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Vitality 90 + Study
Tervaskannot 90+

By Antti Hervonen, Marja Jylhä and the Research Group
School of Health Sciences, FIN 33014-University of Tampere, Finland

Tervaskannot 90+ GEREC sivuilla
Vitality 90+ (GEREC webpage)


· Describes the life conditions, ways of life, biological and clinical   characteristics and heterogeneity of the most rapidly growing age group
· Examines physical and psychological functioning and their predictors
· Analyses life stories and personal accounts of the oldest generation alive
· Searches for possibilities and pathways for successful longevity

Data sets

· Mailed surveys with total home-dwelling population aged 90+ in Tampere  in 1995, 1996 and 1998
· Mailed survey with total population, both home-dwelling and institutionalized, aged 90+ in Tampere in 2001, 2003, 2007, 2010 and 2014
· Register data of instutionalization and mortality
· Oral tape-recorded life stories & narrative interviews with 245 persons aged 90+ in Tampere in 1995 and 2012
· Psychological examinations with 100 persons
· Phone interviews with informal caregivers and family members
· History of disease; data from medical records
· Home-examinations, including functional performance, cognitive status and blood tests for people aged 89-90 in 2000, 2010, 2014, and home-examination without blood tests in 2003.
· Biomarkers
· Analysis of genetic factors associated with exceptional longevity

The advantages of the Vitality 90+ Study

· Covers the total population aged 90+ in Tampere (N= 1129 in 2001, N=1113 in 2003, N=1147 in 2007, N=1606 in 2010 and N=2056 in 2014). Response rates vary in mailed surveys from 79 to 86%
· Social, demographic, biological and clinical measures available for same individuals
· Longitudinal approach, complete mortality follow-up
· Epidemiological, clinical and qualitative approaches combined



Enroth Linda, Raitanen Jani, Hervonen Antti, Lehtimäki Terho, Jylhävä Juulia, Hurme Mikko, Jylhä Marja. (2016). Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. (71) 3, 412–419. doi:10.1093/gerona/glv105

Jylhävä J, Kananen L, Raitanen J, Marttila S, Nevalainen T, Hervonen A, Jylhä M, Hurme M. (2016 Po methylomic predictors demonstrate the role of NF-kB in old age mortality and are unrelated to the ageing-associated epigenetic drift. Oncotarget 22, doi: 10.18632/oncotarget.8278 PMID 27015558


Enroth Linda, Raitanen Jani, Hervonen Antti, Nosraty Lily, Jylhä Marja. (2015). Is socioeconomic status a predictor of mortality in nonagenarians? The vitality 90+ study. Age and Ageing 44 (1), 123-129.

Jylhä Marja, Enroth Linda, Forma Leena. (2015). Sotainvalidien elämäntilanne ja terveys yli 90-vuotiaana? Tervaskannot 90+ -tutkimuksen tuloksia. Teoksessa Tutkijafoorumi. Sotainvalidien Veljesliitto 75 vuotta, 6-11.

Kananen Laura, Nevalainen Tapio, Jylhäva Juulia, Marttila Saara, Hervonen Antti, Jylha Marja, Hurme Mikko. (2015). Cytomegalovirus infection accelerates epigenetic aging. Experimental Gerontology 72 (Suppl C), 227-229.

Marttila Saara, Kananen Laura, Häyrynen Sergei, Jylhävä Juulia, Nevalainen Tapio, Hervonen Antti, Jylhä Marja, Nykter Matti, Hurme Mikko. (2015). Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics 16, 179.

Marttila Saara, Kananen Laura, Jylhävä Juulia, Nevalainen Tapio, Hervonen Antti, Jylhä Marja, Hurme Mikko. (2015). Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. Oncotarget 6 (31), 30557-67.

Marttila Saara, Nevalainen Tapio, Kananen Laura, Jylhävä Juulia, Jylhä Marja, Hervonen Antti, Ilonen Jorma, Hurme Mikko. (2015). Number of sons contributes to ageing-associated inflammation. Scientific Reports 5, 8631.

Nevalainen T, Kananen L, Marttila S, Jylhä M, Hervonen A, Hurme M, Jylhävä J. (2015). Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study. AGE 37 (4), 76.

Nosraty Lily, Enroth Linda, Raitanen Jani, Hervonen Antti, Jylhä Marja. (2015). Do Successful Agers Live Longer? The Vitality 90+ Study. Journal of Aging and Health 27 (1), 35-53.

Nosraty Lily, Jylhä Marja, RaittilaTaina, Lumme-Sandt Kirsi. (2015). Perceptions by the oldest old of successful aging, Vitality 90+ Study. Journal of Aging Studies 32, 50-58.

Pirhonen Jari, Ojala Hanna, Lumme-Sandt Kirsi, Pietilä Ilkka. (2015). 'Old but not that old': Finnish community-dwelling people aged 90+ negotiating their autonomy. Ageing and Society.

Tiainen Kristina, Raitanen Jani, Vaara Elina, Hervonen Antti, Jylhä Marja. (2015). Longitudinal changes in mobility among nonagenarians: the Vitality 90+ Study. BMC Geriatrics 15 (124), -:124.


Jylhävä Juulia, Raitanen Jani, Marttila Saara, Hervonen Antti, Jylhä Marja, Hurme Mikko. (2014). Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study. BMC Medical Genomics 7 (54).

Lisko Inna, Stenholm Sari, Raitanen Jani, Hurme Mikko, Hervonen Antti, Jylhä Marja, Tiainen Kristiina. (2014). Association of Body Mass Index and Waist Circumference With Physical Functioning: The Vitality 90+ Study. Journal of Gerontology A Biological Sciences and Medical Sciences.

Marttila Saara, Jylhävä Juulia, Kananen Laura, Hervonen Antti, Jylhä Marja, Hurme Mikko. (2014). Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians. Immunity & Ageing 11, 2

2013 and earlier

Marttila S,    Jylhava J,    Nevalainen T,    Nykter M,    Jylha M,    Hervonen A,    Tserel L,   Peterson P,    Hurme M.Transcriptional Analysis Reveals Gender-Specific Changes in the Aging of the Human Immune System. PLos One 2013, Jun 11;8(6), journal.pone.0066229

Tiainen K, Luukkaala T, Hervonen A, Jylhä M. Predictors of mortality in men and women aged 90 years and older: nine-year follow-up. Age & Ageing 42:468-475, 2013.  doi:10.1093/ageing/aft030t PubMed 

Aaltonen M, Forma L, Rissanen P, Raitanen J, Jylhä M. Effects of municipality factors on care transitions. Scandinavian Journal of Public Health 41:604-615, 2013, epub ahead of printing DOI:10:1177/1403494813484396

Enroth L, Raitanen J, Hervonen A, Jylhä M. Do socioeconomic health differences persist in nonagenarians. J Gerontol Psych Sci Soc Sci. 68(5):837-847, 2013. doi: 10.1093/geronh/gbt067

Galenkamp H, Deeg DJH, Huisman M, Hervonen A, Braam AW, Jylhä M. Is self-rated health still sensitive for changes in disease and functioning among nonagenarians? J Gerontol Psych Sci Soc Sci   68(5):848-858. 2013. doi: 10.1093/geronh/gbt067

Jylha M. Enroth L and Luukkaala T.  Trends of functioning and health in nonagenarians- the Vitality 90+ Study. In Robine JM, Jagger C, Crimmins E. Annual Review of Gerontology and Geriatrics, vol 33, 2013 ”Healthy Longevity”. Springer Publishing Company, pp- 313-332

Helminen S, Sarkeala T, Enroth L, Hervonen A, Jylhä M. Vanhoista vanhiimpien terveys ja elämätilanne. Tuloksia vuoden 201 Tervskannot 90+- tutkimuksesta. Gerontologia 26(3):162-171, 2012

Vuorisalmi M, Sarkeala T, Hervonen A, Jylhä M. Among nonagenarians, congruence between self-rated health and proxy-rated health was low but both predicted mortality. J Clin Epidemiol 65:553-559, 2012, doi: 10 1016/jclinepi.2011.11001

Jylhävä J, Jylhä M, Lehtimäki T, Hervonen A, Hurme M. Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians. Exp Gerontol 47(5);372-8,Epub 2012 Mar 3, PMID:22406558

Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hurme M, Lehtimäki T, Hervonen A, Jylhä M. Inflammation, adiposity and mortality in the oldest old. Rejuvenation Research 15(5):445-452, 2012. DOI:10.1089/rej.2011.1310. Epub 2012 Sep 21

Nosraty L, Hervonen A, Jylhä M. Is there successful aging for nonagenarians? Vitality 90+ study. Journal of Aging Research, 2012;2012:868797. doi:10.1155/2012/868797. Epub 2012 Oct 16. PubMed PMID: 23125931

Sarkeala T, Nummi T, Vuorisalmi M, Hervonen A, Jylhä M. Disability trends among nonagenarians in 2001-2007: Vitality 90 study. Eur J Ageing 8 (2) : 87-94, 2011 DOI 10.1007/s10433-011-0188-2.

Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hervonen A, Jylhä M. Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: the Vitality 90+ Study. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1244-50. Epub 2011 Aug 22. PubMed PMID: 21860016

Jylhävä J, Kotipelto T, Raitala A, Jylhä M, Hervonen A, Hurme M. Ageing is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ Study. Mech Ageing Dev 132:20-26, 2011, epub ahead of printing doi:10.1016/j.mad.2010.11.001

Jylhävä J, Eklund C, Jylhä M, Hervonen A, Lehtimäki T, Karhunen P, Hurme M.Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: The Vitality 90+ study. Exp Gerontol. 2008 Oct 26. [Epub ahead of print]

Hurme M, Kivimäki M, Pertovaara M, Lehtimäki T, Karhunen PJ, Jylhä M, Hervonen A, Eklund C. CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians. Mech Ageing Dev. 2007 Oct;128(10):574-6. Epub 2007 Jul

Hurme M, Korkki S, Lehtimäki T, Karhunen PJ, Jylhä M, Hervonen A, Pertovaara M. Autoimmunity and longevity: Presence of antinuclear antibodies is not associated with the rate of inflammation or mortality in nonagenarians. Mech Ageing Dev 128:407-408, 2007

Jylhä M, Paavilainen P, Lehtimäki T, Goebeler S, Karhunen PJ, Hervonen A, Hurme M: Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: The Vitality 90+ Study. J Gerontol Med Sci 62A(9): 1016-1021, 2007

Goebeler S, Jylhä M, Hervonen A. Self-reported medical history and self-rated health at age 90. Agreement with medical records. Aging Clinical Exp Res 19:213-219, 2007

Lehtimaki T, Hervonen A, Rontu R, Karhunen P, Jylha M, Hurme M. Survival related to plasma C-reactive protein in nonagenarians in modified by apolipropotein E genotype. Clin Chem 53(2): 365-7, 2007

Pertovaara M., Raitala A., Lehtimäki T., Karhunen PJ., Oja SS., Jylhä M., Hervonen A. and Hurme M.: Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev. 127(5); 497-9, 2006

Rontu R., Ojala P., Hervonen A., Goebeler S., Karhunen PJ., Nikkilä M., Kunnas T., Jylhä M., Eklund C., Hurme M. and Lehtimäki T.: Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians. Clin Endocrinol (Oxf.) 64(3); 265-70, 2006

Lehtimäki T., Ojala P., Rontu R., Goebeler S., Karhunen PJ., Jylhä M., Mattila K., Metso S., Jokela H., NIkkilä M., Wuolijoki E., Hervonen A. and Hurme M.: Interleukin-6 modulates plasma cholesterol and c-reactive protein concentrations in nonagenarians. J Am Geriatr Soc. 53(9); 1552-1558, 2005

Hurme M., Paavilainen PM., Pertovaara M., Jylhä M., Karhunen PJ., Hervonen A. and Lehtimäki T.: IgA levels are predictors of mortality in Finnish nonagenarians. Mech Ageing Dev. 126(6-7); 829-31, 2005

Hurme M., Lehtimäki T., Jylhä M., Karhunen PJ. and Hervonen A.: Interleukin-6 - 17G/C polymorphism and longevity: a follow-up study.  Mech Ageing Dev. 126(3); 417-418, 2005

Palkeinen H.:  ”Tässä on kaikki parasta, nyt kun mä elän yksin.” Yksin
olemisen hyvät puolet iäkkäiden naimattomien naisten puheessa. Naistutkimus – Kvinnoforskning 18(1): 30-41, 2005

Saarela MS., Lehtimäki T., Rinne JO., Hervonen A., Jylhä M., Roytta M., Ahonen JP. and Mattila KM. Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increase the risk of Alzheimer's disease in Finns. Neurosci Lett. 367(3); 336-9, 2004

Goebeler S, Jylhä M and Hervonen A.: Use of hospitals at age 90. A population-based study. Arch Gerontol Geriatr 39(1): 93-102, 2004.

Goebeler S, Jylhä M and Hervonen A.: Medical history, cognitive status and mobility at the age of 90. A population-based study in Tampere, Finland. Aging Clinical and Experimental Research 15(2):154-161, 2003.

Niemi AK, Hervonen A, Hurme M, Karhunen PJ, Jylhä M, Majamaa K: Mitochondrial DNA polymorphism associated with longevity in a Finnish population. Human Genetics 112(1): 29-33, 2003.

Wang X-Y, Hurme M, Jylhä M, Hervonen A: Lack of association between human longevity and polymorphism of IL-1 -cluster, IL-6, IL-10 and TNF- alpha genes in Finnish nonagenarians. Mechanisms of Ageing and Development 123(1):29-38, 2001

Lumme-Sandt K, Jylhä M, Hervonen A: Interpretative repertoires of medication among the oldest-old. Social Science & Medicine 50, 1843-1850, 2000

Jolanki O, Jylhä M, Hervonen A: Old age as a necessity and as a free choice. Age talk in the life story interviews with nonagenarians. Journal of Aging Studies 14, 359-372, 2000

Jylhä M, Hervonen A: Functional status and need of help among people aged 90 or over: a mailed survey with a total home-dwelling population. Scand J Public Health 2: 106-111, 1999

Juurinen P, Hervonen A, Jylhä M: Kapina lapsen silmin. Kansalaissota vanhoista vanhimpien elämäkerroissa. Gerontologia 12(3): 119-125, 1998

Jylhä M, Pirttiniemi E, Hervonen A: Vanhoista vanhimmat - tutkimuksen uusi haaste. Tervaskanto 90+ tutkimuksen peruskartoitus. Gerontologia 11(1): 43-52, 1997 (In Finnish: The oldest-old: a new challence to aging research)


Muutettu: 19.4.2016 9.05 Muokkaa

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