Arvo building, auditorium F114, address: Lääkärinkatu 1
Doctoral defence of Lic.Med. Olli Nevalainen
The field of science of the dissertation is Epidemiology.
The opponent is Professor Torbjörn Tomson (Karolinska Institutet, Sweden). Professor Anssi Auvinen acts as the custos.
The language of the dissertation defence is English.
Mortality in Epilepsy with Emphasis on Clinical Features
Epilepsy is a common, chronic neurological disease that is associated with a reduced life expectancy in comparison to individuals without epilepsy. Excess mortality in epilepsy has been partly explained by brain diseases that may cause epilepsy, in addition to higher incidence of cancers, accidents, suicides, and sudden unexpected deaths associated with active epilepsy.
The material of this thesis is based on two Finnish cohort studies and two systematic literature reviews. In a nationwide cohort study epilepsy patients had a three-fold mortality risk in comparison to the reference population. The quantitative synthesis of the published studies by clinical characteristics of epilepsy showed that excess mortality was related to symptomatic and cryptogenic etiologies of epilepsy, as well as higher seizure frequency. Individuals with idiopathic epilepsy had a mortality rate comparable to that of the general population.
The dissertation is published in the publication series of Acta Universitatis Tamperensis; 2241, Tampere University Press, Tampere 2016. ISBN 978-952-03-0297-9, ISSN 1455-1616. The dissertation is also published in the e-series Acta Electronica Universitatis Tamperensis; 1741, Tampere University Press 2016. ISBN 978-952-03-0298-6, ISSN 1456-954X.