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tampereen yliopisto: lääketieteen ja biotieteiden tiedekunta: julkaisut:
Lääketieteen ja biotieteiden tiedekuntaTampereen yliopisto BioMediTech

BMT julkaisut 2015



NOTE: This list is not exhaustive because it has been collected by an automatic procedure from PubMed. It may also contain publications not related to BioMediTech or authors (authors having the same name). The same publication may also appear more than once in case several research groups have participated in the writing.
Biotechnology
Vesa Hytönen - Protein Dynamics
Markku Kulomaa - Molecular Biotechnology
Orłowski A, Kukkurainen S, Pöyry A, Rissanen S, Vattulainen I, Hytönen VP, Róg T
PIP2 and Talin Join Forces to Activate Integrin.
J Phys Chem B 2015 ;119(38)12381-9
PMID

Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Atherosclerosis 2015 ;242(1)145-54
PMID

Koho T, Ihalainen TO, Stark M, Uusi-Kerttula H, Wieneke R, Rahikainen R, Blazevic V, Marjomäki V, Tampé R, Kulomaa MS, Hytönen VP
His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display.
Eur J Pharm Biopharm 2015 ;9622-31
PMID

Ray S, Steven RT, Green FM, Höök F, Taskinen B, Hytönen VP, Shard AG
Correction to "Neutralized Chimeric Avidin Binding at a Reference Biosensor Surface".
Langmuir 2015 ;31(22)6265
PMID

Pawlowski A, Moilanen AM, Rissanen IA, Määttä JA, Hytönen VP, Ihalainen JA, Bamford JK
The Minor Capsid Protein VP11 of Thermophilic Bacteriophage P23-77 Facilitates Virus Assembly by Using Lipid-Protein Interactions.
J Virol 2015 ;89(15)7593-603
PMID

Ray S, Steven RT, Green FM, Höök F, Taskinen B, Hytönen VP, Shard AG
Neutralized chimeric avidin binding at a reference biosensor surface.
Langmuir 2015 ;31(6)1921-30
PMID

Lehtonen SI, Taskinen B, Ojala E, Kukkurainen S, Rahikainen R, Riihimäki TA, Laitinen OH, Kulomaa MS, Hytönen VP
Efficient preparation of shuffled DNA libraries through recombination (Gateway) cloning.
Protein Eng Des Sel 2015 ;28(1)23-8
PMID

Ribeiro C, Pärssinen J, Sencadas V, Correia V, Miettinen S, Hytönen VP, Lanceros-Méndez S
Dynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells.
J Biomed Mater Res A 2015 ;103(6)2172-5
PMID

Pärssinen J, Hammarén H, Rahikainen R, Sencadas V, Ribeiro C, Vanhatupa S, Miettinen S, Lanceros-Méndez S, Hytönen VP
Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride).
J Biomed Mater Res A 2015 ;103(3)919-28
PMID

Koho T, Ihalainen TO, Stark M, Uusi-Kerttula H, Wieneke R, Rahikainen R, Blazevic V, Marjomäki V, Tampé R, Kulomaa MS, Hytönen VP
His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display.
Eur J Pharm Biopharm 2015 ;9622-31
PMID

Lehtonen SI, Taskinen B, Ojala E, Kukkurainen S, Rahikainen R, Riihimäki TA, Laitinen OH, Kulomaa MS, Hytönen VP
Efficient preparation of shuffled DNA libraries through recombination (Gateway) cloning.
Protein Eng Des Sel 2015 ;28(1)23-8
PMID

Cancer Groups
Jorma Isola - Cancer Biology
Anne Kallioniemi - Cancer Genomics
Daniela Ungureanu - Cancer Signaling

Tolonen T, Näpänkangas J, Isola J
[Clinical pathology on the verge of virtual microscopy].
Duodecim 2015 ;131(21)1981-7
PMID

Holmström O, Linder N, Lundin M, Moilanen H, Suutala A, Turkki R, Joensuu H, Isola J, Diwan V, Lundin J
Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner.
PLoS One 2015 ;10(12)e0144688
PMID

Laiho JE, Oikarinen S, Oikarinen M, Larsson PG, Stone VM, Hober D, Oberste S, Flodström-Tullberg M, Isola J, Hyöty H
Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology.
J Clin Virol 2015 ;69165-71
PMID

Tolonen TT, Isola J, Kaipia A, Riikonen J, Koivusalo L, Huovinen S, Laurila M, Porre S, Tirkkonen M, Kujala P
Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: an observational study.
BMC Clin Pathol 2015 ;154
PMID

Veskimäe K, Staff S, Tabaro F, Nykter M, Isola J, Mäenpää J
Microarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies.
Genes Chromosomes Cancer 2015 ;54(5)276-87
PMID

Vassilev B, Sihto H, Li S, Hölttä-Vuori M, Ilola J, Lundin J, Isola J, Kellokumpu-Lehtinen PL, Joensuu H, Ikonen E
Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.
Am J Pathol 2015 ;185(4)987-1000
PMID

Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H
Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci 2015 ;56(11)6265-74
PMID

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
J Biol Chem 2015 ;290(45)27261-70
PMID

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Proc Natl Acad Sci U S A 2015 ;112(15)4642-7
PMID

Prostate Cancer Research Center (PCRC)

Ylipää A, Kivinummi K, Kohvakka A, Annala M, Latonen L, Scaravilli M, Kartasalo K, Leppänen SP, Karakurt S, Seppälä J, Yli-Harja O, Tammela TL, Zhang W, Visakorpi T, Nykter M
Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.
Cancer Res 2015 ;75(19)4026-31
PMID

Rane JK, Ylipää A, Adamson R, Mann VM, Simms MS, Collins AT, Visakorpi T, Nykter M, Maitland NJ
Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.
Br J Cancer 2015 ;113(4)611-5
PMID

Kaukoniemi KM, Rauhala HE, Scaravilli M, Latonen L, Annala M, Vessella RL, Nykter M, Tammela TL, Visakorpi T
Epigenetically altered miR-193b targets cyclin D1 in prostate cancer.
Cancer Med 2015 ;4(9)1417-25
PMID

Martens-Uzunova ES, Hoogstrate Y, Kalsbeek A, Pigmans B, Vredenbregt-van den Berg M, Dits N, Nielsen SJ, Baker A, Visakorpi T, Bangma C, Jenster G
C/D-box snoRNA-derived RNA production is associated with malignant transformation and metastatic progression in prostate cancer.
Oncotarget 2015 ;6(19)17430-44
PMID

Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T
CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.
Oncotarget 2015 ;6(23)19661-70
PMID

Barfeld SJ, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi KM, Rennie PS, Ceder Y, Chabes A, Visakorpi T, Mills IG
Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.
Oncotarget 2015 ;6(14)12587-602
PMID

Zoni E, van der Horst G, van de Merbel AF, Chen L, Rane JK, Pelger RC, Collins AT, Visakorpi T, Snaar-Jagalska BE, Maitland NJ, van der Pluijm G
miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression.
Cancer Res 2015 ;75(11)2326-36
PMID

Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JM, Papaemmanuil E, Brewer DS, Kallio HM, Högnäs G, Annala M, Kivinummi K, Goody V, Latimer C, O'Meara S, Dawson KJ, Isaacs W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D, Whitaker HC, , Neal DE, Cooper CS, Eeles RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS
The evolutionary history of lethal metastatic prostate cancer.
Nature 2015 ;520(7547)353-7
PMID

Annala M, Kivinummi K, Tuominen J, Karakurt S, Granberg K, Latonen L, Ylipää A, Sjöblom L, Ruusuvuori P, Saramäki O, Kaukoniemi KM, Yli-Harja O, Vessella RL, Tammela TL, Zhang W, Visakorpi T, Nykter M
Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer.
Oncotarget 2015 ;6(8)6235-50
PMID

Scaravilli M, Porkka KP, Brofeldt A, Annala M, Tammela TL, Jenster GW, Nykter M, Visakorpi T
MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2.
Prostate 2015 ;75(8)798-805
PMID

Rane JK, Scaravilli M, Ylipää A, Pellacani D, Mann VM, Simms MS, Nykter M, Collins AT, Visakorpi T, Maitland NJ
MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets.
Eur Urol 2015 ;67(1)7-10
PMID

Antfolk M, Magnusson C, Augustsson P, Lilja H, Laurell T
Acoustofluidic, label-free separation and simultaneous concentration of rare tumor cells from white blood cells.
Anal Chem 2015 ;87(18)9322-8
PMID

Lee SW, Hosokawa K, Kim S, Jeong OC, Lilja H, Laurell T, Maeda M
A Highly Sensitive Porous Silicon (P-Si)-Based Human Kallikrein 2 (hK2) Immunoassay Platform toward Accurate Diagnosis of Prostate Cancer.
Sensors (Basel) 2015 ;15(5)11972-87
PMID

Larne O, Hagman Z, Lilja H, Bjartell A, Edsjö A, Ceder Y
miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.
Carcinogenesis 2015 ;36(8)858-66
PMID

Boström PJ, Bjartell AS, Catto JW, Eggener SE, Lilja H, Loeb S, Schalken J, Schlomm T, Cooperberg MR
Genomic Predictors of Outcome in Prostate Cancer.
Eur Urol 2015 ;68(6)1033-44
PMID

Grenvall C, Magnusson C, Lilja H, Laurell T
Concurrent isolation of lymphocytes and granulocytes using prefocused free flow acoustophoresis.
Anal Chem 2015 ;87(11)5596-604
PMID

Bryant RJ, Sjoberg DD, Vickers AJ, Robinson MC, Kumar R, Marsden L, Davis M, Scardino PT, Donovan J, Neal DE, Lilja H, Hamdy FC
Predicting high-grade cancer at ten-core prostate biopsy using four kallikrein markers measured in blood in the ProtecT study.
J Natl Cancer Inst 2015 ;107(7)
PMID

Antfolk M, Antfolk C, Lilja H, Laurell T, Augustsson P
A single inlet two-stage acoustophoresis chip enabling tumor cell enrichment from white blood cells.
Lab Chip 2015 ;15(9)2102-9
PMID

Gerdtsson A, Poon JB, Thorek DL, Mucci LA, Evans MJ, Scardino P, Abrahamsson PA, Nilsson P, Manjer J, Bjartell A, Malm J, Vickers A, Freedland SJ, Lilja H, Ulmert D
Anthropometric Measures at Multiple Times Throughout Life and Prostate Cancer Diagnosis, Metastasis, and Death.
Eur Urol 2015 ;68(6)1076-82
PMID

Stattin P, Vickers AJ, Sjoberg DD, Johansson R, Granfors T, Johansson M, Pettersson K, Scardino PT, Hallmans G, Lilja H
Improving the Specificity of Screening for Lethal Prostate Cancer Using Prostate-specific Antigen and a Panel of Kallikrein Markers: A Nested Case-Control Study.
Eur Urol 2015 ;68(2)207-13
PMID

Vilhelmsson-Timmermand O, Santos E, Thorek DL, Evans-Axelsson S, Bjartell A, Lilja H, Larson SM, Strand SE, Tran TA, Ulmert D
Radiolabeled antibodies in prostate cancer: a case study showing the effect of host immunity on antibody bio-distribution.
Nucl Med Biol 2015 ;42(4)375-80
PMID

Arnsrud Godtman R, Holmberg E, Lilja H, Stranne J, Hugosson J
Opportunistic testing versus organized prostate-specific antigen screening: outcome after 18 years in the Göteborg randomized population-based prostate cancer screening trial.
Eur Urol 2015 ;68(3)354-60
PMID

Larne O, Östling P, Haflidadóttir BS, Hagman Z, Aakula A, Kohonen P, Kallioniemi O, Edsjö A, Bjartell A, Lilja H, Lundwall Å, Ceder Y
miR-183 in prostate cancer cells positively regulates synthesis and serum levels of prostate-specific antigen.
Eur Urol 2015 ;68(4)581-8
PMID

Bratt O, Lilja H
Serum markers in prostate cancer detection.
Curr Opin Urol 2015 ;25(1)59-64
PMID

Nordström T, Vickers A, Assel M, Lilja H, Grönberg H, Eklund M
Comparison Between the Four-kallikrein Panel and Prostate Health Index for Predicting Prostate Cancer.
Eur Urol 2015 ;68(1)139-46
PMID

Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JM, Papaemmanuil E, Brewer DS, Kallio HM, Högnäs G, Annala M, Kivinummi K, Goody V, Latimer C, O'Meara S, Dawson KJ, Isaacs W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D, Whitaker HC, , Neal DE, Cooper CS, Eeles RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS
The evolutionary history of lethal metastatic prostate cancer.
Nature 2015 ;520(7547)353-7
PMID

Computational Biology
Matti Nykter - Computational Biology
The Cancer Genome Atlas Research Network
The Molecular Taxonomy of Primary Prostate Cancer.
Cell 2015 ;163(4)1011-25
PMID

Ylipää A, Kivinummi K, Kohvakka A, Annala M, Latonen L, Scaravilli M, Kartasalo K, Leppänen SP, Karakurt S, Seppälä J, Yli-Harja O, Tammela TL, Zhang W, Visakorpi T, Nykter M
Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.
Cancer Res 2015 ;75(19)4026-31
PMID

Rane JK, Ylipää A, Adamson R, Mann VM, Simms MS, Collins AT, Visakorpi T, Nykter M, Maitland NJ
Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.
Br J Cancer 2015 ;113(4)611-5
PMID

Nordfors K, Haapasalo J, Mäkelä K, Granberg KJ, Nykter M, Korja M, Paavonen T, Haapasalo H, Soini Y
Twist predicts poor outcome of patients with astrocytic glioma.
J Clin Pathol 2015 ;68(11)905-12
PMID

Kaukoniemi KM, Rauhala HE, Scaravilli M, Latonen L, Annala M, Vessella RL, Nykter M, Tammela TL, Visakorpi T
Epigenetically altered miR-193b targets cyclin D1 in prostate cancer.
Cancer Med 2015 ;4(9)1417-25
PMID

Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Nykter M, Hurme M
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression.
BMC Genomics 2015 ;16179
PMID

Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JM, Papaemmanuil E, Brewer DS, Kallio HM, Högnäs G, Annala M, Kivinummi K, Goody V, Latimer C, O'Meara S, Dawson KJ, Isaacs W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D, Whitaker HC, , Neal DE, Cooper CS, Eeles RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS
The evolutionary history of lethal metastatic prostate cancer.
Nature 2015 ;520(7547)353-7
PMID

Annala M, Kivinummi K, Tuominen J, Karakurt S, Granberg K, Latonen L, Ylipää A, Sjöblom L, Ruusuvuori P, Saramäki O, Kaukoniemi KM, Yli-Harja O, Vessella RL, Tammela TL, Zhang W, Visakorpi T, Nykter M
Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer.
Oncotarget 2015 ;6(8)6235-50
PMID

Turner KM, Sun Y, Ji P, Granberg KJ, Bernard B, Hu L, Cogdell DE, Zhou X, Yli-Harja O, Nykter M, Shmulevich I, Yung WK, Fuller GN, Zhang W
Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression.
Proc Natl Acad Sci U S A 2015 ;112(11)3421-6
PMID

Scaravilli M, Porkka KP, Brofeldt A, Annala M, Tammela TL, Jenster GW, Nykter M, Visakorpi T
MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2.
Prostate 2015 ;75(8)798-805
PMID

Veskimäe K, Staff S, Tabaro F, Nykter M, Isola J, Mäenpää J
Microarray analysis of differentially expressed genes in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies.
Genes Chromosomes Cancer 2015 ;54(5)276-87
PMID

Rane JK, Scaravilli M, Ylipää A, Pellacani D, Mann VM, Simms MS, Nykter M, Collins AT, Visakorpi T, Maitland NJ
MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets.
Eur Urol 2015 ;67(1)7-10
PMID

Li X, Liu Y, Granberg KJ, Wang Q, Moore LM, Ji P, Gumin J, Sulman EP, Calin GA, Haapasalo H, Nykter M, Shmulevich I, Fuller GN, Lang FF, Zhang W
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma.
Oncogene 2015 ;34(13)1619-28
PMID

Mitochondrial Genetics
Howy Jacobs - Mitochondrial Gene Expression and Disease Group
Laurie Kaguni - Mitochondrial Biogenesis in Health and Disease
Hans Spelbrink - Molecular Biology-Mitochondrial DNA maintenance
Syrjänen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Rämet M, Parkkila S
β carbonic anhydrase is required for female fertility in Drosophila melanogaster.
Front Zool 2015 ;1219
PMID

Holmes JB, Akman G, Wood SR, Sakhuja K, Cerritelli SM, Moss C, Bowmaker MR, Jacobs HT, Crouch RJ, Holt IJ
Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.
Proc Natl Acad Sci U S A 2015 ;112(30)9334-9
PMID

Lewis SC, Joers P, Willcox S, Griffith JD, Jacobs HT, Hyman BC
A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.
PLoS Genet 2015 ;11(2)e1004985
PMID

Ciesielski GL, Bermek O, Rosado-Ruiz FA, Hovde SL, Neitzke OJ, Griffith JD, Kaguni LS
Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.
J Biol Chem 2015 ;290(48)28697-707
PMID

Oliveira MT, Haukka J, Kaguni LS
Evolution of the metazoan mitochondrial replicase.
Genome Biol Evol 2015 ;7(4)943-59
PMID

Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN
Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure.
Sci Rep 2015 ;515292
PMID

Fernández-Millán P, Lázaro M, Cansız-Arda Ş, Gerhold JM, Rajala N, Schmitz CA, Silva-Espiña C, Gil D, Bernadó P, Valle M, Spelbrink JN, Solà M
The hexameric structure of the human mitochondrial replicative helicase Twinkle.
Nucleic Acids Res 2015 ;43(8)4284-95
PMID

Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A
The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.
Sci Rep 2015 ;59149
PMID

Rajala N, Hensen F, Wessels HJ, Ives D, Gloerich J, Spelbrink JN
Whole cell formaldehyde cross-linking simplifies purification of mitochondrial nucleoids and associated proteins involved in mitochondrial gene expression.
PLoS One 2015 ;10(2)e0116726
PMID

Wortmann SB, Ziętkiewicz S, Kousi M, Szklarczyk R, Haack TB, Gersting SW, Muntau AC, Rakovic A, Renkema GH, Rodenburg RJ, Strom TM, Meitinger T, Rubio-Gozalbo ME, Chrusciel E, Distelmaier F, Golzio C, Jansen JH, van Karnebeek C, Lillquist Y, Lücke T, Õunap K, Zordania R, Yaplito-Lee J, van Bokhoven H, Spelbrink JN, Vaz FM, Pras-Raves M, Ploski R, Pronicka E, Klein C, Willemsen MA, de Brouwer AP, Prokisch H, Katsanis N, Wevers RA
CLPB mutations cause 3-methylglutaconic aciduria, progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder.
Am J Hum Genet 2015 ;96(2)245-57
PMID

Molecular Immunology
Dan Hultmark - Genetic Immunology
Marko Pesu - Immunoregulation
Mika Rämet - Experimental Immunology
Yang H, Kronhamn J, Ekström JO, Korkut GG, Hultmark D
JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection.
EMBO Rep 2015 ;16(12)1664-72
PMID

Vanha-Aho LM, Anderl I, Vesala L, Hultmark D, Valanne S, Rämet M
Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster.
PLoS Pathog 2015 ;11(5)e1004895
PMID

Anderl I, Hultmark D
New ways to make a blood cell.
Elife 2015 ;4
PMID

Ortutay Z, Oksanen A, Aittomäki S, Ortutay C, Pesu M
Proprotein convertase FURIN regulates T cell receptor-induced transactivation.
J Leukoc Biol 2015 ;98(1)73-83
PMID

Turpeinen H, Seppälä I, Lyytikäinen LP, Raitoharju E, Hutri-Kähönen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kähönen M, Lehtimäki T, Pesu M
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Hum Genet 2015 ;134(6)627-36
PMID

Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M
The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Infect Immun 2015 ;83(4)1431-42
PMID

Hömmö T, Pesu M, Moilanen E, Korhonen R
Regulation of Inflammatory Cytokine Production by MKP-5 in Macrophages.
Basic Clin Pharmacol Toxicol 2015 ;117(2)96-104
PMID

Syrjänen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Rämet M, Parkkila S
β carbonic anhydrase is required for female fertility in Drosophila melanogaster.
Front Zool 2015 ;1219
PMID

Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bäuerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, Rämet M, Parkkila S
Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish.
PLoS One 2015 ;10(7)e0134263
PMID

Karjalainen MK, Ojaniemi M, Haapalainen AM, Mahlman M, Salminen A, Huusko JM, Määttä TA, Kaukola T, Anttonen J, Ulvila J, Haataja R, Teramo K, Kingsmore SF, Palotie A, Muglia LJ, Rämet M, Hallman M
CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth.
J Immunol 2015 ;195(5)2187-98
PMID

Myllymäki H, Niskanen M, Oksanen KE, Rämet M
Animal models in tuberculosis research - where is the beef?
Expert Opin Drug Discov 2015 ;10(8)871-83
PMID

Mahlman M, Huusko JM, Karjalainen MK, Kaukola T, Marttila R, Ojaniemi M, Haataja R, Lavoie PM, Rämet M, Hallman M,
Genes Encoding Vascular Endothelial Growth Factor A (VEGF-A) and VEGF Receptor 2 (VEGFR-2) and Risk for Bronchopulmonary Dysplasia.
Neonatology 2015 ;108(1)53-9
PMID

Vanha-Aho LM, Anderl I, Vesala L, Hultmark D, Valanne S, Rämet M
Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster.
PLoS Pathog 2015 ;11(5)e1004895
PMID

Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M
The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Infect Immun 2015 ;83(4)1431-42
PMID

Regenerative Medicine
Katriina Aalto-Setälä - Cardiology Group
Susanna Miettinen - Adult Stem Cell Group
Susanna Narkilahti - Neuro Group
Heli Skottman - Eye Group
Kartasalo K, Pölönen RP, Ojala M, Rasku J, Lekkala J, Aalto-Setälä K, Kallio P
CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels.
BMC Bioinformatics 2015 ;16344
PMID

Manzini S, Viiri LE, Marttila S, Aalto-Setälä K
A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production.
Stem Cell Rev 2015 ;11(6)900-8
PMID

Penttinen K, Siirtola H, Àvalos-Salguero J, Vainio T, Juhola M, Aalto-Setälä K
Novel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes.
PLoS One 2015 ;10(8)e0135806
PMID

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K
Correction: Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.
PLoS One 2015 ;10(7)e0134746
PMID

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.
PLoS One 2015 ;10(5)e0125366
PMID

Juhola M, Penttinen K, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Siirtola H, Iltanen K, Laurikkala J, Hyyrö H, Hyttinen J, Aalto-Setälä K
Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes.
Comput Biol Med 2015 ;611-7
PMID

Zhao MD, Björninen M, Cao L, Wang HR, Pelto J, Li XQ, Hyttinen J, Jiang YQ, Kellomäki M, Miettinen S, Sándor GK, Seppänen R, Haimi S, Dong J
Polypyrrole coating on poly-(lactide/glycolide)-β-tricalcium phosphate screws enhances new bone formation in rabbits.
Biomed Mater 2015 ;10(6)065016
PMID

Vanhatupa S, Ojansivu M, Autio R, Juntunen M, Miettinen S
Bone Morphogenetic Protein-2 Induces Donor-Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells.
Stem Cells Transl Med 2015 ;4(12)1391-402
PMID

Ojansivu M, Vanhatupa S, Björkvik L, Häkkänen H, Kellomäki M, Autio R, Ihalainen JA, Hupa L, Miettinen S
Bioactive glass ions as strong enhancers of osteogenic differentiation in human adipose stem cells.
Acta Biomater 2015 ;21190-203
PMID

Hunter DJ, Bardet C, Mouraret S, Liu B, Singh G, Sadoine J, Dhamdhere G, Smith A, Tran XV, Joy A, Rooker S, Suzuki S, Vuorinen A, Miettinen S, Chaussain C, Helms JA
Wnt Acts as a Prosurvival Signal to Enhance Dentin Regeneration.
J Bone Miner Res 2015 ;30(7)1150-9
PMID

Pärssinen J, Hammarén H, Rahikainen R, Sencadas V, Ribeiro C, Vanhatupa S, Miettinen S, Lanceros-Méndez S, Hytönen VP
Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride).
J Biomed Mater Res A 2015 ;103(3)919-28
PMID

Ahtiainen K, Sippola L, Nurminen M, Mannerström B, Haimi S, Suuronen R, Hyttinen J, Ylikomi T, Kellomäki M, Miettinen S
Effects of chitosan and bioactive glass modifications of knitted and rolled polylactide-based 96/4 L/D scaffolds on chondrogenic differentiation of adipose stem cells.
J Tissue Eng Regen Med 2015 ;9(1)55-65
PMID

Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H
Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium.
PLoS One 2015 ;10(11)e0143669
PMID

Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H
Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci 2015 ;56(11)6265-74
PMID

Mikhailova A, Jylhä A, Rieck J, Nättinen J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H
Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells.
Sci Rep 2015 ;514684
PMID

Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS
Human iPSC derived disease model of MERTK-associated retinitis pigmentosa.
Sci Rep 2015 ;512910
PMID

Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S
Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells.
PLoS One 2015 ;10(6)e0128434
PMID

Polinati PP, Ilmarinen T, Trokovic R, Hyotylainen T, Otonkoski T, Suomalainen A, Skottman H, Tyni T
Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency.
Invest Ophthalmol Vis Sci 2015 ;56(5)3371-82
PMID

Sorkio A, Porter PJ, Juuti-Uusitalo K, Meenan BJ, Skottman H, Burke GA
Surface Modified Biodegradable Electrospun Membranes as a Carrier for Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Tissue Eng Part A 2015 ;21(17-18)2301-14
PMID

Sorkio AE, Vuorimaa-Laukkanen EP, Hakola HM, Liang H, Ujula TA, Valle-Delgado JJ, Österberg M, Yliperttula ML, Skottman H
Biomimetic collagen I and IV double layer Langmuir-Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells.
Biomaterials 2015 ;51257-69
PMID

 
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