Zucchelli M, Bruce S, Hambiliki F, Stavreus-Evers A, Levkov L, Skottman H, Kerkelä E, Kere J, Hovatta O
Transcriptome profiling of human pre-implantation development.
PLoS One 2009 ;4(11)e7844
PMID

Heikkilä TJ, Ylä-Outinen L, Tanskanen JM, Lappalainen RS, Skottman H, Suuronen R, Mikkonen JE, Hyttinen JA, Narkilahti S
Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro.
Exp Neurol 2009 ;218(1)109-16
PMID

Sundberg M, Jansson L, Ketolainen J, Pihlajamäki H, Suuronen R, Skottman H, Inzunza J, Hovatta O, Narkilahti S
CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells.
Stem Cell Res 2009 ;2(2)113-24
PMID

Pekkanen-Mattila M, Kerkelä E, Tanskanen JM, Pietilä M, Pelto-Huikko M, Hyttinen J, Skottman H, Suuronen R, Aalto-Setälä K
Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions--a comparison of multiple cell lines.
Ann Med 2009 ;41(5)360-70
PMID

Hakala H, Rajala K, Ojala M, Panula S, Areva S, Kellomäki M, Suuronen R, Skottman H
Comparison of biomaterials and extracellular matrices as a culture platform for multiple, independently derived human embryonic stem cell lines.
Tissue Eng Part A 2009 ;15(7)1775-85
PMID

Unger C, Skottman H, Blomberg P, Dilber MS, Hovatta O
Good manufacturing practice and clinical-grade human embryonic stem cell lines.
Hum Mol Genet 2008 ;17(R1)R48-53
PMID

Skottman H, Narkilahti S, Hovatta O
Challenges and approaches to the culture of pluripotent human embryonic stem cells.
Regen Med 2007 ;2(3)265-73
PMID

Narkilahti S, Rajala K, Pihlajamäki H, Suuronen R, Hovatta O, Skottman H
Monitoring and analysis of dynamic growth of human embryonic stem cells: comparison of automated instrumentation and conventional culturing methods.
Biomed Eng Online 2007 ;611
PMID

Rajala K, Hakala H, Panula S, Aivio S, Pihlajamäki H, Suuronen R, Hovatta O, Skottman H
Testing of nine different xeno-free culture media for human embryonic stem cell cultures.
Hum Reprod 2007 ;22(5)1231-8
PMID

Zhang P, Kerkelä E, Skottman H, Levkov L, Kivinen K, Lahesmaa R, Hovatta O, Kere J
Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells.
Fertil Steril 2007 ;87(3)677-90
PMID

Kerkelä E, Skottman H, Friden B, Bjuresten K, Kere J, Hovatta O
Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome.
Fertil Steril 2007 ;87(3)603-6
PMID

Grinnemo KH, Kumagai-Braesch M, Månsson-Broberg A, Skottman H, Hao X, Siddiqui A, Andersson A, Strömberg AM, Lahesmaa R, Hovatta O, Sylven C, Corbascio M, Dellgren G
Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings.
Reprod Biomed Online 2006 ;13(5)712-24
PMID

Skottman H, Hovatta O
Culture conditions for human embryonic stem cells.
Reproduction 2006 ;132(5)691-8
PMID

Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O
Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells.
Fertil Steril 2006 ;86(4 Suppl)1193-209
PMID

Skottman H, Dilber MS, Hovatta O
The derivation of clinical-grade human embryonic stem cell lines.
FEBS Lett 2006 ;580(12)2875-8
PMID

Skottman H, Strömberg AM, Matilainen E, Inzunza J, Hovatta O, Lahesmaa R
Unique gene expression signature by human embryonic stem cells cultured under serum-free conditions correlates with their enhanced and prolonged growth in an undifferentiated stage.
Stem Cells 2006 ;24(1)151-67
PMID

Elo LL, Lahti L, Skottman H, Kyläniemi M, Lahesmaa R, Aittokallio T
Integrating probe-level expression changes across generations of Affymetrix arrays.
Nucleic Acids Res 2005 ;33(22)e193
PMID

Skottman H, Mikkola M, Lundin K, Olsson C, Strömberg AM, Tuuri T, Otonkoski T, Hovatta O, Lahesmaa R
Gene expression signatures of seven individual human embryonic stem cell lines.
Stem Cells 2005 ;23(9)1343-56
PMID

Inzunza J, Gertow K, Strömberg MA, Matilainen E, Blennow E, Skottman H, Wolbank S, Ahrlund-Richter L, Hovatta O
Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells.
Stem Cells 2005 ;23(4)544-9
PMID

 
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