IBT julkaisut 2004
NOTE: This list is not exhaustive because it has been collected by an automatic procedure from PubMed. It may also contain publications not related to IMT or Regea authors (authors having the same name). The same publication may also appear more than once in case several research groups have participated in the writing. |
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Bioinformatics Mauno Vihinen - Bioinformatics Group |
| Ahola V, Aittokallio T, Uusipaikka E, Vihinen M Statistical methods for identifying conserved residues in multiple sequence alignment. Stat Appl Genet Mol Biol 2004 ;3Article28 PMID |
| Giurcăneanu CD, Tăbuş I, Astola J, Ollila J, Vihinen M Fast iterative gene clustering based on information theoretic criteria for selecting the cluster structure. J Comput Biol 2004 ;11(4)660-82 PMID |
| Ferrer A, Ollila J, Tobin G, Nagy B, Thunberg U, Aalto Y, Vihinen M, Vilpo J, Rosenquist R, Knuutila S Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia. Cancer Genet Cytogenet 2004 ;153(1)69-72 PMID |
| Shen B, Vihinen M Conservation and covariance in PH domain sequences: physicochemical profile and information theoretical analysis of XLA-causing mutations in the Btk PH domain. Protein Eng Des Sel 2004 ;17(3)267-76 PMID |
| Poussu E, Vihinen M, Paulin L, Savilahti H Probing the alpha-complementing domain of E. coli beta-galactosidase with use of an insertional pentapeptide mutagenesis strategy based on Mu in vitro DNA transposition. Proteins 2004 ;54(4)681-92 PMID |
| Samarghitean C, Väliaho J, Vihinen M Online registry of genetic and clinical immunodeficiency diagnostic laboratories, IDdiagnostics. J Clin Immunol 2004 ;24(1)53-61 PMID |
| Vitikainen M, Lappalainen I, Seppala R, Antelmann H, Boer H, Taira S, Savilahti H, Hecker M, Vihinen M, Sarvas M, Kontinen VP Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis. J Biol Chem 2004 ;279(18)19302-14 PMID |
| Halonen M, Kangas H, Rüppell T, Ilmarinen T, Ollila J, Kolmer M, Vihinen M, Palvimo J, Saarela J, Ulmanen I, Eskelin P APECED-causing mutations in AIRE reveal the functional domains of the protein. Hum Mutat 2004 ;23(3)245-57 PMID |
| Lehtonen J, Shen B, Vihinen M, Casini A, Scozzafava A, Supuran CT, Parkkila AK, Saarnio J, Kivelä AJ, Waheed A, Sly WS, Parkkila S Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J Biol Chem 2004 ;279(4)2719-27 PMID |
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Biotechnology Vesa Hytönen - Protein Dynamics Markku Kulomaa - Molecular Biotechnology |
| Hytönen VP, Laitinen OH, Airenne TT, Kidron H, Meltola NJ, Porkka EJ, Hörhä J, Paldanius T, Määttä JA, Nordlund HR, Johnson MS, Salminen TA, Airenne KJ, Ylä-Herttuala S, Kulomaa MS Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli. Biochem J 2004 ;384(Pt 2)385-90 PMID |
| Nordlund HR, Laitinen OH, Hytönen VP, Uotila ST, Porkka E, Kulomaa MS Construction of a dual chain pseudotetrameric chicken avidin by combining two circularly permuted avidins. J Biol Chem 2004 ;279(35)36715-9 PMID |
| Räty JK, Airenne KJ, Marttila AT, Marjomäki V, Hytönen VP, Lehtolainen P, Laitinen OH, Mähönen AJ, Kulomaa MS, Ylä-Herttuala S Enhanced gene delivery by avidin-displaying baculovirus. Mol Ther 2004 ;9(2)282-91 PMID |
| Hytönen VP, Nyholm TK, Pentikäinen OT, Vaarno J, Porkka EJ, Nordlund HR, Johnson MS, Slotte JP, Laitinen OH, Kulomaa MS Chicken avidin-related protein 4/5 shows superior thermal stability when compared with avidin while retaining high affinity to biotin. J Biol Chem 2004 ;279(10)9337-43 PMID |
| Hytönen VP, Laitinen OH, Airenne TT, Kidron H, Meltola NJ, Porkka EJ, Hörhä J, Paldanius T, Määttä JA, Nordlund HR, Johnson MS, Salminen TA, Airenne KJ, Ylä-Herttuala S, Kulomaa MS Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli. Biochem J 2004 ;384(Pt 2)385-90 PMID |
| Nordlund HR, Laitinen OH, Hytönen VP, Uotila ST, Porkka E, Kulomaa MS Construction of a dual chain pseudotetrameric chicken avidin by combining two circularly permuted avidins. J Biol Chem 2004 ;279(35)36715-9 PMID |
| Karisola P, Mikkola J, Kalkkinen N, Airenne KJ, Laitinen OH, Repo S, Pentikäinen OT, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS, Alenius H Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes. J Immunol 2004 ;172(4)2621-8 PMID |
| Räty JK, Airenne KJ, Marttila AT, Marjomäki V, Hytönen VP, Lehtolainen P, Laitinen OH, Mähönen AJ, Kulomaa MS, Ylä-Herttuala S Enhanced gene delivery by avidin-displaying baculovirus. Mol Ther 2004 ;9(2)282-91 PMID |
| Hytönen VP, Nyholm TK, Pentikäinen OT, Vaarno J, Porkka EJ, Nordlund HR, Johnson MS, Slotte JP, Laitinen OH, Kulomaa MS Chicken avidin-related protein 4/5 shows superior thermal stability when compared with avidin while retaining high affinity to biotin. J Biol Chem 2004 ;279(10)9337-43 PMID |
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Cancer Groups Jorma Isola - Cancer Biology Anne Kallioniemi - Cancer Genomics Tapio Visakorpi - Molecular Biology of Prostate Cancer Johanna Schleutker - Genetic Predisposition to Cancer |
| Tanner M, Kapanen AI, Junttila T, Raheem O, Grenman S, Elo J, Elenius K, Isola J Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer. Mol Cancer Ther 2004 ;3(12)1585-92 PMID |
| Lundin J, Lundin M, Isola J, Joensuu H Validation of a Web-based prognostic system for breast cancer. Stud Health Technol Inform 2004 ;107(Pt 1)237-40 PMID |
| Joensuu H, Lehtimäki T, Holli K, Elomaa L, Turpeenniemi-Hujanen T, Kataja V, Anttila A, Lundin M, Isola J, Lundin J Risk for distant recurrence of breast cancer detected by mammography screening or other methods. JAMA 2004 ;292(9)1064-73 PMID |
| Isola J, Tanner M, Forsyth A, Cooke TG, Watters AD, Bartlett JM Interlaboratory comparison of HER-2 oncogene amplification as detected by chromogenic and fluorescence in situ hybridization. Clin Cancer Res 2004 ;10(14)4793-8 PMID |
| Buerger H, Packeisen J, Boecker A, Tidow N, Kersting C, Bielawski K, Isola J, Yatabe Y, Nakachi K, Boecker W, Brandt B Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study. J Pathol 2004 ;203(1)545-50 PMID |
| Isola J, Tanner M Chromogenic in situ hybridization in tumor pathology. Methods Mol Med 2004 ;97133-44 PMID |
| Raitanen M, Worsham MJ, Lakkala T, Carey TE, Van Dyke DL, Grénman R, Klemi P, Rantanen V, Isola J, Grénman S Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry. Gynecol Oncol 2004 ;93(1)155-63 PMID |
| Lassus H, Leminen A, Vayrynen A, Cheng G, Gustafsson JA, Isola J, Butzow R ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma. Gynecol Oncol 2004 ;92(1)31-9 PMID |
| Lehtonen R, Kiuru M, Vanharanta S, Sjöberg J, Aaltonen LM, Aittomäki K, Arola J, Butzow R, Eng C, Husgafvel-Pursiainen K, Isola J, Järvinen H, Koivisto P, Mecklin JP, Peltomäki P, Salovaara R, Wasenius VM, Karhu A, Launonen V, Nupponen NN, Aaltonen LA Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol 2004 ;164(1)17-22 PMID |
| Bärlund M, Kuukasjärvi T, Syrjäkoski K, Auvinen A, Kallioniemi A Frequent amplification and overexpression of CCND1 in male breast cancer. Int J Cancer 2004 ;111(6)968-71 PMID |
| Kauraniemi P, Hautaniemi S, Autio R, Astola J, Monni O, Elkahloun A, Kallioniemi A Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines. Oncogene 2004 ;23(4)1010-3 PMID |
| Linja MJ, Visakorpi T Alterations of androgen receptor in prostate cancer. J Steroid Biochem Mol Biol 2004 ;92(4)255-64 PMID |
| Vleugel MM, Bos R, Buerger H, van der Groep P, Saramäki OR, Visakorpi T, van der Wall E, van Diest PJ No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study. Cell Oncol 2004 ;26(5-6)347-51 PMID |
| Porkka KP, Visakorpi T Molecular mechanisms of prostate cancer. Eur Urol 2004 ;45(6)683-91 PMID |
| Wang R, Xu J, Saramäki O, Visakorpi T, Sutherland WM, Zhou J, Sen B, Lim SD, Mabjeesh N, Amin M, Dong JT, Petros JA, Nelson PS, Marshall FF, Zhau HE, Chung LW PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer. Cancer Res 2004 ;64(5)1589-94 PMID |
| Linja MJ, Porkka KP, Kang Z, Savinainen KJ, Jänne OA, Tammela TL, Vessella RL, Palvimo JJ, Visakorpi T Expression of androgen receptor coregulators in prostate cancer. Clin Cancer Res 2004 ;10(3)1032-40 PMID |
| Nupponen NN, Wallén MJ, Ponciano D, Robbins CM, Tammela TL, Vessella RL, Carpten JD, Visakorpi T Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer. Genes Chromosomes Cancer 2004 ;39(2)119-25 PMID |
| Porkka KP, Tammela TL, Vessella RL, Visakorpi T RAD21 and KIAA0196 at 8q24 are amplified and overexpressed in prostate cancer. Genes Chromosomes Cancer 2004 ;39(1)1-10 PMID |
| Gillanders EM, Xu J, Chang BL, Lange EM, Wiklund F, Bailey-Wilson JE, Baffoe-Bonnie A, Jones M, Gildea D, Riedesel E, Albertus J, Isaacs SD, Wiley KE, Mohai CE, Matikainen MP, Tammela TL, Zheng SL, Brown WM, Rökman A, Carpten JD, Meyers DA, Walsh PC, Schleutker J, Gronberg H, Cooney KA, Isaacs WB, Trent JM Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst 2004 ;96(16)1240-7 PMID |
| Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa DO, Tuzmen S, Weaver D, Robbins C, Moses T, Allinen M, Hautaniemi S, Chen Y, Elkahloun A, Basik M, Bova GS, Bubendorf L, Lugli A, Sauter G, Schleutker J, Ozcelik H, Elowe S, Pawson T, Trent JM, Carpten JD, Kallioniemi OP, Mousses S Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet 2004 ;36(9)979-83 PMID |
| Koivisto PA, Hyytinen ER, Matikainen M, Tammela TL, Ikonen T, Schleutker J Kruppel-like factor 6 germ-line mutations are infrequent in Finnish hereditary prostate cancer. J Urol 2004 ;172(2)506-7 PMID |
| Koivisto PA, Hyytinen ER, Matikainen M, Tammela TL, Ikonen T, Schleutker J Germline mutation analysis of the androgen receptor gene in Finnish patients with prostate cancer. J Urol 2004 ;171(1)431-3 PMID |
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Cellular Biology Ari-Pekka Huovila - Cell Interactions Herma Renkema - Biochemistry of Cell Signaling |
| Ortiz RM, Kärkkäinen I, Huovila AP Aberrant alternative exon use and increased copy number of human metalloprotease-disintegrin ADAM15 gene in breast cancer cells. Genes Chromosomes Cancer 2004 ;41(4)366-78 PMID |
| Pulkkinen K, Renkema GH, Kirchhoff F, Saksela K Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. J Virol 2004 ;78(23)12773-80 PMID |
| Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Müller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Münch J Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol 2004 ;78(13)6864-74 PMID |
| Alfthan K, Heiska L, Grönholm M, Renkema GH, Carpén O Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem 2004 ;279(18)18559-66 PMID |
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Mitochondrial Genetics Howy Jacobs - Mitochondrial Gene Expression and Disease Group Hans Spelbrink - Molecular Biology-Mitochondrial DNA maintenance |
| Jacobs HT, Fernández-Ayala DJ, Manjiry S, Kemppainen E, Toivonen JM, O'Dell KM Mitochondrial disease in flies. Biochim Biophys Acta 2004 ;1659(2-3)190-6 PMID |
| Smeitink JA, Jacobs HT The Euromit meetings: an international platform for the understanding and combat of mitochondrial disease. Biochim Biophys Acta 2004 ;1659(2-3)105-6 PMID |
| Andrés AM, Soldevila M, Lao O, Volpini V, Saitou N, Jacobs HT, Hayasaka I, Calafell F, Bertranpetit J Comparative genetics of functional trinucleotide tandem repeats in humans and apes. J Mol Evol 2004 ;59(3)329-39 PMID |
| Toompuu M, Levinger LL, Nadal A, Gomez J, Jacobs HT The 7472insC mtDNA mutation impairs 5' and 3' processing of tRNA(Ser(UCN)). Biochem Biophys Res Commun 2004 ;322(3)803-13 PMID |
| Rovio AT, Abel J, Ahola AL, Andres AM, Bertranpetit J, Blancher A, Bontrop RE, Chemnick LG, Cooke HJ, Cummins JM, Davis HA, Elliott DJ, Fritsche E, Hargreave TB, Hoffman SM, Jequier AM, Kao SH, Kim HS, Marchington DR, Mehmet D, Otting N, Poulton J, Ryder OA, Schuppe HC, Takenaka O, Wei YH, Wichmann L, Jacobs HT A prevalent POLG CAG microsatellite length allele in humans and African great apes. Mamm Genome 2004 ;15(6)492-502 PMID |
| Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004 ;429(6990)417-23 PMID |
| Tyynismaa H, Sembongi H, Bokori-Brown M, Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ, Suomalainen A Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet 2004 ;13(24)3219-27 PMID |
| Wanrooij S, Luoma P, van Goethem G, van Broeckhoven C, Suomalainen A, Spelbrink JN Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA. Nucleic Acids Res 2004 ;32(10)3053-64 PMID |
| Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004 ;429(6990)417-23 PMID |
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Molecular Immunology Mika Rämet - Experimental Immunology Olli Silvennoinen - Molecular Immunology |
| Rämet M [Innate immunity and infections in children]. Duodecim 2004 ;120(5)553-60 PMID |
| Yamaoka K, Saharinen P, Pesu M, Holt VE, Silvennoinen O, O'Shea JJ The Janus kinases (Jaks). Genome Biol 2004 ;5(12)253 PMID |
| Paukku K, Silvennoinen O STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev 2004 ;15(6)435-55 PMID |
| Peltola KJ, Paukku K, Aho TL, Ruuska M, Silvennoinen O, Koskinen PJ Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3. Blood 2004 ;103(10)3744-50 PMID |
| Aittomäki S, Yang J, Scott EW, Simon MC, Silvennoinen O Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fcgamma receptor I promoter activation. Int Immunol 2004 ;16(2)265-74 PMID |
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Regenerative Medicine Katriina Aalto-Setälä - Cardiology Group Susanna Miettinen - Adult Stem Cell Group |
| Erkkilä L, Laitinen K, Haasio K, Tiirola T, Jauhiainen M, Lehr HA, Aalto-Setälä K, Saikku P, Leinonen M Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection. Atherosclerosis 2004 ;177(2)321-8 PMID |
| Vienonen A, Miettinen S, Bläuer M, Martikainen PM, Tomás E, Heinonen PK, Ylikomi T Expression of nuclear receptors and cofactors in human endometrium and myometrium. J Soc Gynecol Investig 2004 ;11(2)104-12 PMID |
| Miettinen S, Ahonen MH, Lou YR, Manninen T, Tuohimaa P, Syvälä H, Ylikomi T Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells. Int J Cancer 2004 ;108(3)367-73 PMID |
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33520 Tampere, Finland
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33520 Tampere, Finland
