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university of tampere: faculty of medicine and life sciences: research:
Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences

Medical Biochemistry

Professor:
Olli Silvennoinen
tel. +358 (0)50 359 5740
olli.silvennoinen@uta.fi

Molecular Immunology Group - Cytokine signaling in health and disease >>

Associate professor:
Seppo Nikkari
tel. +358 (0)50 396 9639
seppo.nikkari@uta.fi

University lecturers:

Tiina Solakivi
tel. +358 (0)50 318 6356
tiina.solakivi@uta.fi

Tarja Kunnas
tel. +358 (0)50 318 6320
tarja.kunnas@uta.fi


Ongoing research:

Cardiovascular risk factors: The TAMRISK study

We have priority to the Tampere adult population health risk (TAMRISK) material. This has been collected from the year 1980 and it comprises of approx. 400 000 person years of health follow-up, divided to age cohorts. Gene-environment interactions affecting cardiovascular disease incidence are currently under investigation.
The data for the TAMRISK study has been collected from periodic health examinations (PHE) done for 50-year-old men and women living in Tampere, Finland.  TAMRISK data includes information of risk factors for hypertension: blood pressure, weight, family history of cardiovascular diseases, lipid values and smoking, diabetes and exercise habits. Buccal swabs for DNA extraction and a permissions form to use PHE data were collected by mail separately of the physical examination. The DNA samples were collected during years 2006-2010. Informed consent was obtained from all participants. The Ethics Committees of the Tampere University Hospital and the City of Tampere approved the study.

Latest publications:

Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
ACS Med Chem Lett ;8(6)618-621, 2017
PMID

Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
Cell Rep ;19(2)281-294, 2017
PMID

Pertovaara M, Silvennoinen O, Isomäki P
Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome.
Clin Immunol ;2016
PMID

 
Maintained by: med.info@uta.fi
Last update: 16.2.2017 10.23 Muokkaa

University of Tampere
+358 3 355 111
registry@uta.fi


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