Arvo building, auditorium F114, address: Lääkärinkatu 1.
Doctoral defence of MSc Reza Zolfaghari Emameh
The field of science of the dissertation is Medical technology and biotechnology.
The opponent is Associate professor Jan Andersson (Uppsala University, Sweden). Professor Seppo Parkkila acts as the custos.
The language of the dissertation defence is English.
β-Carbonic Anhydrases: Novel targets for diagnosis and treatment of parasitic infections
Carbonic anhydrases (CAs) are metalloenzymes, which are classified in six different families: α, β, γ, δ, ζ, and η. These enzymes are critical in many physiological and biochemical functions of living organisms. β-CAs are present in some parasites, such as insects and nematodes, but absent in humans and other mammals. Therefore, β-CAs are proposed as potential targets for diagnostics and treatment of parasitic infections with minimal side effects on humans.
In this study, we identified 52 new β-CAs from parasites and produced a β-CA enzyme from Ascaris nematode in insect cells by genetic engineering. We also developed a diagnostic method based on the presence of the β-CA gene in Trichinella nematode.
The most recent studies from our laboratory showed that β-CA genes in insects and nematodes have originated from bacteria during the long history of evolution.
The dissertation is published in the publication series of Acta Universitatis Tamperensis; 2217, Tampere University Press, Tampere 2016. ISBN 978-952-03-0241-2, ISSN 1455-1616. The dissertation is also published in the e-series Acta Electronica Universitatis Tamperensis; 1717, Tampere University Press 2016. ISBN 978-952-03-0242-9, ISSN 1456-954X.