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university of tampere: faculty of medicine and life sciences: research: daniela ungureanu - cancer signaling:
Lääketieteen ja biotieteiden tiedekuntaUniversity of TampereLääketieteen ja biotieteiden tiedekunta
Daniela Ungureanu - Cancer Signaling

Previous publications

Karvonen H, Niininen W, Murumägi A, Ungureanu D
Targeting ROR1 identifies new treatment strategies in hematological cancers.
Biochem Soc Trans ;45(2)457-464, 2017

Karvonen H, Chiron D, Niininen W, Ek S, Jerkeman M, Moradi E, Nykter M, Heckman CA, Kallioniemi O, Murumägi A, Ungureanu D
Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma.
Blood Adv ;1(24)2257-2268, 2017

Filipescu D, Bănăţeanu R, Beuran M, Burcoş T, Corneci D, Cristian D, Diculescu M, Dobrotă A, Droc G, Isacoff D, Goşa D, Grinţescu I, Lupu A, Mirea L, Posea C, Stanca O, Ştefan M, Tomescu D, Tudor C, Ungureanu D, Mircescu G
Patient Blood Management Initiative Group.
Rom J Anaesth Intensive Care ;24(2)139-157, 2017

Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
ACS Med Chem Lett ;8(6)618-621, 2017

Tomescu D, Popescu M, Jipa L, Fota R, Ungureanu D, Zamfir R, Orban C, Dima SO, Popescu I
The impact of donor liver graft quality on postoperative outcome in liver transplant recipients. A single centre experience.
Rom J Anaesth Intensive Care ;23(1)19-26, 2016

Tomescu DR, Olimpia Dima S, Ungureanu D, Popescu M, Tulbure D, Popescu I
First report of cytokine removal using CytoSorb® in severe noninfectious inflammatory syndrome after liver transplantation.
Int J Artif Organs ;39(3)136-40, 2016

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
J Biol Chem ;290(45)27261-70, 2015

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Proc Natl Acad Sci U S A ;112(15)4642-7, 2015

Sanz Sanz A, Niranjan Y, Hammarén H, Ungureanu D, Ruijtenbeek R, Touw IP, Silvennoinen O, Hilhorst R
The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.
Biochim Biophys Acta ;1844(10)1835-41, 2014

Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Nat Struct Mol Biol ;21(7)579-84, 2014

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
Biochem J ;458(2)395-405, 2014

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Biochem J ;457(2)323-34, 2014

Grönholm J, Vanhatupa S, Ungureanu D, Väliaho J, Laitinen T, Valjakka J, Silvennoinen O
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.
BMC Biochem ;2012

Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat Struct Mol Biol ;19(8)754-9, 2012

Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.
Nat Struct Mol Biol ;18(9)971-6, 2011

Sanz A, Ungureanu D, Pekkala T, Ruijtenbeek R, Touw IP, Hilhorst R, Silvennoinen O
Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation.
PLoS One ;6(4)e18522, 2011

Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O
Sumoylation of Drosophila transcription factor STAT92E.
J Innate Immun ;2(6)618-24, 2010

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