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university of tampere: faculty of medicine and life sciences: research:
Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences

Microbiology and Immunology

Professor:
Mikko Hurme, M.D., Ph.D.
tel. +358 50 567 2717
mikko.a.hurme@uta.fi

University lecturer:
Saara Marttila, PhD
tel. +358 50 318 5813
saara.marttila@uta.fi

Researchers/ Doctoral Student:
Laura Kananen, M.Sc.
laura.kananen@uta.fi

Tapio Nevalainen, M.Sc.
tapio.l.nevalainen@uta.fi

Laboratory/office:
Sinikka Repo-Koskinen, technician
tel. +358 40 190 1503
sinikka.repo-koskinen@uta.fi

 

Research projects:

The biological effects of human aging (regulation of gene expression, epigenetics and biomarkers). This research is partly performed in collaboration with two European Union consortia (Genetics of Healthy Aging, GEHA, and Biomarkers of Human Aging, Mark-Age). The research group is also a member of The Gerontology Research Center (GEREC) (University of Tampere and University of Jyväskylä).

Recent publications:

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Shen X, Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB, Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bertram L, Pendleton N, Kardia SLR, Ciullo M, Becker DM, Wong A, Psaty BM, van Duijn CM, Wilson JG, Jukema JW, Kiemeney L, Uitterlinden AG, Franceschini N, North KE, Weir DR, Metspalu A, Boomsma DI, Hayward C, Chasman D, Martin NG, Sattar N, Campbell H, Esko T, Kutalik Z, Wilson JF
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Nat Commun ;8(1)910, 2017
PMID

Marttila S, Nevalainen T, Jylhävä J, Kananen L, Jylhä M, Hervonen A, Hurme M
Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.
Exp Gerontol ;2017
PMID

Koivisto M, Grassini S, Hurme M, Salminen-Vaparanta N, Railo H, Vorobyev V, Tallus J, Paavilainen T, Revonsuo A
TMS-EEG reveals hemispheric asymmetries in top-down influences of posterior intraparietal cortex on behavior and visual event-related potentials.
Neuropsychologia ;2017
PMID

Hurme M, Koivisto M, Revonsuo A, Railo H
Early processing in primary visual cortex is necessary for conscious and unconscious vision while late processing is necessary only for conscious vision in neurologically healthy humans.
Neuroimage ;2017
PMID

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B
Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study.
Exp Gerontol ;2017
PMID

Lisko I, Tiainen K, Raitanen J, Jylhävä J, Hurme M, Hervonen A, Jylhä M, Stenholm S
Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study.
J Gerontol A Biol Sci Med Sci ;72(11)1569-1574, 2017
PMID

Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Li Pira G, Giorda E, Carrozzo R, Bergvall M, Bergström T, Alfredsson L, Olsson T, Kockum I, Seppälä I, Lehtimäki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D
Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.
Cell Rep ;20(4)846-853, 2017
PMID

Nevalainen T, Kananen L, Marttila S, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.
Clin Epigenetics ;2017
PMID

Koivula TT, Tuulasvaara A, Hetemäki I, Hurme M, Mäkelä S, Mustonen J, Vaheri A, Arstila TP
Indoleamine 2,3-dioxygenase activity is associated with regulatory T cell response in acute Puumala hantavirus infection.
Pathog Dis ;2017
PMID

Ådjers K, Luukkainen A, Pekkanen J, Hurme M, Huhtala H, Renkonen R, Wang Y, Mäkelä MJ, Karjalainen J, Toppila-Salmi S
Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
Int Arch Allergy Immunol ;172(2)123-128, 2017
PMID

Nevalainen T, Kananen L, Marttila S, Jylhävä J, Jylhä M, Hervonen A, Hurme M
Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals.
PLoS One ;11(11)e0167028, 2016
PMID

Lehtonen JM, Forsström S, Bottani E, Viscomi C, Baris OR, Isoniemi H, Höckerstedt K, Österlund P, Hurme M, Jylhävä J, Leppä S, Markkula R, Heliö T, Mombelli G, Uusimaa J, Laaksonen R, Laaksovirta H, Auranen M, Zeviani M, Smeitink J, Wiesner RJ, Nakada K, Isohanni P, Suomalainen A
FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders.
Neurology ;87(22)2290-2299, 2016
PMID

Ciccarone F, Malavolta M, Calabrese R, Guastafierro T, Bacalini MG, Reale A, Franceschi C, Capri M, Hervonen A, Hurme M, Grubeck-Loebenstein B, Koller B, Bernhardt J, Schӧn C, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé M, Moreno-Villanueva M, Sindlinger T, Bürkle A, Zampieri M, Caiafa P
Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.
Aging Cell ;15(4)755-65, 2016
PMID

Jylhävä J, Kananen L, Raitanen J, Marttila S, Nevalainen T, Hervonen A, Jylhä M, Hurme M
Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift.
Oncotarget ;7(15)19228-41, 2016
PMID

Enroth L, Raitanen J, Hervonen A, Lehtimäki T, Jylhävä J, Hurme M, Jylhä M
Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years.
J Gerontol A Biol Sci Med Sci ;71(3)412-9, 2016
PMID

Alapirtti T, Jylhävä J, Raitanen J, Mäkinen R, Peltola J, Hurme MA, Liimatainen S
The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy.
Neurol Res ;38(1)45-50, 2016
PMID

 
Maintained by: med.info@uta.fi
Last update: 5.5.2017 13.15 Muokkaa

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