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university of tampere: faculty of medicine and life sciences: research:
Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences


Markku Mäki 
tel. + 358 50 318 6337

Matti Korppi 
tel. +358 50 318 6316

Tampere Center for Child Health Research (TACC) is a scientific unit that was created in 2012 through a restructuring and expansion of activities formerly carried out by several independent actors at the University of Tampere and Tampere University Hospital. TACC carries out multidisciplinary research with a wide range of methodologies, aiming at improved means to promote and resume healthy growth among infants and children worldwide. 

Tampere Center for Child Health Research (TACC) >>


Recent publications (Markku Mäki):

Viitasalo L, Kurppa K, Ashorn M, Saavalainen P, Huhtala H, Ashorn S, Mäki M, Ilus T, Kaukinen K, Iltanen S
Microbial Biomarkers in Patients with Nonresponsive Celiac Disease.
Dig Dis Sci ;63(12)3434-3441, 2018

Pekki H, Kaukinen K, Ilus T, Mäki M, Huhtala H, Laurila K, Kurppa K
Long-term follow-up in adults with coeliac disease: Predictors and effect on health outcomes.
Dig Liver Dis ;50(11)1189-1194, 2018

Ludvigsson JF, Ciacci C, Green PH, Kaukinen K, Korponay-Szabo IR, Kurppa K, Murray JA, Lundin KEA, Maki MJ, Popp A, Reilly NR, Rodriguez-Herrera A, Sanders DS, Schuppan D, Sleet S, Taavela J, Voorhees K, Walker MM, Leffler DA
Outcome measures in coeliac disease trials: the Tampere recommendations.
Gut ;67(8)1410-1424, 2018

Fuchs V, Kurppa K, Huhtala H, Mäki M, Kekkonen L, Kaukinen K
Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: A prospective nationwide study.
United European Gastroenterol J ;6(4)567-575, 2018

Singh P, Arora A, Strand TA, Leffler DA, Mäki M, Kelly CP, Ahuja V, Makharia GK
Diagnostic Accuracy of Point of Care Tests for Diagnosing Celiac Disease: A Systematic Review and Meta-Analysis.
J Clin Gastroenterol ;2018

Laurikka P, Lindfors K, Oittinen M, Huhtala H, Salmi T, Lähdeaho ML, Ilus T, Mäki M, Kaukinen K, Kurppa K
Dietary Factors and Mucosal Immune Response in Celiac Disease Patients Having Persistent Symptoms Despite a Gluten-free Diet.
J Clin Gastroenterol ;2018

Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.
Am J Gastroenterol ;113(3)339-347, 2018

Maki M, Mearin ML, Polanco I, Schmitz J, Troncone R
Chapter 5.1.1. Coeliac Disease.
J Pediatr Gastroenterol Nutr ;2018

Yohannes DA, Freitag TL, de Kauwe A, Kaukinen K, Kurppa K, Wacklin P, Mäki M, Arstila TP, Anderson RP, Greco D, Saavalainen P
Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease.
Sci Rep ;7(1)17977, 2017

Goel G, King T, Daveson AJ, Andrews JM, Krishnarajah J, Krause R, Brown GJE, Fogel R, Barish CF, Epstein R, Kinney TP, Miner PB, Tye-Din JA, Girardin A, Taavela J, Popp A, Sidney J, Mäki M, Goldstein KE, Griffin PH, Wang S, Dzuris JL, Williams LJ, Sette A, Xavier RJ, Sollid LM, Jabri B, Anderson RP
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.
Lancet Gastroenterol Hepatol ;2(7)479-493, 2017

Aaltonen K, Laurikka P, Huhtala H, Mäki M, Kaukinen K, Kurppa K
The Long-Term Consumption of Oats in Celiac Disease Patients Is Safe: A Large Cross-Sectional Study.
Nutrients ;2017

Kalliokoski S, Piqueras VO, Frías R, Sulic AM, Määttä JA, Kähkönen N, Viiri K, Huhtala H, Pasternack A, Laurila K, Sblattero D, Korponay-Szabó IR, Mäki M, Caja S, Kaukinen K, Lindfors K
Transglutaminase 2-specific coeliac disease autoantibodies induce morphological changes and signs of inflammation in the small-bowel mucosa of mice.
Amino Acids ;49(3)529-540, 2017

Oittinen M, Popp A, Kurppa K, Lindfors K, Mäki M, Kaikkonen MU, Viiri K
Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia.
Stem Cells ;35(2)445-457, 2017

Kivelä L, Kaukinen K, Huhtala H, Lähdeaho ML, Mäki M, Kurppa K
At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study.
J Pediatr ;2017

Rajalahti T, Repo M, Kivelä L, Huhtala H, Mäki M, Kaukinen K, Lindfors K, Kurppa K
Anemia in Pediatric Celiac Disease: Association With Clinical and Histological Features and Response to Gluten-free Diet.
J Pediatr Gastroenterol Nutr ;64(1)e1-e6, 2017

Jinga M, Balaban DV, Peride I, Niculae A, DuŢescu IM, Vasilescu F, Mäki M, Popp AM
Crypt hyperplastic enteropathy in distal duodenum in Helicobacter pylori infection - report of two cases without evidence of celiac disease.
Rom J Morphol Embryol ;58(2)685-688, 2017

Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.
Cell Mol Gastroenterol Hepatol ;4(1)1-17, 2017

Pasternack C, Kaukinen K, Kurppa K, Mäki M, Collin P, Hervonen K, Reunala T, Huhtala H, Kekkonen L, Salmi T
Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study.
Acta Derm Venereol ;97(1)58-62, 2017

Repo M, Lindfors K, Mäki M, Huhtala H, Laurila K, Lähdeaho ML, Saavalainen P, Kaukinen K, Kurppa K
Anemia and Iron Deficiency in Children With Potential Celiac Disease.
J Pediatr Gastroenterol Nutr ;64(1)56-62, 2017

Recent publications (Matti Korppi):

Korppi M
Discharge Criteria for Bronchiolitis: Does Age Matter?
Pediatr Infect Dis J ;37(12)e350, 2018

Holster A, Teräsjärvi J, Vuononvirta J, Koponen P, Peltola V, Helminen M, He Q, Korppi M, Nuolivirta K
Polymorphisms in the promoter region of IL10 gene are associated with virus etiology of infant bronchiolitis.
World J Pediatr ;14(6)594-600, 2018

Salmivesi S, Korppi M
The time has come to stop placebo-controlled trials of milk oral immunotherapy and focus on real-life studies.
Acta Paediatr ;107(11)1855-1856, 2018

Palmu S, Mecklin M, Heikkilä P, Backman K, Peltola V, Renko M, Korppi M
National treatment guidelines decreased the use of racemic adrenaline for bronchiolitis in four Finnish university hospitals.
Acta Paediatr ;107(11)1966-1970, 2018

Korppi M
Review shows paediatric protracted bacterial bronchitis needs an accurate diagnosis and strictly targeted extended antibiotics.
Acta Paediatr ;2018

Korppi M, Teräsjärvi J, Vuononvirta J, Liehu-Martiskainen M, Huhtala H, Kröger L, Pöyhönen L, He Q
Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.
Acta Paediatr ;107(12)2217-2218, 2018

Heikkilä P, Sokuri P, Mecklin M, Nuolivirta K, Tapiainen T, Peltoniemi O, Renko M, Korppi M
Using high-flow nasal cannulas for infants with bronchiolitis admitted to paediatric wards is safe and feasible.
Acta Paediatr ;107(11)1971-1976, 2018

Korppi M
Universal pneumococcal vaccination provides marked indirect beneficial effects through herd immunity.
Acta Paediatr ;2018

Korppi M, Nuolivirta K
Exploratory and confirmatory studies have different targets and both are needed in clinical research.
Acta Paediatr ;107(5)734-735, 2018

Pasanen A, Karjalainen MK, Kummola L, Waage J, Bønnelykke K, Ruotsalainen M, Piippo-Savolainen E, Goksör E, Nuolivirta K, Chawes B, Vissing N, Bisgaard H, Jartti T, Wennergren G, Junttila I, Hallman M, Korppi M, Rämet M
NKG2D gene variation and susceptibility to viral bronchiolitis in childhood.
Pediatr Res ;84(3)451-457, 2018

Eskola V, Pohjankoski H, Kröger L, Aalto K, Latva K, Korppi M
Cryopyrin-associated periodic syndrome in early childhood can be successfully treated with interleukin-1 blockades.
Acta Paediatr ;107(4)577-580, 2018

Korppi M, Tapiainen T
High-flow oxygen therapy is safe and effective in infants with bronchiolitis.
Acta Paediatr ;107(8)1306-1307, 2018

Korppi M
Monitoring of respiratory rate poorly predicts outcome of high-flow oxygen therapy.
Pediatr Pulmonol ;53(7)855-856, 2018

Nuolivirta K, Holster A, Teräsjärvi J, Lauhkonen E, Törmänen S, Helminen M, Koponen P, Korppi M, He Q
IL17A gene polymorphisms rs4711998 and rs8193036 are not associated with postbronchiolitis asthma in Finnish children.
Acta Paediatr ;107(7)1290-1291, 2018

Korppi M, Lauhkonen E
Auscultation of respiratory sounds: how to practise, how to teach?
Acta Paediatr ;107(7)1120-1121, 2018

Heikkilä P, Mecklin M, Korppi M
The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis: a decision analysis.
World J Pediatr ;14(1)26-34, 2018

Heikkilä P, Renko M, Korppi M
Hypertonic saline inhalations in bronchiolitis-A cumulative meta-analysis.
Pediatr Pulmonol ;53(2)233-242, 2018

Haataja P, Korhonen P, Ojala R, Hirvonen M, Korppi M, Gissler M, Luukkaala T, Tammela O
Hospital admissions for lower respiratory tract infections in children born moderately/late preterm.
Pediatr Pulmonol ;53(2)209-217, 2018

Salmivesi S, Paassilta M, Huhtala H, Nieminen R, Moilanen E, Korppi M
Elevated serum adipsin may predict unsuccessful treatment for cows' milk allergy but other biomarkers do not.
Acta Paediatr ;107(2)328-332, 2018

Kivistö JE, Protudjer JLP, Karjalainen J, Bergström A, Korppi M
Trends in paediatric asthma hospitalisations - differences between neighbouring countries.
Thorax ;73(2)185-187, 2018

Korppi M
Hypertonic saline: Not useful in infant bronchiolitis?
Pediatr Pulmonol ;53(6)692-693, 2018

Holster A, Teräsjärvi J, Lauhkonen E, Törmänen S, Helminen M, Koponen P, Korppi M, Peltola V, He Q, Nuolivirta K
IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy.
Allergol Int ;67(1)109-113, 2018

Törmänen S, Teräsjärvi J, Lauhkonen E, Helminen M, Koponen P, Korppi M, Nuolivirta K, He Q
TLR5 rs5744174 gene polymorphism is associated with the virus etiology of infant bronchiolitis but not with post-bronchiolitis asthma.
Health Sci Rep ;1(6)e38, 2018

Mecklin M, Heikkilä P, Korppi M
The change in management of bronchiolitis in the intensive care unit between 2000 and 2015.
Eur J Pediatr ;2018

Korppi M
Hypertonic saline in viral wheezing.
Pediatr Pulmonol ;53(5)533-534, 2018

Lauhkonen E, Riikonen R, Törmänen S, Koponen P, Nuolivirta K, Helminen M, Toikka J, Korppi M
Impulse oscillometry at preschool age is a strong predictor of lung function by flow-volume spirometry in adolescence.
Pediatr Pulmonol ;53(5)552-558, 2018

Korhonen P, Haataja P, Ojala R, Hirvonen M, Korppi M, Paassilta M, Uotila J, Gissler M, Luukkaala T, Tammela O
Asthma and atopic dermatitis after early-, late-, and post-term birth.
Pediatr Pulmonol ;53(3)269-277, 2018

Palmu S, Heikkilä P, Uski V, Niitty S, Kurikka S, Korppi M
National allergy programme had little impact on parent-reported food allergies in children aged 6-7 years.
Acta Paediatr ;107(1)121-125, 2018

Törmänen S, Korppi M, Lauhkonen E, Koponen P, Teräsjärvi J, Vuononvirta J, Helminen M, He Q, Nuolivirta K
Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence.
Acta Paediatr ;107(1)134-139, 2018

Mecklin M, Heikkilä P, Korppi M
Low age, low birthweight and congenital heart disease are risk factors for intensive care in infants with bronchiolitis.
Acta Paediatr ;106(12)2004-2010, 2017

Sokuri P, Heikkilä P, Korppi M
National high-flow nasal cannula and bronchiolitis survey highlights need for further research and evidence-based guidelines.
Acta Paediatr ;106(12)1998-2003, 2017

Husby A, Pasanen A, Waage J, Sevelsted A, Hodemaekers H, Janssen R, Karjalainen MK, Stokholm J, Chawes BL, Korppi M, Wennergren G, Heinzmann A, Bont L, Bisgaard H, Bønnelykke K
CDHR3 gene variation and childhood bronchiolitis.
J Allergy Clin Immunol ;140(5)1469-1471.e7, 2017

Liehu-Martiskainen M, Korppi M, Teräsjärvi J, Vuononvirta J, Huhtala H, Nuolivirta K, Kröger L, Peltola V, Pöyhönen L, He Q
Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette-Guérin vaccination.
Acta Paediatr ;106(11)1837-1841, 2017

Törmänen S, Korppi M, Teräsjärvi J, Vuononvirta J, Koponen P, Helminen M, He Q, Nuolivirta K
Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis.
Sci Rep ;7(1)2956, 2017

Korppi M, Teräsjärvi J, Liehu-Martiskainen M, Lauhkonen E, Vuononvirta J, Nuolivirta K, Kröger L, Pöyhönen L, Karjalainen MK, He Q
Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination.
Sci Rep ;7(1)11691, 2017

Elenius V, Bergroth E, Koponen P, Remes S, Piedra PA, Espinola JA, Korppi M, Camargo CA, Jartti T
Marked variability observed in inpatient management of bronchiolitis in three Finnish hospitals.
Acta Paediatr ;106(9)1512-1518, 2017

Korppi M
The role of rhinoviruses is overestimated in the aetiology of community-acquired pneumonia in children.
Acta Paediatr ;106(3)363-365, 2017

Pöyhönen L, Kröger L, Huhtala H, Mäkinen J, Nuolivirta K, Mertsola J, He Q, Korppi M
Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-γ and IL-12 in BCG Osteitis Survivors R1.
Pediatr Infect Dis J ;36(2)135-139, 2017

Pasanen A, Karjalainen MK, Bont L, Piippo-Savolainen E, Ruotsalainen M, Goksör E, Kumawat K, Hodemaekers H, Nuolivirta K, Jartti T, Wennergren G, Hallman M, Rämet M, Korppi M
Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.
Sci Rep ;2017

Korppi M, Nuolivirta K, Lauhkonen E, Holster A, Teräsjärvi J, Vuononvirta J, Helminen M, He Q, Koponen P
IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.
Pediatr Pulmonol ;52(1)14-20, 2017

Teräsjärvi J, Hakanen A, Korppi M, Nuolivirta K, Gröndahl-Yli-Hannuksela K, Mertsola J, Peltola V, He Q
Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis.
Sci Rep ;2017

Nieminen O, Korppi M, Helminen M
Healthcare costs doubled when children had urinary tract infections caused by extended-spectrum β-lactamase-producing bacteria.
Acta Paediatr ;106(2)327-333, 2017

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