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IBT julkaisut 2002

NOTE: This list is not exhaustive because it has been collected by an automatic procedure from PubMed. It may also contain publications not related to IMT or Regea authors (authors having the same name). The same publication may also appear more than once in case several research groups have participated in the writing.
Bioinformatics
Mauno Vihinen - Bioinformatics Group
Lappalainen I, Vihinen M
Structural basis of ICF-causing mutations in the methyltransferase domain of DNMT3B.
Protein Eng 2002 ;15(12)1005-14
PMID

Riikonen P, Boberg J, Salakoski T, Vihinen M
Mobile access to biological databases on the Internet.
IEEE Trans Biomed Eng 2002 ;49(12)1477-9
PMID

Okoh MP, Kainulainen L, Heiskanen K, Isa MN, Varming K, Ruuskanen O, Vihinen M
Novel insertions of Bruton tyrosine kinase in patients with X-linked agammaglobulinemia.
Hum Mutat 2002 ;20(6)480-1
PMID

Hyytinen ER, Haapala K, Thompson J, Lappalainen I, Roiha M, Rantala I, Helin HJ, Jänne OA, Vihinen M, Palvimo JJ, Koivisto PA
Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer.
Lab Invest 2002 ;82(11)1591-8
PMID

Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S
Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Haematologica 2002 ;87(6)569-77
PMID

Ollila J, Vihinen M
Microarray analysis of B-cell stimulation.
Vitam Horm 2002 ;6477-99
PMID

Okoh MP, Vihinen M
Interaction between Btk TH and SH3 domain.
Biopolymers 2002 ;63(5)325-34
PMID

Väliaho J, Pusa M, Ylinen T, Vihinen M
IDR: the ImmunoDeficiency Resource.
Nucleic Acids Res 2002 ;30(1)232-4
PMID

Biotechnology
Vesa Hytönen - Protein Dynamics
Markku Kulomaa - Molecular Biotechnology
Laitinen OH, Hytönen VP, Ahlroth MK, Pentikäinen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS
Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin.
Biochem J 2002 ;363(Pt 3)609-17
PMID

Wang H, Marjomäki V, Ovod V, Kulomaa MS
Subcellular localization of pentachlorophenol 4-monooxygenase in Sphingobium chlorophenolicum ATCC 39723.
Biochem Biophys Res Commun 2002 ;299(5)703-9
PMID

Tiirola M, Valtonen ET, Rintamäki-Kinnunen P, Kulomaa MS
Diagnosis of flavobacteriosis by direct amplification of rRNA genes.
Dis Aquat Organ 2002 ;51(2)93-100
PMID

Tiirola MA, Wang H, Paulin L, Kulomaa MS
Evidence for natural horizontal transfer of the pcpB gene in the evolution of polychlorophenol-degrading sphingomonads.
Appl Environ Microbiol 2002 ;68(9)4495-501
PMID

Laitinen OH, Hytönen VP, Ahlroth MK, Pentikäinen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS
Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin.
Biochem J 2002 ;363(Pt 3)609-17
PMID

Karisola P, Alenius H, Mikkola J, Kalkkinen N, Helin J, Pentikäinen OT, Repo S, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS
The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy.
J Biol Chem 2002 ;277(25)22656-61
PMID

Tiirola MA, Männistö MK, Puhakka JA, Kulomaa MS
Isolation and characterization of Novosphingobium sp. strain MT1, a dominant polychlorophenol-degrading strain in a groundwater bioremediation system.
Appl Environ Microbiol 2002 ;68(1)173-80
PMID

Lehtolainen P, Taskinen A, Laukkanen J, Airenne KJ, Heino S, Lappalainen M, Ojala K, Marjomäki V, Martin JF, Kulomaa MS, Ylä-Herttuala S
Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules.
J Biol Chem 2002 ;277(10)8545-50
PMID

Cancer Groups
Jorma Isola - Cancer Biology
Anne Kallioniemi - Cancer Genomics
Tapio Visakorpi - Molecular Biology of Prostate Cancer
Johanna Schleutker - Genetic Predisposition to Cancer
Korsching E, Packeisen J, Agelopoulos K, Eisenacher M, Voss R, Isola J, van Diest PJ, Brandt B, Boecker W, Buerger H
Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis.
Lab Invest 2002 ;82(11)1525-33
PMID

Gancberg D, Järvinen T, di Leo A, Rouas G, Cardoso F, Paesmans M, Verhest A, Piccart MJ, Isola J, Larsimont D
Evaluation of HER-2/NEU protein expression in breast cancer by immunohistochemistry: an interlaboratory study assessing the reproducibility of HER-2/NEU testing.
Breast Cancer Res Treat 2002 ;74(2)113-20
PMID

Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.
Cancer Res 2002 ;62(16)4554-7
PMID

Karhu R, Vilpo L, Isola J, Knuutila S, Vilpo J
Cryopreserved chronic lymphocytic leukemia cells analyzed by multicolor fluorescence in situ hybridization after optimized mitogen stimulation.
Genes Chromosomes Cancer 2002 ;34(3)345-8
PMID

Kytölä S, Nord B, Elder EE, Carling T, Kjellman M, Cedermark B, Juhlin C, Höög A, Isola J, Larsson C
Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas.
Genes Chromosomes Cancer 2002 ;34(3)325-32
PMID

Di Leo A, Gancberg D, Larsimont D, Tanner M, Jarvinen T, Rouas G, Dolci S, Leroy JY, Paesmans M, Isola J, Piccart MJ
HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil.
Clin Cancer Res 2002 ;8(5)1107-16
PMID

Paunu N, Pukkala E, Laippala P, Sankila R, Isola J, Miettinen H, Simola KO, Helén P, Helin H, Haapasalo H
Cancer incidence in families with multiple glioma patients.
Int J Cancer 2002 ;97(6)819-22
PMID

Ristimäki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, Joensuu H, Isola J
Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.
Cancer Res 2002 ;62(3)632-5
PMID

Savinainen KJ, Saramäki OR, Linja MJ, Bratt O, Tammela TL, Isola JJ, Visakorpi T
Expression and gene copy number analysis of ERBB2 oncogene in prostate cancer.
Am J Pathol 2002 ;160(1)339-45
PMID

Akervall J, Borg A, Dictor M, Jin C, Jin Y, Tanner M, Isola J, Mertens F, Wennerberg J
Chromosomal translocations involving 11q13 contribute to cyclin D1 overexpression in squamous cell carcinoma of the head and neck.
Int J Oncol 2002 ;20(1)45-52
PMID

Kallioniemi A
Molecular signatures of breast cancer--predicting the future.
N Engl J Med 2002 ;347(25)2067-8
PMID

Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringnér M, Sauter G, Monni O, Elkahloun A, Kallioniemi OP, Kallioniemi A
Impact of DNA amplification on gene expression patterns in breast cancer.
Cancer Res 2002 ;62(21)6240-5
PMID

Mahlamäki EH, Bärlund M, Tanner M, Gorunova L, Höglund M, Karhu R, Kallioniemi A
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer.
Genes Chromosomes Cancer 2002 ;35(4)353-8
PMID

Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A
Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.
Genes Chromosomes Cancer 2002 ;35(4)311-7
PMID

Andersen CL, Monni O, Wagner U, Kononen J, Bärlund M, Bucher C, Haas P, Nocito A, Bissig H, Sauter G, Kallioniemi A
High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays.
Am J Pathol 2002 ;161(1)73-9
PMID

Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ, Appella E
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Nat Genet 2002 ;31(2)210-5
PMID

Varis A, Wolf M, Monni O, Vakkari ML, Kokkola A, Moskaluk C, Frierson H, Powell SM, Knuutila S, Kallioniemi A, El-Rifai W
Targets of gene amplification and overexpression at 17q in gastric cancer.
Cancer Res 2002 ;62(9)2625-9
PMID

Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A
New insights into testicular germ cell tumorigenesis from gene expression profiling.
Cancer Res 2002 ;62(8)2359-64
PMID

Mousses S, Kallioniemi A, Kauraniemi P, Elkahloun A, Kallioniemi OP
Clinical and functional target validation using tissue and cell microarrays.
Curr Opin Chem Biol 2002 ;6(1)97-101
PMID

Porkka KP, Helenius MA, Visakorpi T
Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.
Lab Invest 2002 ;82(11)1573-82
PMID

Laitinen S, Karhu R, Sawyers CL, Vessella RL, Visakorpi T
Chromosomal aberrations in prostate cancer xenografts detected by comparative genomic hybridization.
Genes Chromosomes Cancer 2002 ;35(1)66-73
PMID

Schulz WA, Elo JP, Florl AR, Pennanen S, Santourlidis S, Engers R, Buchardt M, Seifert HH, Visakorpi T
Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma.
Genes Chromosomes Cancer 2002 ;35(1)58-65
PMID

Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.
Cancer Res 2002 ;62(16)4554-7
PMID

Joki-Erkkilä MM, Karikoski R, Rantala I, Lenko HL, Visakorpi T, Heinonen PK
Gonadoblastoma and dysgerminoma associated with XY gonadal dysgenesis in an adolescent with chronic renal failure: a case of Frasier syndrome.
J Pediatr Adolesc Gynecol 2002 ;15(3)145-9
PMID

Porkka K, Saramäki O, Tanner M, Visakorpi T
Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays.
Lab Invest 2002 ;82(5)629-37
PMID

Leube B, Drechsler M, Mühlmann K, Schäfer R, Schulz WA, Santourlidis S, Anastasiadis A, Ackermann R, Visakorpi T, Müller W, Royer-Pokora B
Refined mapping of allele loss at chromosome 10q23-26 in prostate cancer.
Prostate 2002 ;50(3)135-44
PMID

Savinainen KJ, Saramäki OR, Linja MJ, Bratt O, Tammela TL, Isola JJ, Visakorpi T
Expression and gene copy number analysis of ERBB2 oncogene in prostate cancer.
Am J Pathol 2002 ;160(1)339-45
PMID

Mononen N, Ikonen T, Autio V, Rökman A, Matikainen MP, Tammela TL, Kallioniemi OP, Koivisto PA, Schleutker J
Androgen receptor CAG polymorphism and prostate cancer risk.
Hum Genet 2002 ;111(2)166-71
PMID

Rökman A, Ikonen T, Seppälä EH, Nupponen N, Autio V, Mononen N, Bailey-Wilson J, Trent J, Carpten J, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
Am J Hum Genet 2002 ;70(5)1299-304
PMID

Stephan DA, Howell GR, Teslovich TM, Coffey AJ, Smith L, Bailey-Wilson JE, Malechek L, Gildea D, Smith JR, Gillanders EM, Schleutker J, Hu P, Steingruber HE, Dhami P, Robbins CM, Makalowska I, Carpten JD, Sood R, Mumm S, Reinbold R, Bonner TI, Baffoe-Bonnie A, Bubendorf L, Heiskanen M, Kallioneimi OP, Baxevanis AD, Joseph SS, Zucchi I, Burk RD, Isaacs W, Ross MT, Trent JM
Physical and transcript map of the hereditary prostate cancer region at xq27.
Genomics 2002 ;79(1)41-50
PMID

Cellular Biology
Ari-Pekka Huovila - Cell Interactions
Herma Renkema - Biochemistry of Cell Signaling
Renkema GH, Pulkkinen K, Saksela K
Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.
Mol Cell Biol 2002 ;22(19)6719-25
PMID

Mitochondrial Genetics
Howy Jacobs - Mitochondrial Gene Expression and Disease Group
Hans Spelbrink - Molecular Biology-Mitochondrial DNA maintenance
Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT, Holt IJ
Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.
Cell 2002 ;111(4)495-505
PMID

Toompuu M, Yasukawa T, Suzuki T, Hakkinen T, Spelbrink JN, Watanabe K, Jacobs HT
The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.
J Biol Chem 2002 ;277(25)22240-50
PMID

Kajander OA, Karhunen PJ, Jacobs HT
The relationship between somatic mtDNA rearrangements, human heart disease and aging.
Hum Mol Genet 2002 ;11(3)317-24
PMID

Toompuu M, Yasukawa T, Suzuki T, Hakkinen T, Spelbrink JN, Watanabe K, Jacobs HT
The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.
J Biol Chem 2002 ;277(25)22240-50
PMID

Molecular Immunology
Mika Rämet - Experimental Immunology
Olli Silvennoinen - Molecular Immunology
Lahti M, Lofgren J, Marttila R, Renko M, Klaavuniemi T, Haataja R, Ramet M, Hallman M
Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection.
Pediatr Res 2002 ;51(6)696-9
PMID

Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
Nature 2002 ;416(6881)644-8
PMID

Löfgren J, Rämet M, Renko M, Marttila R, Hallman M
Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants.
J Infect Dis 2002 ;185(3)283-9
PMID

Rämet M, Lanot R, Zachary D, Manfruelli P
JNK signaling pathway is required for efficient wound healing in Drosophila.
Dev Biol 2002 ;241(1)145-56
PMID

Mäkelä T, Silvennoinen O
[Year 2002 Anders Jahre Young Scientist Award to Kalle Saksela].
Duodecim 2002 ;118(21)2161-2
PMID

Saharinen P, Silvennoinen O
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.
J Biol Chem 2002 ;277(49)47954-63
PMID

Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O
Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.
EMBO J 2002 ;21(18)4950-8
PMID

Pesu M, Aittomäki S, Takaluoma K, Lagerstedt A, Silvennoinen O
p38 Mitogen-activated protein kinase regulates interleukin-4-induced gene expression by stimulating STAT6-mediated transcription.
J Biol Chem 2002 ;277(41)38254-61
PMID

Olsen H, Hedengran Faulds MA, Saharinen P, Silvennoinen O, Haldosén LA
Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.
Biochem Biophys Res Commun 2002 ;296(1)139-44
PMID

Aittomäki S, Yang J, Scott EW, Simon MC, Silvennoinen O
Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.
Blood 2002 ;100(3)1078-80
PMID

Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.
Mol Cell Biol 2002 ;22(10)3316-26
PMID

 
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