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Lääketieteen ja biotieteiden tiedekuntaTampereen yliopisto BioMediTech

IBT julkaisut 2014



HUOMIO: Tämä luettelo ei ole ehdottoman täydellinen, koska se on koostettu automaattisesti PubMed-tietokannasta. Sama julkaisu voi esiintyä kahteen tai useampaan kertaan, koska aineisto koostetaan tutkimusryhmittäin. Luettelo voi myös sisältää artikkeita, jotka eivät ole BioMediTech:n tutkijoiden kirjoittamia johtuen samannimisistä kirjoittajista.
Biotechnology
Vesa Hytönen - Protein Dynamics
Markku Kulomaa - Molecular Biotechnology
Taskinen B, Zauner D, Lehtonen SI, Koskinen M, Thomson C, Kähkönen N, Kukkurainen S, Määttä JA, Ihalainen TO, Kulomaa MS, Gruber HJ, Hytönen VP
Switchavidin: reversible biotin-avidin-biotin bridges with high affinity and specificity.
Bioconjug Chem 2014 ;25(12)2233-43
PMID

Ribeiro C, Pärssinen J, Sencadas V, Correia V, Miettinen S, Hytönen VP, Lanceros-Méndez S
Dynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells.
J Biomed Mater Res A 2014 ;
PMID

Takala H, Lehtivuori H, Hammarén H, Hytönen VP, Ihalainen JA
Connection between Absorption Properties and Conformational Changes in Deinococcus radiodurans Phytochrome.
Biochemistry 2014 ;53(45)7076-85
PMID

Vuori L, Leppiniemi J, Hannula M, Lahtonen K, Hirsimäki M, Nõmmiste E, Costelle L, Hytönen VP, Valden M
Biofunctional hybrid materials: bimolecular organosilane monolayers on FeCr alloys.
Nanotechnology 2014 ;25(43)435603
PMID

Kukkurainen S, Määttä JA, Saeger J, Valjakka J, Vogel V, Hytönen VP
The talin-integrin interface under mechanical stress.
Mol Biosyst 2014 ;10(12)3217-28
PMID

Zolfaghari Emameh R, Barker H, Hytönen VP, Tolvanen ME, Parkkila S
Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry.
Parasit Vectors 2014 ;7403
PMID

Rosilo H, McKee JR, Kontturi E, Koho T, Hytönen VP, Ikkala O, Kostiainen MA
Cationic polymer brush-modified cellulose nanocrystals for high-affinity virus binding.
Nanoscale 2014 ;6(20)11871-81
PMID

Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE
Global analysis of human nonreceptor tyrosine kinase specificity using high-density Peptide microarrays.
J Proteome Res 2014 ;13(10)4339-46
PMID

Köhler M, Karner A, Leitner M, Hytönen VP, Kulomaa M, Hinterdorfer P, Ebner A
pH-dependent deformations of the energy landscape of avidin-like proteins investigated by single molecule force spectroscopy.
Molecules 2014 ;19(8)12531-46
PMID

Tossavainen H, Kukkurainen S, Määttä JA, Kähkönen N, Pihlajamaa T, Hytönen VP, Kulomaa MS, Permi P
Chimeric Avidin--NMR structure and dynamics of a 56 kDa homotetrameric thermostable protein.
PLoS One 2014 ;9(6)e100564
PMID

Kurppa K, Hytönen VP, Nakari-Setälä T, Kulomaa MS, Linder MB
Molecular engineering of avidin and hydrophobin for functional self-assembling interfaces.
Colloids Surf B Biointerfaces 2014 ;120102-9
PMID

Pärssinen J, Hammarén H, Rahikainen R, Sencadas V, Ribeiro C, Vanhatupa S, Miettinen S, Lanceros-Méndez S, Hytönen VP
Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride).
J Biomed Mater Res A 2014 ;
PMID

Pinon P, Pärssinen J, Vazquez P, Bachmann M, Rahikainen R, Jacquier MC, Azizi L, Määttä JA, Bastmeyer M, Hytönen VP, Wehrle-Haller B
Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.
J Cell Biol 2014 ;205(2)265-81
PMID

Taskinen B, Airenne TT, Jänis J, Rahikainen R, Johnson MS, Kulomaa MS, Hytönen VP
A novel chimeric avidin with increased thermal stability using DNA shuffling.
PLoS One 2014 ;9(3)e92058
PMID

Koho T, Koivunen MR, Oikarinen S, Kummola L, Mäkinen S, Mähönen AJ, Sioofy-Khojine A, Marjomäki V, Kazmertsuk A, Junttila I, Kulomaa MS, Hyöty H, Hytönen VP, Laitinen OH
Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.
Antiviral Res 2014 ;10493-101
PMID

Hytönen VP, Wehrle-Haller B
Protein conformation as a regulator of cell-matrix adhesion.
Phys Chem Chem Phys 2014 ;16(14)6342-57
PMID

Rangl M, Leitner M, Riihimäki T, Lehtonen S, Hytönen VP, Gruber HJ, Kulomaa M, Hinterdorfer P, Ebner A
Investigating the binding behaviour of two avidin-based testosterone binders using molecular recognition force spectroscopy.
J Mol Recognit 2014 ;27(2)92-7
PMID

Näreoja T, Ebner A, Gruber HJ, Taskinen B, Kienberger F, Hänninen PE, Hytönen VP, Hinterdorfer P, Härmä H
Kinetics of bioconjugate nanoparticle label binding in a sandwich-type immunoassay.
Anal Bioanal Chem 2014 ;406(2)493-503
PMID

Taskinen B, Zauner D, Lehtonen SI, Koskinen M, Thomson C, Kähkönen N, Kukkurainen S, Määttä JA, Ihalainen TO, Kulomaa MS, Gruber HJ, Hytönen VP
Switchavidin: reversible biotin-avidin-biotin bridges with high affinity and specificity.
Bioconjug Chem 2014 ;25(12)2233-43
PMID

Tossavainen H, Kukkurainen S, Määttä JA, Kähkönen N, Pihlajamaa T, Hytönen VP, Kulomaa MS, Permi P
Chimeric Avidin--NMR structure and dynamics of a 56 kDa homotetrameric thermostable protein.
PLoS One 2014 ;9(6)e100564
PMID

Kurppa K, Hytönen VP, Nakari-Setälä T, Kulomaa MS, Linder MB
Molecular engineering of avidin and hydrophobin for functional self-assembling interfaces.
Colloids Surf B Biointerfaces 2014 ;120102-9
PMID

Taskinen B, Airenne TT, Jänis J, Rahikainen R, Johnson MS, Kulomaa MS, Hytönen VP
A novel chimeric avidin with increased thermal stability using DNA shuffling.
PLoS One 2014 ;9(3)e92058
PMID

Koho T, Koivunen MR, Oikarinen S, Kummola L, Mäkinen S, Mähönen AJ, Sioofy-Khojine A, Marjomäki V, Kazmertsuk A, Junttila I, Kulomaa MS, Hyöty H, Hytönen VP, Laitinen OH
Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.
Antiviral Res 2014 ;10493-101
PMID

Cancer Groups
Jorma Isola - Cancer Biology
Anne Kallioniemi - Cancer Genomics

Barok M, Joensuu H, Isola J
Trastuzumab emtansine: mechanisms of action and drug resistance.
Breast Cancer Res 2014 ;16(2)209
PMID

Staff S, Tolonen T, Laasanen SL, Mecklin JP, Isola J, Mäenpää J
Quantitative analysis of γ-H2AX and p53 nuclear expression levels in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies in BRCA1 and BRCA2 mutation carriers.
Int J Gynecol Pathol 2014 ;33(3)309-16
PMID

Saarelainen SK, Staff S, Peltonen N, Lehtimäki T, Isola J, Kujala PM, Vuento MH, Mäenpää JU
Endoglin, VEGF, and its receptors in predicting metastases in endometrial carcinoma.
Tumour Biol 2014 ;35(5)4651-7
PMID

Kiiski JI, Pelttari LM, Khan S, Freysteinsdottir ES, Reynisdottir I, Hart SN, Shimelis H, Vilske S, Kallioniemi A, Schleutker J, Leminen A, Bützow R, Blomqvist C, Barkardottir RB, Couch FJ, Aittomäki K, Nevanlinna H
Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.
Proc Natl Acad Sci U S A 2014 ;111(42)15172-7
PMID

Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD, Tischkowitz M
Breast-cancer risk in families with mutations in PALB2.
N Engl J Med 2014 ;371(6)497-506
PMID

Wikman H, Westphal L, Schmid F, Pollari S, Kropidlowski J, Sielaff-Frimpong B, Glatzel M, Matschke J, Westphal M, Iljin K, Huhtala H, Terracciano L, Kallioniemi A, Sauter G, Müller V, Witzel I, Lamszus K, Kemming D, Pantel K
Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients.
Oncotarget 2014 ;5(10)3076-87
PMID

Heikkinen T, Khan S, Huovari E, Vilske S, Schleutker J, Kallioniemi A, Blomqvist C, Aittomäki K, Nevanlinna H
Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.
Breast Cancer Res Treat 2014 ;144(2)437-41
PMID

Laurila E, Vuorinen E, Savinainen K, Rauhala H, Kallioniemi A
KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro.
Exp Cell Res 2014 ;322(1)159-67
PMID

Prostate Cancer Research Center (PCRC)

Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D, , , , Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
Elife 2014 ;3
PMID

Fleischmann A, Saramäki OR, Zlobec I, Rotzer D, Genitsch V, Seiler R, Visakorpi T, Thalmann GN
Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers.
Prostate 2014 ;74(16)1647-54
PMID

Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO, Rand K, Wan P, Stram A, Sheng X, Pooler LC, Park K, Xia L, Tyrer J, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Goh C, Ahmed M, Govindasami K, Guy M, Tammela TL, Auvinen A, Wahlfors T, Schleutker J, Visakorpi T, Leinonen KA, Xu J, Aly M, Donovan J, Travis RC, Key TJ, Siddiq A, Canzian F, Khaw KT, Takahashi A, Kubo M, Pharoah P, Pashayan N, Weischer M, Nordestgaard BG, Nielsen SF, Klarskov P, Røder MA, Iversen P, Thibodeau SN, McDonnell SK, Schaid DJ, Stanford JL, Kolb S, Holt S, Knudsen B, Coll AH, Gapstur SM, Diver WR, Stevens VL, Maier C, Luedeke M, Herkommer K, Rinckleb AE, Strom SS, Pettaway C, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, Cannon-Albright L, Cybulski C, Wokołorczyk D, Kluźniak W, Park J, Sellers T, Lin HY, Isaacs WB, Partin AW, Brenner H, Dieffenbach AK, Stegmaier C, Chen C, Giovannucci EL, Ma J, Stampfer M, Penney KL, Mucci L, John EM, Ingles SA, Kittles RA, Murphy AB, Pandha H, Michael A, Kierzek AM, Blot W, Signorello LB, Zheng W, Albanes D, Virtamo J, Weinstein S, Nemesure B, Carpten J, Leske C, Wu SY, Hennis A, Kibel AS, Rybicki BA, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Batra J, Clements J, Spurdle A, Teixeira MR, Paulo P, Maia S, Slavov C, Kaneva R, Mitev V, Witte JS, Casey G, Gillanders EM, Seminara D, Riboli E, Hamdy FC, Coetzee GA, Li Q, Freedman ML, Hunter DJ, Muir K, Gronberg H, Neal DE, Southey M, Giles GG, Severi G, , , , , Cook MB, Nakagawa H, Wiklund F, Kraft P, Chanock SJ, Henderson BE, Easton DF, Eeles RA, Haiman CA
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Nat Genet 2014 ;46(10)1103-9
PMID

Scaravilli M, Asero P, Tammela TL, Visakorpi T, Saramäki OR
Mapping of the chromosomal amplification 1p21-22 in bladder cancer.
BMC Res Notes 2014 ;7547
PMID

Lázaro-Ibáñez E, Sanz-Garcia A, Visakorpi T, Escobedo-Lucea C, Siljander P, Ayuso-Sacido A, Yliperttula M
Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes.
Prostate 2014 ;74(14)1379-90
PMID

Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O'Meara S, Anderson E, Maddison M, Gamble S, , , , Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, van't Veer L, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent-Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes SM, Bova GS, Stratton MR, McDermott U, Campbell PJ
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Science 2014 ;345(6196)1251343
PMID

Annala M, Kivinummi K, Leinonen K, Tuominen J, Zhang W, Visakorpi T, Nykter M
DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.
EMBO Mol Med 2014 ;6(9)1121-3
PMID

Kristensen H, Haldrup C, Strand S, Mundbjerg K, Mortensen MM, Thorsen K, Ostenfeld MS, Wild PJ, Arsov C, Goering W, Visakorpi T, Egevad L, Lindberg J, Grönberg H, Høyer S, Borre M, Ørntoft TF, Sørensen KD
Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy.
Clin Cancer Res 2014 ;20(8)2169-81
PMID

Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.
Nat Genet 2014 ;46(2)126-35
PMID

Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T, Calin GA
Long noncoding RNA in prostate, bladder, and kidney cancer.
Eur Urol 2014 ;65(6)1140-51
PMID

Schrecengost RS, Dean JL, Goodwin JF, Schiewer MJ, Urban MW, Stanek TJ, Sussman RT, Hicks JL, Birbe RC, Draganova-Tacheva RA, Visakorpi T, DeMarzo AM, McMahon SB, Knudsen KE
USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.
Cancer Res 2014 ;74(1)272-86
PMID

Cuzick J, Thorat MA, Andriole G, Brawley OW, Brown PH, Culig Z, Eeles RA, Ford LG, Hamdy FC, Holmberg L, Ilic D, Key TJ, La Vecchia C, Lilja H, Marberger M, Meyskens FL, Minasian LM, Parker C, Parnes HL, Perner S, Rittenhouse H, Schalken J, Schmid HP, Schmitz-Dräger BJ, Schröder FH, Stenzl A, Tombal B, Wilt TJ, Wolk A
Prevention and early detection of prostate cancer.
Lancet Oncol 2014 ;15(11)e484-92
PMID

Nordström M, Wingren C, Rose C, Bjartell A, Becker C, Lilja H, Borrebaeck CA
Identification of plasma protein profiles associated with risk groups of prostate cancer patients.
Proteomics Clin Appl 2014 ;8(11-12)951-62
PMID

Vedder MM, de Bekker-Grob EW, Lilja HG, Vickers AJ, van Leenders GJ, Steyerberg EW, Roobol MJ
The Added Value of Percentage of Free to Total Prostate-specific Antigen, PCA3, and a Kallikrein Panel to the ERSPC Risk Calculator for Prostate Cancer in Prescreened Men.
Eur Urol 2014 ;66(6)1109-15
PMID

Nordström T, Vickers A, Assel M, Lilja H, Grönberg H, Eklund M
Comparison Between the Four-kallikrein Panel and Prostate Health Index for Predicting Prostate Cancer.
Eur Urol 2014 ;
PMID

Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Zappa M, Nelen V, Kwiatkowski M, Lujan M, Määttänen L, Lilja H, Denis LJ, Recker F, Paez A, Bangma CH, Carlsson S, Puliti D, Villers A, Rebillard X, Hakama M, Stenman UH, Kujala P, Taari K, Aus G, Huber A, van der Kwast TH, van Schaik RH, de Koning HJ, Moss SM, Auvinen A,
Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up.
Lancet 2014 ;384(9959)2027-35
PMID

Nazarian A, Lawlor K, Yi SS, Philip J, Ghosh M, Yaneva M, Villanueva J, Saghatelian A, Assel M, Vickers AJ, Eastham JA, Scher HI, Carver BS, Lilja H, Tempst P
Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
Mol Cell Proteomics 2014 ;13(11)3082-96
PMID

Bryant RJ, Lilja H
Emerging PSA-based tests to improve screening.
Urol Clin North Am 2014 ;41(2)267-76
PMID

Carlsson S, Assel M, Sjoberg D, Ulmert D, Hugosson J, Lilja H, Vickers A
Influence of blood prostate specific antigen levels at age 60 on benefits and harms of prostate cancer screening: population based cohort study.
BMJ 2014 ;348g2296
PMID

Stattin P, Carlsson S, Holmström B, Vickers A, Hugosson J, Lilja H, Jonsson H
Prostate cancer mortality in areas with high and low prostate cancer incidence.
J Natl Cancer Inst 2014 ;106(3)dju007
PMID

Taylor JM, Yaneva M, Velasco K, Philip J, Erdjument-Bromage H, Ostrovnaya I, Lilja HG, Bochner BH, Tempst P
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer.
Proteomics Clin Appl 2014 ;8(5-6)317-26
PMID

Vickers AJ, Sjoberg DD, Ulmert D, Vertosick E, Roobol MJ, Thompson I, Heijnsdijk EA, De Koning H, Atoria-Swartz C, Scardino PT, Lilja H
Empirical estimates of prostate cancer overdiagnosis by age and prostate-specific antigen.
BMC Med 2014 ;1226
PMID

Bancroft EK, Page EC, Castro E, Lilja H, Vickers A, Sjoberg D, Assel M, Foster CS, Mitchell G, Drew K, Mæhle L, Axcrona K, Evans DG, Bulman B, Eccles D, McBride D, van Asperen C, Vasen H, Kiemeney LA, Ringelberg J, Cybulski C, Wokolorczyk D, Selkirk C, Hulick PJ, Bojesen A, Skytte AB, Lam J, Taylor L, Oldenburg R, Cremers R, Verhaegh G, van Zelst-Stams WA, Oosterwijk JC, Blanco I, Salinas M, Cook J, Rosario DJ, Buys S, Conner T, Ausems MG, Ong KR, Hoffman J, Domchek S, Powers J, Teixeira MR, Maia S, Foulkes WD, Taherian N, Ruijs M, Helderman-van den Enden AT, Izatt L, Davidson R, Adank MA, Walker L, Schmutzler R, Tucker K, Kirk J, Hodgson S, Harris M, Douglas F, Lindeman GJ, Zgajnar J, Tischkowitz M, Clowes VE, Susman R, Ramón y Cajal T, Patcher N, Gadea N, Spigelman A, van Os T, Liljegren A, Side L, Brewer C, Brady AF, Donaldson A, Stefansdottir V, Friedman E, Chen-Shtoyerman R, Amor DJ, Copakova L, Barwell J, Giri VN, Murthy V, Nicolai N, Teo SH, Greenhalgh L, Strom S, Henderson A, McGrath J, Gallagher D, Aaronson N, Ardern-Jones A, Bangma C, Dearnaley D, Costello P, Eyfjord J, Rothwell J, Falconer A, Gronberg H, Hamdy FC, Johannsson O, Khoo V, Kote-Jarai Z, Lubinski J, Axcrona U, Melia J, McKinley J, Mitra AV, Moynihan C, Rennert G, Suri M, Wilson P, Killick E, , Moss S, Eeles RA
Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study.
Eur Urol 2014 ;66(3)489-99
PMID

Väänänen RM, Lilja H, Kauko L, Helo P, Kekki H, Cronin AM, Vickers AJ, Nurmi M, Alanen K, Bjartell A, Pettersson K
Cancer-associated changes in the expression of TMPRSS2-ERG, PCA3, and SPINK1 in histologically benign tissue from cancerous vs noncancerous prostatectomy specimens.
Urology 2014 ;83(2)511.e1-7
PMID

Vickers A, Carlsson S, Laudone V, Lilja H
It ain't what you do, it's the way you do it: five golden rules for transforming prostate-specific antigen screening.
Eur Urol 2014 ;66(2)188-90
PMID

Ahmad-Tajudin A, Adler B, Ekström S, Marko-Varga G, Malm J, Lilja H, Laurell T
MALDI-target integrated platform for affinity-captured protein digestion.
Anal Chim Acta 2014 ;8071-8
PMID

Sävblom C, Halldén C, Cronin AM, Säll T, Savage C, Vertosick EA, Klein RJ, Giwercman A, Lilja H
Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.
Clin Chem 2014 ;60(3)490-9
PMID

Danila DC, Anand A, Schultz N, Heller G, Wan M, Sung CC, Dai C, Khanin R, Fleisher M, Lilja H, Scher HI
Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival.
Eur Urol 2014 ;65(6)1191-7
PMID

Ankerst DP, Boeck A, Freedland SJ, Jones JS, Cronin AM, Roobol MJ, Hugosson J, Kattan MW, Klein EA, Hamdy F, Neal D, Donovan J, Parekh DJ, Klocker H, Horninger W, Benchikh A, Salama G, Villers A, Moreira DM, Schröder FH, Lilja H, Vickers AJ, Thompson IM
Evaluating the Prostate Cancer Prevention Trial High Grade Prostate Cancer Risk Calculator in 10 international biopsy cohorts: results from the Prostate Biopsy Collaborative Group.
World J Urol 2014 ;32(1)185-91
PMID

Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D, , , , Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
Elife 2014 ;3
PMID

Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O'Meara S, Anderson E, Maddison M, Gamble S, , , , Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, van't Veer L, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent-Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes SM, Bova GS, Stratton MR, McDermott U, Campbell PJ
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Science 2014 ;345(6196)1251343
PMID

Computational Biology
Matti Nykter - Computational Biology
Yang J, Annala M, Ji P, Wang G, Zheng H, Codgell D, Du X, Fang Z, Sun B, Nykter M, Chen K, Zhang W
Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.
J Hematol Oncol 2014 ;7(1)76
PMID

Annala M, Kivinummi K, Leinonen K, Tuominen J, Zhang W, Visakorpi T, Nykter M
DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.
EMBO Mol Med 2014 ;6(9)1121-3
PMID

Li X, Liu Y, Granberg KJ, Wang Q, Moore LM, Ji P, Gumin J, Sulman EP, Calin GA, Haapasalo H, Nykter M, Shmulevich I, Fuller GN, Lang FF, Zhang W
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma.
Oncogene 2014 ;
PMID

Ruusuvuori P, Lin J, Scott AC, Tan Z, Sorsa S, Kallio A, Nykter M, Yli-Harja O, Shmulevich I, Dudley AM
Quantitative analysis of colony morphology in yeast.
Biotechniques 2014 ;56(1)18-27
PMID

Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.
Nat Genet 2014 ;46(2)126-35
PMID

Liuksiala T, Teittinen KJ, Granberg K, Heinäniemi M, Annala M, Mäki M, Nykter M, Lohi O
Overexpression of SNORD114-3 marks acute promyelocytic leukemia.
Leukemia 2014 ;28(1)233-6
PMID

Mitochondrial Genetics
Howy Jacobs - Mitochondrial Gene Expression and Disease Group
Laurie Kaguni - Mitochondrial Biogenesis in Health and Disease
Alberto Sanz - Mitochondrial Gerontology and Age-related Diseases
Hans Spelbrink - Molecular Biology-Mitochondrial DNA maintenance
Holt IJ, Jacobs HT
Unique features of DNA replication in mitochondria: a functional and evolutionary perspective.
Bioessays 2014 ;36(11)1024-31
PMID

Kemppainen KK, Kemppainen E, Jacobs HT
The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.
G3 (Bethesda) 2014 ;4(10)2013-21
PMID

Gospodaryov DV, Lushchak OV, Rovenko BM, Perkhulyn NV, Gerards M, Tuomela T, Jacobs HT
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila.
Biochim Biophys Acta 2014 ;1837(11)1861-9
PMID

Fukuoh A, Cannino G, Gerards M, Buckley S, Kazancioglu S, Scialo F, Lihavainen E, Ribeiro A, Dufour E, Jacobs HT
Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase.
Mol Syst Biol 2014 ;10734
PMID

Vartiainen S, Chen S, George J, Tuomela T, Luoto KR, O'Dell KM, Jacobs HT
Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.
Dis Model Mech 2014 ;7(6)635-48
PMID

El-Khoury R, Kemppainen KK, Dufour E, Szibor M, Jacobs HT, Rustin P
Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives.
Br J Pharmacol 2014 ;171(8)2243-9
PMID

Kemppainen KK, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, Popplestone A, Singh S, Sanz A, Rustin P, Jacobs HT
Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.
Hum Mol Genet 2014 ;23(8)2078-93
PMID

Zabalza R, Nurminen A, Kaguni LS, Garesse R, Gallardo ME, Bornstein B
Co-occurrence of four nucleotide changes associated with an adult mitochondrial ataxia phenotype.
BMC Res Notes 2014 ;7883
PMID

Baqri RM, Pietron AV, Gokhale RH, Turner BA, Kaguni LS, Shingleton AW, Kunes S, Miller KE
Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.
Mech Ageing Dev 2014 ;141-142C35-45
PMID

Stiban J, Farnum GA, Hovde SL, Kaguni LS
The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNA.
J Biol Chem 2014 ;289(35)24032-42
PMID

Farnum GA, Nurminen A, Kaguni LS
Mapping 136 pathogenic mutations into functional modules in human DNA polymerase γ establishes predictive genotype-phenotype correlations for the complete spectrum of POLG syndromes.
Biochim Biophys Acta 2014 ;1837(7)1113-21
PMID

Mallikarjun V, Sriram A, Scialo F, Sanz A
The interplay between mitochondrial protein and iron homeostasis and its possible role in ageing.
Exp Gerontol 2014 ;56123-34
PMID

Kemppainen KK, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, Popplestone A, Singh S, Sanz A, Rustin P, Jacobs HT
Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.
Hum Mol Genet 2014 ;23(8)2078-93
PMID

Bharti SK, Sommers JA, Zhou J, Kaplan DL, Spelbrink JN, Mergny JL, Brosh RM
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
J Biol Chem 2014 ;289(43)29975-93
PMID

Busch KB, Kowald A, Spelbrink JN
Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?
Philos Trans R Soc Lond B Biol Sci 2014 ;369(1646)20130442
PMID

Aanen DK, Spelbrink JN, Beekman M
What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations.
Philos Trans R Soc Lond B Biol Sci 2014 ;369(1646)20130438
PMID

Rajala N, Gerhold JM, Martinsson P, Klymov A, Spelbrink JN
Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication.
Nucleic Acids Res 2014 ;42(2)952-67
PMID

Hensen F, Cansiz S, Gerhold JM, Spelbrink JN
To be or not to be a nucleoid protein: a comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins.
Biochimie 2014 ;100219-26
PMID

Molecular Immunology
Dan Hultmark - Genetic Immunology
Marko Pesu - Immunoregulation
Mika Rämet - Experimental Immunology
Schmid MR, Anderl I, Vesala L, Vanha-aho LM, Deng XJ, Rämet M, Hultmark D
Control of Drosophila blood cell activation via Toll signaling in the fat body.
PLoS One 2014 ;9(8)e102568
PMID

Rämet M, Hultmark D
Drosophila immunity--glorious past, dynamic present and exciting future.
Dev Comp Immunol 2014 ;42(1)1-2
PMID

Oksanen A, Aittomäki S, Jankovic D, Ortutay Z, Pulkkinen K, Hämäläinen S, Rokka A, Corthals GL, Watford WT, Junttila I, O'Shea JJ, Pesu M
Proprotein Convertase FURIN Constrains Th2 Differentiation and Is Critical for Host Resistance against Toxoplasma gondii.
J Immunol 2014 ;193(11)5470-9
PMID

Hammarén MM, Oksanen KE, Nisula HM, Luukinen BV, Pesu M, Rämet M, Parikka M
Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish.
PLoS Pathog 2014 ;10(6)e1004190
PMID

Hämäläinen S, Nurminen N, Ahlfors H, Oikarinen S, Sioofy-Khojine AB, Frisk G, Oberste MS, Lahesmaa R, Pesu M, Hyöty H
Coxsackievirus B1 reveals strain specific differences in plasmacytoid dendritic cell mediated immunogenicity.
J Med Virol 2014 ;86(8)1412-20
PMID

Aittomäki S, Pesu M
Therapeutic targeting of the Jak/STAT pathway.
Basic Clin Pharmacol Toxicol 2014 ;114(1)18-23
PMID

Huusko JM, Karjalainen MK, Mahlman M, Haataja R, Kari MA, Andersson S, Toldi G, Tammela O, Rämet M, Lavoie PM, Hallman M,
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia.
BMC Med Genet 2014 ;15120
PMID

Schmid MR, Anderl I, Vesala L, Vanha-aho LM, Deng XJ, Rämet M, Hultmark D
Control of Drosophila blood cell activation via Toll signaling in the fat body.
PLoS One 2014 ;9(8)e102568
PMID

Hammarén MM, Oksanen KE, Nisula HM, Luukinen BV, Pesu M, Rämet M, Parikka M
Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish.
PLoS Pathog 2014 ;10(6)e1004190
PMID

Kuuluvainen E, Hakala H, Havula E, Sahal Estimé M, Rämet M, Hietakangas V, Mäkelä TP
Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.
J Biol Chem 2014 ;289(23)16252-61
PMID

Myllymäki H, Valanne S, Rämet M
The Drosophila imd signaling pathway.
J Immunol 2014 ;192(8)3455-62
PMID

Huusko JM, Mahlman M, Karjalainen MK, Kaukola T, Haataja R, Marttila R, Toldi G, Szabó M, Kingsmore SF, Rämet M, Lavoie PM, Hallman M,
Polymorphisms of the gene encoding Kit ligand are associated with bronchopulmonary dysplasia.
Pediatr Pulmonol 2014 ;
PMID

Saralahti A, Piippo H, Parikka M, Henriques-Normark B, Rämet M, Rounioja S
Adult zebrafish model for pneumococcal pathogenesis.
Dev Comp Immunol 2014 ;42(2)345-53
PMID

Rämet M, Hultmark D
Drosophila immunity--glorious past, dynamic present and exciting future.
Dev Comp Immunol 2014 ;42(1)1-2
PMID

Regenerative Medicine
Katriina Aalto-Setälä - Cardiology Group
Susanna Miettinen - Adult Stem Cell Group
Susanna Narkilahti - Neuro Group
Heli Skottman - Eye Group
Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
Stem Cell Reports 2014 ;3(2)269-81
PMID

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Kärkkäinen S, Peuhkurinen K, Nieminen MS, Laakso M, , Kuusisto J
A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy.
Ann Med 2014 ;46(6)424-9
PMID

Ahola A, Kiviaho AL, Larsson K, Honkanen M, Aalto-Setälä K, Hyttinen J
Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation.
Biomed Eng Online 2014 ;1339
PMID

Vuorenpää H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T
Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes.
In Vitro Cell Dev Biol Anim 2014 ;50(4)275-86
PMID

Kreutzer J, Ikonen L, Hirvonen J, Pekkanen-Mattila M, Aalto-Setälä K, Kallio P
Pneumatic cell stretching system for cardiac differentiation and culture.
Med Eng Phys 2014 ;36(4)496-501
PMID

Patrikoski M, Sivula J, Huhtala H, Helminen M, Salo F, Mannerström B, Miettinen S
Different culture conditions modulate the immunological properties of adipose stem cells.
Stem Cells Transl Med 2014 ;3(10)1220-30
PMID

Kuismanen K, Sartoneva R, Haimi S, Mannerström B, Tomás E, Miettinen S, Nieminen K
Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study.
Stem Cells Transl Med 2014 ;3(8)936-41
PMID

Pärssinen J, Hammarén H, Rahikainen R, Sencadas V, Ribeiro C, Vanhatupa S, Miettinen S, Lanceros-Méndez S, Hytönen VP
Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride).
J Biomed Mater Res A 2014 ;
PMID

Björninen M, Siljander A, Pelto J, Hyttinen J, Kellomäki M, Miettinen S, Seppänen R, Haimi S
Comparison of chondroitin sulfate and hyaluronic Acid doped conductive polypyrrole films for adipose stem cells.
Ann Biomed Eng 2014 ;42(9)1889-900
PMID

Sándor GK, Numminen J, Wolff J, Thesleff T, Miettinen A, Tuovinen VJ, Mannerström B, Patrikoski M, Seppänen R, Miettinen S, Rautiainen M, Öhman J
Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects.
Stem Cells Transl Med 2014 ;3(4)530-40
PMID

Ylä-Outinen L, Joki T, Varjola M, Skottman H, Narkilahti S
Three-dimensional growth matrix for human embryonic stem cell-derived neuronal cells.
J Tissue Eng Regen Med 2014 ;8(3)186-94
PMID

Käpylä E, Sorkio A, Teymouri S, Lahtonen K, Vuori L, Valden M, Skottman H, Kellomäki M, Juuti-Uusitalo K
Ormocomp-modified glass increases collagen binding and promotes the adherence and maturation of human embryonic stem cell-derived retinal pigment epithelial cells.
Langmuir 2014 ;30(48)14555-65
PMID

Polinati P, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni TA
Patient specific induced pluripotent stem cells derived RPE cells: understanding the pathogenesis of retinopathy in LCHAD deficiency.
Invest Ophthalmol Vis Sci 2014 ;
PMID

Mikhailova A, Ilmarinen T, Uusitalo H, Skottman H
Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells.
Stem Cell Reports 2014 ;2(2)219-31
PMID

Sorkio A, Hongisto H, Kaarniranta K, Uusitalo H, Juuti-Uusitalo K, Skottman H
Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating.
Tissue Eng Part A 2014 ;20(3-4)622-34
PMID

Ylä-Outinen L, Joki T, Varjola M, Skottman H, Narkilahti S
Three-dimensional growth matrix for human embryonic stem cell-derived neuronal cells.
J Tissue Eng Regen Med 2014 ;8(3)186-94
PMID

 
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