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tampereen yliopisto: lääketieteen ja biotieteiden tiedekunta: julkaisut:
Lääketieteen ja biotieteiden tiedekuntaTampereen yliopisto BioMediTech

IBT julkaisut 2001

NOTE: This list is not exhaustive because it has been collected by an automatic procedure from PubMed. It may also contain publications not related to IMT or Regea authors (authors having the same name). The same publication may also appear more than once in case several research groups have participated in the writing.
Vihinen M
Bioinformatics in proteomics.
Biomol Eng 2001 ;18(5)241-8
PMID

Aalto Y, El-Rifa W, Vilpo L, Ollila J, Nagy B, Vihinen M, Vilpo J, Knuutila S
Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion.
Leukemia 2001 ;15(11)1721-8
PMID

Notarangelo LD, Mella P, Jones A, de Saint Basile G, Savoldi G, Cranston T, Vihinen M, Schumacher RF
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.
Hum Mutat 2001 ;18(4)255-63
PMID

Hyyro H, Vihinen M, Juhola M
On approximate string matching of unique oligonucleotides.
Stud Health Technol Inform 2001 ;84(Pt 2)960-4
PMID

Riikonen P, Boberg J, Salakoski T, Vihinen M
BioWAP, mobile Internet service for bioinformatics.
Bioinformatics 2001 ;17(9)855-6
PMID

Speletas M, Kanariou M, Kanakoudi-Tsakalidou F, Papadopoulou-Alataki E, Arvanitidis K, Pardali E, Constantopoulos A, Kartalis G, Vihinen M, Sideras P, Ritis K
Analysis of Btk mutations in patients with X-linked agammaglobulinaemia (XLA) and determination of carrier status in normal female relatives: a nationwide study of Btk deficiency in Greece.
Scand J Immunol 2001 ;54(3)321-7
PMID

Siermala M, Juhola M, Vihinen M
On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures.
Comput Biol Med 2001 ;31(5)385-98
PMID

Sobacchi C, Frattini A, Orchard P, Porras O, Tezcan I, Andolina M, Babul-Hirji R, Baric I, Canham N, Chitayat D, Dupuis-Girod S, Ellis I, Etzioni A, Fasth A, Fisher A, Gerritsen B, Gulino V, Horwitz E, Klamroth V, Lanino E, Mirolo M, Musio A, Matthijs G, Nonomaya S, Notarangelo LD, Ochs HD, Superti Furga A, Valiaho J, van Hove JL, Vihinen M, Vujic D, Vezzoni P, Villa A
The mutational spectrum of human malignant autosomal recessive osteopetrosis.
Hum Mol Genet 2001 ;10(17)1767-73
PMID

Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M
The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.
Bioessays 2001 ;23(5)436-46
PMID

Hansson H, Okoh MP, Smith CI, Vihinen M, Hard T
Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.
FEBS Lett 2001 ;489(1)67-70
PMID

Nars M, Vihinen M
Coevolution of the domains of cytoplasmic tyrosine kinases.
Mol Biol Evol 2001 ;18(3)312-21
PMID

Villa A, Sobacchi C, Notarangelo LD, Bozzi F, Abinun M, Abrahamsen TG, Arkwright PD, Baniyash M, Brooks EG, Conley ME, Cortes P, Duse M, Fasth A, Filipovich AM, Infante AJ, Jones A, Mazzolari E, Muller SM, Pasic S, Rechavi G, Sacco MG, Santagata S, Schroeder ML, Seger R, Strina D, Ugazio A, Valiaho J, Vihinen M, Vogler LB, Ochs H, Vezzoni P, Friedrich W, Schwarz K
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations.
Blood 2001 ;97(1)81-8
PMID

Vihinen M, Arredondo-Vega FX, Casanova JL, Etzioni A, Giliani S, Hammarstrom L, Hershfield MS, Heyworth PG, Hsu AP, Lahdesmaki A, Lappalainen I, Notarangelo LD, Puck JM, Reith W, Roos D, Schumacher RF, Schwarz K, Vezzoni P, Villa A, Valiaho J, Smith CI
Primary immunodeficiency mutation databases.
Adv Genet 2001 ;43103-88
PMID

Saarenmaa I, Salminen T, Geiger U, Heikkinen P, Hyvärinen S, Isola J, Kataja V, Kokko ML, Kokko R, Kumpulainen E, Kärkkäinen A, Pakkanen J, Peltonen P, Piironen A, Salo A, Talviala ML, Hakama M
Validity of radiological examinations of patients with breast cancer in different age groups in a population based study.
Breast 2001 ;10(1)78-81
PMID

Paunu N, Syrjäkoski K, Sankila R, Simola KO, Helén P, Niemelä M, Matikainen M, Isola J, Haapasalo H
Analysis of p53 tumor suppressor gene in families with multiple glioma patients.
J Neurooncol 2001 ;55(3)159-65
PMID

Staff S, Isola JJ, Johannsson O, Borg A, Tanner MM
Frequent somatic loss of BRCA1 in breast tumours from BRCA2 germ-line mutation carriers and vice versa.
Br J Cancer 2001 ;85(8)1201-5
PMID

Rummukainen JK, Salminen T, Lundin J, Joensuu H, Isola JJ
Amplification of c-myc oncogene by chromogenic and fluorescence in situ hybridization in archival breast cancer tissue array samples.
Lab Invest 2001 ;81(11)1545-51
PMID

Rummukainen JK, Salminen T, Lundin J, Kytölä S, Joensuu H, Isola JJ
Amplification of c-myc by fluorescence in situ hybridization in a population-based breast cancer tissue array.
Mod Pathol 2001 ;14(10)1030-5
PMID

Di Leo A, Larsimont D, Gancberg D, Jarvinen T, Beauduin M, Vindevoghel A, Michel J, Focan CH, Ries F, Gobert PH, Closon-Dejardin MT, Dolci S, Rouas G, Paesmans M, Lobelle JP, Isola J, Piccart MJ
HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide.
Ann Oncol 2001 ;12(8)1081-9
PMID

Saarenmaa I, Salminen T, Geiger U, Heikkinen P, Hyvärinen S, Isola J, Kataja V, Kokko ML, Kokko R, Kumpulainen E, Kärkkäinen A, Pakkanen J, Peltonen P, Piironen A, Salo A, Talviala ML, Haka M
The effect of age and density of the breast on the sensitivity of breast cancer diagnostic by mammography and ultasonography.
Breast Cancer Res Treat 2001 ;67(2)117-23
PMID

Tanner M, Järvinen P, Isola J
Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer.
Cancer Res 2001 ;61(14)5345-8
PMID

Rummukainen J, Kytölä S, Karhu R, Farnebo F, Larsson C, Isola JJ
Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.
Cancer Genet Cytogenet 2001 ;126(1)1-7
PMID

Isola J, Auvinen A, Poutiainen M, Kakkola L, Järvinen TA, Määttänen L, Stenman UH, Tammela T, Hakama M, Visakorpi T
Predictors of biological aggressiveness of prostate specific antigen screening detected prostate cancer.
J Urol 2001 ;165(5)1569-74
PMID

Launonen V, Vierimaa O, Kiuru M, Isola J, Roth S, Pukkala E, Sistonen P, Herva R, Aaltonen LA
Inherited susceptibility to uterine leiomyomas and renal cell cancer.
Proc Natl Acad Sci U S A 2001 ;98(6)3387-92
PMID

Rennstam K, Baldetorp B, Kytölä S, Tanner M, Isola J
Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer.
Cancer Res 2001 ;61(3)1214-9
PMID

Saarenmaa I, Salminen T, Geiger U, Heikkinen P, Hyvärinen S, Isola J, Kataja V, Kokko ML, Kokko R, Kumpulainen E, Kärkkäinen A, Pakkanen J, Peltonen P, Piironen A, Salo A, Talviala ML, Hakama M
The visibility of cancer on previous mammograms in retrospective review.
Clin Radiol 2001 ;56(1)40-3
PMID

Holli K, Saaristo R, Isola J, Joensuu H, Hakama M
Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study.
Br J Cancer 2001 ;84(2)164-9
PMID

Pan Y, Lui WO, Nupponen N, Larsson C, Isola J, Visakorpi T, Bergerheim US, Kytölä S
5q11, 8p11, and 10q22 are recurrent chromosomal breakpoints in prostate cancer cell lines.
Genes Chromosomes Cancer 2001 ;30(2)187-95
PMID

Karhu R, Ahlstedt-Soini M, Bittner M, Meltzer P, Trent JM, Isola JJ
Chromosome arm-specific multicolor FISH.
Genes Chromosomes Cancer 2001 ;30(1)105-9
PMID

Ramet M, Pearson A, Manfruelli P, Li X, Koziel H, Gobel V, Chung E, Krieger M, Ezekowitz RA
Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria.
Immunity 2001 ;15(6)1027-38
PMID

Haataja R, Marttila R, Uimari P, Lofgren J, Ramet M, Hallman M
Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test.
Hum Genet 2001 ;109(3)351-5
PMID

Floros J, Fan R, Matthews A, DiAngelo S, Luo J, Nielsen H, Dunn M, Gewolb IH, Koppe J, van Sonderen L, Farri-Kostopoulos L, Tzaki M, Ramet M, Merrill J
Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences.
Clin Genet 2001 ;60(3)178-87
PMID

Hallman M, Ramet M, Ezekowitz RA
Toll-like receptors as sensors of pathogens.
Pediatr Res 2001 ;50(3)315-21
PMID

Hallman M, Glumoff V, Ramet M
Surfactant in respiratory distress syndrome and lung injury.
Comp Biochem Physiol A Mol Integr Physiol 2001 ;129(1)287-94
PMID

Ramet M, Lofgren J, Alho OP, Hallman M
Surfactant protein-A gene locus associated with recurrent otitis media.
J Pediatr 2001 ;138(2)266-8
PMID

Hiipakka M, Huotari P, Manninen A, Renkema GH, Saksela K
Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.
Virology 2001 ;286(1)152-9
PMID

Manninen A, Huotari P, Hiipakka M, Renkema GH, Saksela K
Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta.
J Virol 2001 ;75(6)3034-7
PMID

Renkema GH, Manninen A, Saksela K
Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX.
J Virol 2001 ;75(5)2154-60
PMID

Kajander OA, Karhunen PJ, Holt IJ, Jacobs HT
Prominent mitochondrial DNA recombination intermediates in human heart muscle.
EMBO Rep 2001 ;2(11)1007-12
PMID

Rovio AT, Marchington DR, Donat S, Schuppe HC, Abel J, Fritsche E, Elliott DJ, Laippala P, Ahola AL, McNay D, Harrison RF, Hughes B, Barrett T, Bailey DM, Mehmet D, Jequier AM, Hargreave TB, Kao SH, Cummins JM, Barton DE, Cooke HJ, Wei YH, Wichmann L, Poulton J, Jacobs HT
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
Nat Genet 2001 ;29(3)261-2
PMID

Jacobs HT
Making mitochondrial mutants.
Trends Genet 2001 ;17(11)653-60
PMID

Toivonen JM, O'Dell KM, Petit N, Irvine SC, Knight GK, Lehtonen M, Longmuir M, Luoto K, Touraille S, Wang Z, Alziari S, Shah ZH, Jacobs HT
Technical knockout, a Drosophila model of mitochondrial deafness.
Genetics 2001 ;159(1)241-54
PMID

Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, Santoro L, Toscano A, Fabrizi GM, Somer H, Croxen R, Beeson D, Poulton J, Suomalainen A, Jacobs HT, Zeviani M, Larsson C
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Nat Genet 2001 ;28(3)223-31
PMID

Shah ZH, Toompuu M, Hakkinen T, Rovio AT, van Ravenswaay C, De Leenheer EM, Smith RJ, Cremers FP, Cremers CW, Jacobs HT
Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness families.
Hum Mutat 2001 ;17(5)433-4
PMID

Barkardottir RB, Sarantaus L, Arason A, Vehmanen P, Bendahl PO, Kainu T, Syrjakoski K, Krahe R, Huusko P, Pyrhonen S, Holli K, Kallioniemi OP, Egilsson V, Kere J, Nevanlinna H
Haplotype analysis in Icelandic and Finnish BRCA2 999del5 breast cancer families.
Eur J Hum Genet 2001 ;9(10)773-9
PMID

Mousses S, Wagner U, Chen Y, Kim JW, Bubendorf L, Bittner M, Pretlow T, Elkahloun AG, Trepel JB, Kallioniemi OP
Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling.
Oncogene 2001 ;20(46)6718-23
PMID

Torhorst J, Bucher C, Kononen J, Haas P, Zuber M, Kochli OR, Mross F, Dieterich H, Moch H, Mihatsch M, Kallioniemi OP, Sauter G
Tissue microarrays for rapid linking of molecular changes to clinical endpoints.
Am J Pathol 2001 ;159(6)2249-56
PMID

Ikonen T, Matikainen M, Mononen N, Hyytinen ER, Helin HJ, Tommola S, Tammela TL, Pukkala E, Schleutker J, Kallioniemi OP, Koivisto PA
Association of E-cadherin germ-line alterations with prostate cancer.
Clin Cancer Res 2001 ;7(11)3465-71
PMID

Forus A, D'Angelo A, Henriksen J, Merla G, Maelandsmo GM, Florenes VA, Olivieri S, Bjerkehagen B, Meza-Zepeda LA, del Vecchio Blanco F, Muller C, Sanvito F, Kononen J, Nesland JM, Fodstad O, Reymond A, Kallioniemi OP, Arrigoni G, Ballabio A, Myklebost O, Zollo M
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity.
Oncogene 2001 ;20(47)6881-90
PMID

Srivastava M, Bubendorf L, Nolan L, Glasman M, Leighton X, Miller G, Fehrle W, Raffeld M, Eidelman O, Kallioniemi OP, Srivastava S, Pollard HB
ANX7 as a bio-marker in prostate and breast cancer progression.
Dis Markers 2001 ;17(2)115-20
PMID

Nocito A, Kononen J, Kallioniemi OP, Sauter G
Tissue microarrays (TMAs) for high-throughput molecular pathology research.
Int J Cancer 2001 ;94(1)1-5
PMID

Monni O, Hyman E, Mousses S, Barlund M, Kallioniemi A, Kallioniemi OP
From chromosomal alterations to target genes for therapy: integrating cytogenetic and functional genomic views of the breast cancer genome.
Semin Cancer Biol 2001 ;11(5)395-401
PMID

Rokman A, Ikonen T, Mononen N, Autio V, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J
ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.
Cancer Res 2001 ;61(16)6038-41
PMID

Matikaine MP, Pukkala E, Schleutker J, Tammela TL, Koivisto P, Sankila R, Kallioniemi OP
Relatives of prostate cancer patients have an increased risk of prostate and stomach cancers: a population-based, cancer registry study in Finland.
Cancer Causes Control 2001 ;12(3)223-30
PMID

Mononen N, Ikonen T, Syrjakoski K, Matikainen M, Schleutker J, Tammela TL, Koivisto PA, Kallioniemi OP
A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland.
Br J Cancer 2001 ;84(10)1344-7
PMID

Kallioniemi OP
Biochip technologies in cancer research.
Ann Med 2001 ;33(2)142-7
PMID

Srivastava M, Bubendorf L, Srikantan V, Fossom L, Nolan L, Glasman M, Leighton X, Fehrle W, Pittaluga S, Raffeld M, Koivisto P, Willi N, Gasser TC, Kononen J, Sauter G, Kallioniemi OP, Srivastava S, Pollard HB
ANX7, a candidate tumor suppressor gene for prostate cancer.
Proc Natl Acad Sci U S A 2001 ;98(8)4575-80
PMID

Kallioniemi OP, Wagner U, Kononen J, Sauter G
Tissue microarray technology for high-throughput molecular profiling of cancer.
Hum Mol Genet 2001 ;10(7)657-62
PMID

Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP, Wilfond B, Borg A, Trent J, Raffeld M, Yakhini Z, Ben-Dor A, Dougherty E, Kononen J, Bubendorf L, Fehrle W, Pittaluga S, Gruvberger S, Loman N, Johannsson O, Olsson H, Sauter G
Gene-expression profiles in hereditary breast cancer.
N Engl J Med 2001 ;344(8)539-48
PMID

Rokman A, Koivisto PA, Matikainen MP, Kuukasjarvi T, Poutiainen M, Helin HJ, Karhu R, Kallioniemi OP, Schleutker J
Genetic changes in familial prostate cancer by comparative genomic hybridization.
Prostate 2001 ;46(3)233-9
PMID

Moch H, Kononen T, Kallioniemi OP, Sauter G
Tissue microarrays: what will they bring to molecular and anatomic pathology?
Adv Anat Pathol 2001 ;8(1)14-20
PMID

Rapakko K, Allinen M, Syrjakoski K, Vahteristo P, Huusko P, Vahakangas K, Eerola H, Kainu T, Kallioniemi OP, Nevanlinna H, Winqvist R
Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites.
Br J Cancer 2001 ;84(1)116-9
PMID

Krohn K, Florke U, Rao MS, Steingrover K, Aust HJ, Draeger S, Schulz B
Metabolites from fungi 15. New isocoumarins from an endophytic fungus isolated from the Canadian thistle Cirsium arvense.
Nat Prod Lett 2001 ;15(5)353-61
PMID

Krohn K, Rao MS, Raman NV, Khalilullah M
High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.
Phytochem Anal ;12(6)374-6
PMID

Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T
Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease.
Circulation 2001 ;104(22)2673-8
PMID

Salamon A, Hagenauer B, Thalhammer T, Szekeres T, Krohn K, Jayaram HN, Jager W
Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver.
Life Sci 2001 ;69(21)2489-502
PMID

Eszlinger M, Krohn K, Paschke R
Complementary DNA expression array analysis suggests a lower expression of signal transduction proteins and receptors in cold and hot thyroid nodules.
J Clin Endocrinol Metab 2001 ;86(10)4834-42
PMID

Lin Y, Wu X, Feng S, Jiang G, Luo J, Zhou S, Vrijmoed LL, Jones EB, Krohn K, Steingrover K, Zsila F
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast.
J Org Chem 2001 ;66(19)6252-6
PMID

Krohn K, John M, Aust HJ, Draeger S, Schulz B
Biologically active metabolites from fungi 14 3-chloro-4-hydroxy-5-(3,7,11-trimethyldodeca-2,6,10-trienyl)-benzamide, a new antibacterial agent from a soil fungus.
Nat Prod Lett 2001 ;15(1)9-12
PMID

Krohn K, Reske A, Ackermann F, Muller A, Paschke R
Ras mutations are rare in solitary cold and toxic thyroid nodules.
Clin Endocrinol (Oxf) 2001 ;55(2)241-8
PMID

Krohn K, Paschke R
Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.
Thyroid 2001 ;11(8)741-7
PMID

Cihakova D, Trebusak K, Heino M, Fadeyev V, Tiulpakov A, Battelino T, Tar A, Halasz Z, Blumel P, Tawfik S, Krohn K, Lebl J, Peterson P
Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED.
Hum Mutat 2001 ;18(3)225-32
PMID

Heino M, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS, Krohn K
APECED mutations in the autoimmune regulator (AIRE) gene.
Hum Mutat 2001 ;18(3)205-11
PMID

Krohn KA
The physical chemistry of ligand-receptor binding identifies some limitations to the analysis of receptor images.
Nucl Med Biol 2001 ;28(5)477-83
PMID

Wallaschofski H, Orda C, Fuhrer D, Holzapfel HP, Krohn K, Miehle K, Neumann S, Georgi P, Paschke R
Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.
Thyroid 2001 ;11(7)710-1
PMID

Krohn KA
Evaluation of alternative approaches for imaging cellular growth.
Q J Nucl Med 2001 ;45(2)174-8
PMID

Krohn KA, Mankoff DA, Eary JF
Imaging cellular proliferation as a measure of response to therapy.
J Clin Pharmacol 2001 ;Suppl96S-103S
PMID

Krohn K, Paschke R
Clinical review 133: Progress in understanding the etiology of thyroid autonomy.
J Clin Endocrinol Metab 2001 ;86(7)3336-45
PMID

Neumann S, Krohn K, Chey S, Paschke R
Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.
Horm Metab Res 2001 ;33(5)263-9
PMID

Trulzsch B, Krohn K, Wonerow P, Chey S, Holzapfel HP, Ackermann F, Fuhrer D, Paschke R
Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.
J Mol Med 2001 ;78(12)684-91
PMID

Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T
Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.
Free Radic Biol Med 2001 ;31(1)53-61
PMID

Mankoff DA, Link JM, Unadkat J, Eary JF, Krohn KA
More collaboration needed between drug development and imaging communities.
Drug Discov Today 2001 ;6(10)514-515
PMID

Kjerrstrom A, Hinkula J, Engstrom G, Ovod V, Krohn K, Benthin R, Wahren B
Interactions of single and combined human immunodeficiency virus type 1 (HIV-1) DNA vaccines.
Virology 2001 ;284(1)46-61
PMID

Mankoff DA, Peterson LM, Tewson TJ, Link JM, Gralow JR, Graham MM, Krohn KA
[18F]fluoroestradiol radiation dosimetry in human PET studies.
J Nucl Med 2001 ;42(4)679-84
PMID

Aapola U, Lyle R, Krohn K, Antonarakis SE, Peterson P
Isolation and initial characterization of the mouse Dnmt3l gene.
Cytogenet Cell Genet 2001 ;92(1-2)122-6
PMID

Muzi M, Freeman SD, Burrows RC, Wiseman RW, Link JM, Krohn KA, Graham MM, Spence AM
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Nucl Med Biol 2001 ;28(2)107-16
PMID

Eszlinger M, Krohn K, Kratzsch J, Voigt C, Paschke R
Growth factor expression in cold and hot thyroid nodules.
Thyroid 2001 ;11(2)125-35
PMID

Pitkanen J, Vahamurto P, Krohn K, Peterson P
Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain.
J Biol Chem 2001 ;276(22)19597-602
PMID

Tahtinen M, Strengell M, Collings A, Pitkanen J, Kjerrstrom A, Hakkarainen K, Peterson P, Kohleisen B, Wahren B, Ranki A, Ustav M, Krohn K
DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector.
Vaccine 2001 ;19(15-16)2039-47
PMID

Fackler OT, Wolf D, Weber HO, Laffert B, D'Aloja P, Schuler-Thurner B, Geffin R, Saksela K, Geyer M, Peterlin BM, Schuler G, Baur AS
A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.
Curr Biol 2001 ;11(16)1294-9
PMID

Hiipakka M, Huotari P, Manninen A, Renkema GH, Saksela K
Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.
Virology 2001 ;286(1)152-9
PMID

Tamasauskas D, Powell V, Saksela K, Yazdanbakhsh K
A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.
Blood 2001 ;97(11)3651-4
PMID

Manninen A, Huotari P, Hiipakka M, Renkema GH, Saksela K
Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta.
J Virol 2001 ;75(6)3034-7
PMID

Renkema GH, Manninen A, Saksela K
Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX.
J Virol 2001 ;75(5)2154-60
PMID

Ikonen T, Matikainen M, Mononen N, Hyytinen ER, Helin HJ, Tommola S, Tammela TL, Pukkala E, Schleutker J, Kallioniemi OP, Koivisto PA
Association of E-cadherin germ-line alterations with prostate cancer.
Clin Cancer Res 2001 ;7(11)3465-71
PMID

Rokman A, Ikonen T, Mononen N, Autio V, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J
ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.
Cancer Res 2001 ;61(16)6038-41
PMID

Matikaine MP, Pukkala E, Schleutker J, Tammela TL, Koivisto P, Sankila R, Kallioniemi OP
Relatives of prostate cancer patients have an increased risk of prostate and stomach cancers: a population-based, cancer registry study in Finland.
Cancer Causes Control 2001 ;12(3)223-30
PMID

Mononen N, Ikonen T, Syrjakoski K, Matikainen M, Schleutker J, Tammela TL, Koivisto PA, Kallioniemi OP
A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland.
Br J Cancer 2001 ;84(10)1344-7
PMID

Rokman A, Koivisto PA, Matikainen MP, Kuukasjarvi T, Poutiainen M, Helin HJ, Karhu R, Kallioniemi OP, Schleutker J
Genetic changes in familial prostate cancer by comparative genomic hybridization.
Prostate 2001 ;46(3)233-9
PMID

Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, Santoro L, Toscano A, Fabrizi GM, Somer H, Croxen R, Beeson D, Poulton J, Suomalainen A, Jacobs HT, Zeviani M, Larsson C
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Nat Genet 2001 ;28(3)223-31
PMID

Saramaki O, Willi N, Bratt O, Gasser TC, Koivisto P, Nupponen NN, Bubendorf L, Visakorpi T
Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer.
Am J Pathol 2001 ;159(6)2089-94
PMID

Helenius MA, Saramaki OR, Linja MJ, Tammela TL, Visakorpi T
Amplification of urokinase gene in prostate cancer.
Cancer Res 2001 ;61(14)5340-4
PMID

Saramaki OR, Savinainen KJ, Nupponen NN, Bratt O, Visakorpi T
Amplification of hypoxia-inducible factor 1alpha gene in prostate cancer.
Cancer Genet Cytogenet 2001 ;128(1)31-4
PMID

Rhee HW, Zhau HE, Pathak S, Multani AS, Pennanen S, Visakorpi T, Chung LW
Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel.
In Vitro Cell Dev Biol Anim 2001 ;37(3)127-40
PMID

Isola J, Auvinen A, Poutiainen M, Kakkola L, Jarvinen TA, Maattanen L, Stenman UH, Tammela T, Hakama M, Visakorpi T
Predictors of biological aggressiveness of prostate specific antigen screening detected prostate cancer.
J Urol 2001 ;165(5)1569-74
PMID

Elo JP, Visakorpi T
Molecular genetics of prostate cancer.
Ann Med 2001 ;33(2)130-41
PMID

Linja MJ, Savinainen KJ, Saramaki OR, Tammela TL, Vessella RL, Visakorpi T
Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer.
Cancer Res 2001 ;61(9)3550-5
PMID

Loimas S, Toppinen MR, Visakorpi T, Janne J, Wahlfors J
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Cancer Gene Ther 2001 ;8(2)137-44
PMID

Porkka KP, Visakorpi T
Detection of differentially expressed genes in prostate cancer by combining suppression subtractive hybridization and cDNA library array.
J Pathol 2001 ;193(1)73-9
PMID

Pan Y, Lui WO, Nupponen N, Larsson C, Isola J, Visakorpi T, Bergerheim US, Kytola S
5q11, 8p11, and 10q22 are recurrent chromosomal breakpoints in prostate cancer cell lines.
Genes Chromosomes Cancer 2001 ;30(2)187-95
PMID

 
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