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university of tampere: faculty of medicine and life sciences: research:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Daniela Ungureanu - Cancer Signaling

About Research Group

Our research focuses on understanding the role of ROR family of pseudokinases in cancer signaling. We aim to characterize the structural and functional properties of ROR1 and ROR2 and define the molecular networks employed by this family of proteins in normal and pathological signaling cascades.

Nearly 10% of known kinases are classified as pseudokinases due to the lack one or more residues required for the phospho-transfer reaction. Recent structural and functional studies have provided important new insights into this class of atypical protein kinases and have shown that some pseudokinases possess catalytic activity that involve unique phosphor-transfer mechanisms. It has also become evident that aberrant regulation of pseudokinases plays a critical role in human diseases. Almost 30% of all pseudokinases are reported to have a role in cancer.

Our special interest is on the molecular mechanisms by which the ROR receptor tyrosine kinases participate in signal transduction events. We are investigating their enzymatic function and molecular structure using biochemical assays for recombinant proteins. In collaboration with clinical researchers, we aim to characterize potential biomarkers for cancer therapies and seek to identify small molecule inhibitors that target ROR functions in human diseases.

We are always looking for talented scientists. If you are interested to join our group for short-term or long-term projects, we encourage you to send in your CV and a letter of motivation.

 
Faculty of Medicine and Life Sciences
Arvo Ylpön katu 34
33520 Tampere, Finland
Maintained by: webmaster@biomeditech.fi
Last update: 5.2.2015 7.18 Muokkaa

University of Tampere
+358 3 355 111
registry@uta.fi


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