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Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences
ISTNET

ISTNET (Developmental) Neurotoxicity

International Stakeholder Network for creating a (Developmental) Neurotoxicity Testing Roadmap

Current animal tests are performing dissatisfactory in predicting hazards for human health. There is  good consensus in both the scientific and regulatory community that  toxicity testing must move from expensive and time-consuming in vivo testing to faster and cheaper alternative testing strategies that will allow screening and priorizitation of large numbers of chemicals. Therefore, new concepts for safety testing which are based on human biology are being developed. This process has been science-driven and has largely failed to deliver validated test methods. We have therefore initiated a NEED-driven process in which we will actively promote and coordinate the development of alternative methods for developmental neurotoxicity (DNT) and adult neurotoxicity (NT) testing followed by their incorporation into the regulatory guidelines (OECD). To achieve this goal, networking between various stakeholders is required in order to establish a NEED-driven road map of DNT and NT test development and validation. Therefore the Neurotoxicologists and Neurobiologists on both sides of the Atlantic created ISNET (International Stakeholder Network for Creating a (Developmental) neurotoxicity Testing Roadmap) that will develop a unique path by performing a holistic approach for DNT/NT spanning from societal needs via technological possibilities to implemented risk assessment. The main focus of  ISTNET  is on bringing together scientists, regulator and industry to define test requirements and to adapt their development and standardization accordingly.

ISTNET Steering Committee:

Timo Ylikomi and Tuula Heinonen

FICAM (Finnish Centre for alternative methods), University of Tampere, Tampere,  Finland

Ellen Fritsche

Leibniz Research Institute for Environmental Medicine Molecular Toxicology, Düsseldorf, Germany

Helena Hogberg

CAAT, Johns Hopkins University, Baltimore, USA

Marcel Leist and Mardas Daneshian

CAAT-EUROPE, Unversity of Konstanz, Konstanz, Germany

Anna Price

EURL-ECVAM, Ispra, Italy

Luc Stoppini

University of Applied Sciences Western Switzerland, HEPIA & SCAHT- Geneva, Switzerland

Florianne Tschudi-Monnet

University of Lausanne and SCAHT, Lausanne, Switzerland

Martin Wilk

Swiss Center for Applied Human Toxicology, University of Basel, Switzerland

Contact:
istnet@uta.fi

 
Maintained by: med.info@uta.fi
Last update: 17.12.2013 13.49 Muokkaa

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