IBT julkaisut 2002
NOTE: This list is not exhaustive because it has been collected by an automatic procedure from PubMed. It may also contain publications not related to IMT or Regea authors (authors having the same name). The same publication may also appear more than once in case several research groups have participated in the writing. |
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Bioinformatics Mauno Vihinen - Bioinformatics Group |
| Lappalainen I, Vihinen M Structural basis of ICF-causing mutations in the methyltransferase domain of DNMT3B. Protein Eng 2002 ;15(12)1005-14 PMID |
| Riikonen P, Boberg J, Salakoski T, Vihinen M Mobile access to biological databases on the Internet. IEEE Trans Biomed Eng 2002 ;49(12)1477-9 PMID |
| Okoh MP, Kainulainen L, Heiskanen K, Isa MN, Varming K, Ruuskanen O, Vihinen M Novel insertions of Bruton tyrosine kinase in patients with X-linked agammaglobulinemia. Hum Mutat 2002 ;20(6)480-1 PMID |
| Hyytinen ER, Haapala K, Thompson J, Lappalainen I, Roiha M, Rantala I, Helin HJ, Jänne OA, Vihinen M, Palvimo JJ, Koivisto PA Pattern of somatic androgen receptor gene mutations in patients with hormone-refractory prostate cancer. Lab Invest 2002 ;82(11)1591-8 PMID |
| Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. Haematologica 2002 ;87(6)569-77 PMID |
| Ollila J, Vihinen M Microarray analysis of B-cell stimulation. Vitam Horm 2002 ;6477-99 PMID |
| Okoh MP, Vihinen M Interaction between Btk TH and SH3 domain. Biopolymers 2002 ;63(5)325-34 PMID |
| Väliaho J, Pusa M, Ylinen T, Vihinen M IDR: the ImmunoDeficiency Resource. Nucleic Acids Res 2002 ;30(1)232-4 PMID |
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Biotechnology Vesa Hytönen - Protein Dynamics Markku Kulomaa - Molecular Biotechnology |
| Laitinen OH, Hytönen VP, Ahlroth MK, Pentikäinen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin. Biochem J 2002 ;363(Pt 3)609-17 PMID |
| Wang H, Marjomäki V, Ovod V, Kulomaa MS Subcellular localization of pentachlorophenol 4-monooxygenase in Sphingobium chlorophenolicum ATCC 39723. Biochem Biophys Res Commun 2002 ;299(5)703-9 PMID |
| Tiirola M, Valtonen ET, Rintamäki-Kinnunen P, Kulomaa MS Diagnosis of flavobacteriosis by direct amplification of rRNA genes. Dis Aquat Organ 2002 ;51(2)93-100 PMID |
| Tiirola MA, Wang H, Paulin L, Kulomaa MS Evidence for natural horizontal transfer of the pcpB gene in the evolution of polychlorophenol-degrading sphingomonads. Appl Environ Microbiol 2002 ;68(9)4495-501 PMID |
| Laitinen OH, Hytönen VP, Ahlroth MK, Pentikäinen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin. Biochem J 2002 ;363(Pt 3)609-17 PMID |
| Karisola P, Alenius H, Mikkola J, Kalkkinen N, Helin J, Pentikäinen OT, Repo S, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy. J Biol Chem 2002 ;277(25)22656-61 PMID |
| Tiirola MA, Männistö MK, Puhakka JA, Kulomaa MS Isolation and characterization of Novosphingobium sp. strain MT1, a dominant polychlorophenol-degrading strain in a groundwater bioremediation system. Appl Environ Microbiol 2002 ;68(1)173-80 PMID |
| Lehtolainen P, Taskinen A, Laukkanen J, Airenne KJ, Heino S, Lappalainen M, Ojala K, Marjomäki V, Martin JF, Kulomaa MS, Ylä-Herttuala S Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules. J Biol Chem 2002 ;277(10)8545-50 PMID |
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Cancer Groups Jorma Isola - Cancer Biology Anne Kallioniemi - Cancer Genomics Tapio Visakorpi - Molecular Biology of Prostate Cancer Johanna Schleutker - Genetic Predisposition to Cancer |
| Korsching E, Packeisen J, Agelopoulos K, Eisenacher M, Voss R, Isola J, van Diest PJ, Brandt B, Boecker W, Buerger H Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest 2002 ;82(11)1525-33 PMID |
| Gancberg D, Järvinen T, di Leo A, Rouas G, Cardoso F, Paesmans M, Verhest A, Piccart MJ, Isola J, Larsimont D Evaluation of HER-2/NEU protein expression in breast cancer by immunohistochemistry: an interlaboratory study assessing the reproducibility of HER-2/NEU testing. Breast Cancer Res Treat 2002 ;74(2)113-20 PMID |
| Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. Cancer Res 2002 ;62(16)4554-7 PMID |
| Karhu R, Vilpo L, Isola J, Knuutila S, Vilpo J Cryopreserved chronic lymphocytic leukemia cells analyzed by multicolor fluorescence in situ hybridization after optimized mitogen stimulation. Genes Chromosomes Cancer 2002 ;34(3)345-8 PMID |
| Kytölä S, Nord B, Elder EE, Carling T, Kjellman M, Cedermark B, Juhlin C, Höög A, Isola J, Larsson C Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas. Genes Chromosomes Cancer 2002 ;34(3)325-32 PMID |
| Di Leo A, Gancberg D, Larsimont D, Tanner M, Jarvinen T, Rouas G, Dolci S, Leroy JY, Paesmans M, Isola J, Piccart MJ HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res 2002 ;8(5)1107-16 PMID |
| Paunu N, Pukkala E, Laippala P, Sankila R, Isola J, Miettinen H, Simola KO, Helén P, Helin H, Haapasalo H Cancer incidence in families with multiple glioma patients. Int J Cancer 2002 ;97(6)819-22 PMID |
| Ristimäki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, Joensuu H, Isola J Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 2002 ;62(3)632-5 PMID |
| Savinainen KJ, Saramäki OR, Linja MJ, Bratt O, Tammela TL, Isola JJ, Visakorpi T Expression and gene copy number analysis of ERBB2 oncogene in prostate cancer. Am J Pathol 2002 ;160(1)339-45 PMID |
| Akervall J, Borg A, Dictor M, Jin C, Jin Y, Tanner M, Isola J, Mertens F, Wennerberg J Chromosomal translocations involving 11q13 contribute to cyclin D1 overexpression in squamous cell carcinoma of the head and neck. Int J Oncol 2002 ;20(1)45-52 PMID |
| Kallioniemi A Molecular signatures of breast cancer--predicting the future. N Engl J Med 2002 ;347(25)2067-8 PMID |
| Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringnér M, Sauter G, Monni O, Elkahloun A, Kallioniemi OP, Kallioniemi A Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res 2002 ;62(21)6240-5 PMID |
| Mahlamäki EH, Bärlund M, Tanner M, Gorunova L, Höglund M, Karhu R, Kallioniemi A Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer. Genes Chromosomes Cancer 2002 ;35(4)353-8 PMID |
| Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Genes Chromosomes Cancer 2002 ;35(4)311-7 PMID |
| Andersen CL, Monni O, Wagner U, Kononen J, Bärlund M, Bucher C, Haas P, Nocito A, Bissig H, Sauter G, Kallioniemi A High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays. Am J Pathol 2002 ;161(1)73-9 PMID |
| Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ, Appella E Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002 ;31(2)210-5 PMID |
| Varis A, Wolf M, Monni O, Vakkari ML, Kokkola A, Moskaluk C, Frierson H, Powell SM, Knuutila S, Kallioniemi A, El-Rifai W Targets of gene amplification and overexpression at 17q in gastric cancer. Cancer Res 2002 ;62(9)2625-9 PMID |
| Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A New insights into testicular germ cell tumorigenesis from gene expression profiling. Cancer Res 2002 ;62(8)2359-64 PMID |
| Mousses S, Kallioniemi A, Kauraniemi P, Elkahloun A, Kallioniemi OP Clinical and functional target validation using tissue and cell microarrays. Curr Opin Chem Biol 2002 ;6(1)97-101 PMID |
| Porkka KP, Helenius MA, Visakorpi T Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. Lab Invest 2002 ;82(11)1573-82 PMID |
| Laitinen S, Karhu R, Sawyers CL, Vessella RL, Visakorpi T Chromosomal aberrations in prostate cancer xenografts detected by comparative genomic hybridization. Genes Chromosomes Cancer 2002 ;35(1)66-73 PMID |
| Schulz WA, Elo JP, Florl AR, Pennanen S, Santourlidis S, Engers R, Buchardt M, Seifert HH, Visakorpi T Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer 2002 ;35(1)58-65 PMID |
| Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. Cancer Res 2002 ;62(16)4554-7 PMID |
| Joki-Erkkilä MM, Karikoski R, Rantala I, Lenko HL, Visakorpi T, Heinonen PK Gonadoblastoma and dysgerminoma associated with XY gonadal dysgenesis in an adolescent with chronic renal failure: a case of Frasier syndrome. J Pediatr Adolesc Gynecol 2002 ;15(3)145-9 PMID |
| Porkka K, Saramäki O, Tanner M, Visakorpi T Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. Lab Invest 2002 ;82(5)629-37 PMID |
| Leube B, Drechsler M, Mühlmann K, Schäfer R, Schulz WA, Santourlidis S, Anastasiadis A, Ackermann R, Visakorpi T, Müller W, Royer-Pokora B Refined mapping of allele loss at chromosome 10q23-26 in prostate cancer. Prostate 2002 ;50(3)135-44 PMID |
| Savinainen KJ, Saramäki OR, Linja MJ, Bratt O, Tammela TL, Isola JJ, Visakorpi T Expression and gene copy number analysis of ERBB2 oncogene in prostate cancer. Am J Pathol 2002 ;160(1)339-45 PMID |
| Mononen N, Ikonen T, Autio V, Rökman A, Matikainen MP, Tammela TL, Kallioniemi OP, Koivisto PA, Schleutker J Androgen receptor CAG polymorphism and prostate cancer risk. Hum Genet 2002 ;111(2)166-71 PMID |
| Rökman A, Ikonen T, Seppälä EH, Nupponen N, Autio V, Mononen N, Bailey-Wilson J, Trent J, Carpten J, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Schleutker J Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. Am J Hum Genet 2002 ;70(5)1299-304 PMID |
| Stephan DA, Howell GR, Teslovich TM, Coffey AJ, Smith L, Bailey-Wilson JE, Malechek L, Gildea D, Smith JR, Gillanders EM, Schleutker J, Hu P, Steingruber HE, Dhami P, Robbins CM, Makalowska I, Carpten JD, Sood R, Mumm S, Reinbold R, Bonner TI, Baffoe-Bonnie A, Bubendorf L, Heiskanen M, Kallioneimi OP, Baxevanis AD, Joseph SS, Zucchi I, Burk RD, Isaacs W, Ross MT, Trent JM Physical and transcript map of the hereditary prostate cancer region at xq27. Genomics 2002 ;79(1)41-50 PMID |
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Cellular Biology Ari-Pekka Huovila - Cell Interactions Herma Renkema - Biochemistry of Cell Signaling |
| Renkema GH, Pulkkinen K, Saksela K Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Mol Cell Biol 2002 ;22(19)6719-25 PMID |
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Mitochondrial Genetics Howy Jacobs - Mitochondrial Gene Expression and Disease Group Hans Spelbrink - Molecular Biology-Mitochondrial DNA maintenance |
| Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT, Holt IJ Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell 2002 ;111(4)495-505 PMID |
| Toompuu M, Yasukawa T, Suzuki T, Hakkinen T, Spelbrink JN, Watanabe K, Jacobs HT The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover. J Biol Chem 2002 ;277(25)22240-50 PMID |
| Kajander OA, Karhunen PJ, Jacobs HT The relationship between somatic mtDNA rearrangements, human heart disease and aging. Hum Mol Genet 2002 ;11(3)317-24 PMID |
| Toompuu M, Yasukawa T, Suzuki T, Hakkinen T, Spelbrink JN, Watanabe K, Jacobs HT The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover. J Biol Chem 2002 ;277(25)22240-50 PMID |
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Molecular Immunology Mika Rämet - Experimental Immunology Olli Silvennoinen - Molecular Immunology |
| Lahti M, Lofgren J, Marttila R, Renko M, Klaavuniemi T, Haataja R, Ramet M, Hallman M Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 2002 ;51(6)696-9 PMID |
| Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002 ;416(6881)644-8 PMID |
| Löfgren J, Rämet M, Renko M, Marttila R, Hallman M Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis 2002 ;185(3)283-9 PMID |
| Rämet M, Lanot R, Zachary D, Manfruelli P JNK signaling pathway is required for efficient wound healing in Drosophila. Dev Biol 2002 ;241(1)145-56 PMID |
| Mäkelä T, Silvennoinen O [Year 2002 Anders Jahre Young Scientist Award to Kalle Saksela]. Duodecim 2002 ;118(21)2161-2 PMID |
| Saharinen P, Silvennoinen O The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002 ;277(49)47954-63 PMID |
| Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J 2002 ;21(18)4950-8 PMID |
| Pesu M, Aittomäki S, Takaluoma K, Lagerstedt A, Silvennoinen O p38 Mitogen-activated protein kinase regulates interleukin-4-induced gene expression by stimulating STAT6-mediated transcription. J Biol Chem 2002 ;277(41)38254-61 PMID |
| Olsen H, Hedengran Faulds MA, Saharinen P, Silvennoinen O, Haldosén LA Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem Biophys Res Commun 2002 ;296(1)139-44 PMID |
| Aittomäki S, Yang J, Scott EW, Simon MC, Silvennoinen O Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter. Blood 2002 ;100(3)1078-80 PMID |
| Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol 2002 ;22(10)3316-26 PMID |
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