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university of tampere: faculty of medicine and life sciences: research:
Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences


Markku Mäki 
tel. + 358 50 318 6337

Matti Korppi 
tel. +358 50 318 6316

Tampere Center for Child Health Research (TACC) is a scientific unit that was created in 2012 through a restructuring and expansion of activities formerly carried out by several independent actors at the University of Tampere and Tampere University Hospital. TACC carries out multidisciplinary research with a wide range of methodologies, aiming at improved means to promote and resume healthy growth among infants and children worldwide. 

Tampere Center for Child Health Research (TACC) >>


Recent publications (Markku Mäki):

Goel G, King T, Daveson AJ, Andrews JM, Krishnarajah J, Krause R, Brown GJE, Fogel R, Barish CF, Epstein R, Kinney TP, Miner PB, Tye-Din JA, Girardin A, Taavela J, Popp A, Sidney J, Mäki M, Goldstein KE, Griffin PH, Wang S, Dzuris JL, Williams LJ, Sette A, Xavier RJ, Sollid LM, Jabri B, Anderson RP
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.
Lancet Gastroenterol Hepatol ;2(7)479-493, 2017

Aaltonen K, Laurikka P, Huhtala H, Mäki M, Kaukinen K, Kurppa K
The Long-Term Consumption of Oats in Celiac Disease Patients Is Safe: A Large Cross-Sectional Study.
Nutrients ;2017

Kivelä L, Kaukinen K, Huhtala H, Lähdeaho ML, Mäki M, Kurppa K
At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study.
J Pediatr ;2017

Kalliokoski S, Piqueras VO, Frías R, Sulic AM, Määttä JA, Kähkönen N, Viiri K, Huhtala H, Pasternack A, Laurila K, Sblattero D, Korponay-Szabó IR, Mäki M, Caja S, Kaukinen K, Lindfors K
Transglutaminase 2-specific coeliac disease autoantibodies induce morphological changes and signs of inflammation in the small-bowel mucosa of mice.
Amino Acids ;49(3)529-540, 2017

Oittinen M, Popp A, Kurppa K, Lindfors K, Mäki M, Kaikkonen MU, Viiri K
Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia.
Stem Cells ;35(2)445-457, 2017

Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.
Cell Mol Gastroenterol Hepatol ;4(1)1-17, 2017

Repo M, Lindfors K, Mäki M, Huhtala H, Laurila K, Lähdeaho ML, Saavalainen P, Kaukinen K, Kurppa K
Anemia and Iron Deficiency in Children With Potential Celiac Disease.
J Pediatr Gastroenterol Nutr ;64(1)56-62, 2017

Rajalahti T, Repo M, Kivelä L, Huhtala H, Mäki M, Kaukinen K, Lindfors K, Kurppa K
Anemia in Pediatric Celiac Disease: Association With Clinical and Histological Features and Response to Gluten-free Diet.
J Pediatr Gastroenterol Nutr ;64(1)e1-e6, 2017

Jinga M, Balaban DV, Peride I, Niculae A, DuŢescu IM, Vasilescu F, Mäki M, Popp AM
Crypt hyperplastic enteropathy in distal duodenum in Helicobacter pylori infection - report of two cases without evidence of celiac disease.
Rom J Morphol Embryol ;58(2)685-688, 2017

Pasternack C, Kaukinen K, Kurppa K, Mäki M, Collin P, Hervonen K, Reunala T, Huhtala H, Kekkonen L, Salmi T
Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study.
Acta Derm Venereol ;97(1)58-62, 2017

Äärelä L, Nurminen S, Kivelä L, Huhtala H, Mäki M, Viitasalo A, Kaukinen K, Lakka T, Kurppa K
Prevalence and associated factors of abnormal liver values in children with celiac disease.
Dig Liver Dis ;48(9)1023-9, 2016

Kylökäs A, Kaukinen K, Huhtala H, Collin P, Mäki M, Kurppa K
Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation.
BMC Gastroenterol ;16(1)76, 2016

Urbonas V, Sadauskaite J, Cerkauskiene R, Kaminskas A, Mäki M, Kurppa K
Population-Based Screening for Selective Immunoglobulin A (IgA) Deficiency in Lithuanian Children Using a Rapid Antibody-Based Fingertip Test.
Med Sci Monit ;2016

Taavela J, Popp A, Kurppa K, Mäki M
Is There a Role for Duodenal Bulb Biopsies in Celiac Disease Diagnostics?
Clin Gastroenterol Hepatol ;14(10)1510-1, 2016

Taavela JV, Popp A, Kurppa KA, Mäki MJ
Response to Kurien et al.
Am J Gastroenterol ;111(8)1206-7, 2016

Laurikka P, Salmi T, Collin P, Huhtala H, Mäki M, Kaukinen K, Kurppa K
Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet.
Nutrients ;2016

Saukkonen J, Kaukinen K, Koivisto AM, Mäki M, Laurila K, Sievänen H, Collin P, Kurppa K
Clinical Characteristics and the Dietary Response in Celiac Disease Patients Presenting With or Without Anemia.
J Clin Gastroenterol ;2016

Taavela J, Popp A, Korponay-Szabo IR, Ene A, Vornanen M, Saavalainen P, Lähdeaho ML, Ruuska T, Laurila K, Parvan A, Anca I, Kurppa K, Mäki M
A Prospective Study on the Usefulness of Duodenal Bulb Biopsies in Celiac Disease Diagnosis in Children: Urging Caution.
Am J Gastroenterol ;111(1)124-33, 2016

Recent publications (Matti Korppi):

Mecklin M, Heikkilä P, Korppi M
Low age, low birthweight and congenital heart disease are risk factors for intensive care in infants with bronchiolitis.
Acta Paediatr ;106(12)2004-2010, 2017

Sokuri P, Heikkilä P, Korppi M
National high-flow nasal cannula and bronchiolitis survey highlights need for further research and evidence-based guidelines.
Acta Paediatr ;106(12)1998-2003, 2017

Haataja P, Korhonen P, Ojala R, Hirvonen M, Korppi M, Gissler M, Luukkaala T, Tammela O
Hospital admissions for lower respiratory tract infections in children born moderately/late preterm.
Pediatr Pulmonol ;2017

Husby A, Pasanen A, Waage J, Sevelsted A, Hodemaekers H, Janssen R, Karjalainen MK, Stokholm J, Chawes BL, Korppi M, Wennergren G, Heinzmann A, Bont L, Bisgaard H, Bønnelykke K
CDHR3 gene variation and childhood bronchiolitis.
J Allergy Clin Immunol ;140(5)1469-1471.e7, 2017

Liehu-Martiskainen M, Korppi M, Teräsjärvi J, Vuononvirta J, Huhtala H, Nuolivirta K, Kröger L, Peltola V, Pöyhönen L, He Q
Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette-Guérin vaccination.
Acta Paediatr ;106(11)1837-1841, 2017

Salmivesi S, Paassilta M, Huhtala H, Nieminen R, Moilanen E, Korppi M
Elevated serum adipsin may predict unsuccessful treatment for cows' milk allergy but other biomarkers do not.
Acta Paediatr ;2017

Backman K, Ollikainen H, Piippo-Savolainen E, Nuolivirta K, Korppi M
Asthma and Lung Function in Adulthood after a Viral Wheezing Episode in Early Childhood.
Clin Exp Allergy ;2017

Korppi M, Teräsjärvi J, Liehu-Martiskainen M, Lauhkonen E, Vuononvirta J, Nuolivirta K, Kröger L, Pöyhönen L, Karjalainen MK, He Q
Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination.
Sci Rep ;7(1)11691, 2017

Elenius V, Bergroth E, Koponen P, Remes S, Piedra PA, Espinola JA, Korppi M, Camargo CA, Jartti T
Marked variability observed in inpatient management of bronchiolitis in three Finnish hospitals.
Acta Paediatr ;106(9)1512-1518, 2017

Törmänen S, Korppi M, Teräsjärvi J, Vuononvirta J, Koponen P, Helminen M, He Q, Nuolivirta K
Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis.
Sci Rep ;7(1)2956, 2017

Holster A, Teräsjärvi J, Lauhkonen E, Törmänen S, Helminen M, Koponen P, Korppi M, Peltola V, He Q, Nuolivirta K
IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy.
Allergol Int ;2017

Kivistö JE, Protudjer JL, Karjalainen J, Bergström A, Korppi M
Trends in paediatric asthma hospitalisations - differences between neighbouring countries.
Thorax ;2017

Korppi M
The role of rhinoviruses is overestimated in the aetiology of community-acquired pneumonia in children.
Acta Paediatr ;106(3)363-365, 2017

Teräsjärvi J, Hakanen A, Korppi M, Nuolivirta K, Gröndahl-Yli-Hannuksela K, Mertsola J, Peltola V, He Q
Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis.
Sci Rep ;2017

Nieminen O, Korppi M, Helminen M
Healthcare costs doubled when children had urinary tract infections caused by extended-spectrum β-lactamase-producing bacteria.
Acta Paediatr ;106(2)327-333, 2017

Pöyhönen L, Kröger L, Huhtala H, Mäkinen J, Nuolivirta K, Mertsola J, He Q, Korppi M
Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-γ and IL-12 in BCG Osteitis Survivors R1.
Pediatr Infect Dis J ;36(2)135-139, 2017

Pasanen A, Karjalainen MK, Bont L, Piippo-Savolainen E, Ruotsalainen M, Goksör E, Kumawat K, Hodemaekers H, Nuolivirta K, Jartti T, Wennergren G, Hallman M, Rämet M, Korppi M
Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.
Sci Rep ;2017

Korppi M, Nuolivirta K, Lauhkonen E, Holster A, Teräsjärvi J, Vuononvirta J, Helminen M, He Q, Koponen P
IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.
Pediatr Pulmonol ;52(1)14-20, 2017

Spichak TV, Yatsyshina SB, Кatosova LК, Кim SS, Korppi MO
Is the role of rhinoviruses as causative agents of pediatric community-acquired pneumonia over-estimated?
Eur J Pediatr ;175(12)1951-1958, 2016

Heikkilä P, Forma L, Korppi M
High-flow oxygen therapy is more cost-effective for bronchiolitis than standard treatment-A decision-tree analysis.
Pediatr Pulmonol ;51(12)1393-1402, 2016

Korppi M, Heikkilä P
High-flow oxygen therapy: Don't forget warming, humidification and changed airway pressure.
Pediatr Int ;58(10)1094-1095, 2016

Heikkilä P, Korppi M
Nebulised hypertonic saline inhalations do not shorten hospital stays in infants with bronchiolitis.
Acta Paediatr ;105(9)1036-8, 2016

Nuolivirta K, Törmänen S, Teräsjärvi J, Vuononvirta J, Koponen P, Korppi M, Helminen M, Peltola V, He Q
Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism.
Sci Rep ;2016

Pöyhönen L, Kröger L, Huhtala H, Mäkinen J, Mertsola J, Martinez-Barricarte R, Casanova JL, Bustamante J, He Q, Korppi M
Interferon-gamma-dependent Immunity in Bacillus Calmette-Guérin Vaccine Osteitis Survivors.
Pediatr Infect Dis J ;35(6)690-4, 2016

Bergroth E, Aakula M, Korppi M, Remes S, Kivistö JE, Piedra PA, Camargo CA, Jartti T
Post-bronchiolitis Use of Asthma Medication: A Prospective 1-year Follow-up Study.
Pediatr Infect Dis J ;35(4)363-8, 2016

Laaksonen N, Rintamäki L, Korppi M
Pneumococcal vaccinations effectively prevent blood culture-negative infections that resemble occult pneumococcal bacteraemia or bacteraemic pneumococcal pneumonia at one to 36 months of age.
Acta Paediatr ;105(12)1487-1492, 2016

Korppi M
Asthma after bronchiolitis: The outcome and risk factors depend on the age definition of bronchiolitis.
Pediatr Pulmonol ;51(12)1274-1275, 2016

Korppi M, Kivistö J, Koponen P, Lehtinen P, Remes S, Piippo-Savolainen E, Piedra PA, Espinola JA, Camargo CA, Jartti T
Absence of Bordetella pertussis Among Infants Hospitalized for Bronchiolitis in Finland, 2008-2010.
Pediatr Infect Dis J ;35(2)219-21, 2016

Salmivesi S, Paassilta M, Huhtala H, Nieminen R, Moilanen E, Korppi M
Changes in biomarkers during a six-month oral immunotherapy intervention for cow's milk allergy.
Acta Paediatr ;105(11)1349-1354, 2016

Lauhkonen E, Koponen P, Nuolivirta K, Helminen M, Paassilta M, Toikka J, Korppi M
Following up infant bronchiolitis patients provided new evidence for and against the united airway disease hypothesis.
Acta Paediatr ;105(11)1355-1360, 2016

Korppi M, Seuri R
[When is chest radiography indicated in a child?].
Duodecim ;132(1)71-5, 2016

Lauhkonen E, Koponen P, Vuononvirta J, Teräsjärvi J, Nuolivirta K, Toikka JO, Helminen M, He Q, Korppi M
Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis.
PLoS One ;11(1)e0146526, 2016

Backman K, Piippo-Savolainen E, Ollikainen H, Pelli M, Koskela H, Korppi M
Long-term effects of pneumococcal colonization during early childhood wheezing.
Pediatr Int ;58(9)831-5, 2016

Korppi M, Heikkilä P
Randomised controlled studies are needed to evaluate the use of high-flow nasal cannula therapy in bronchiolitis.
Acta Paediatr ;105(8)871-3, 2016

Lohi O, Helminen M, Korppi M
Audits show that specialist paediatric training programmes are sensitive to medical, staffing and economic changes.
Acta Paediatr ;105(6)701-4, 2016

Pöyhönen L, Pauniaho SL, Kröger L, Korppi M
Orthopedic Complications in Former Bacillus Calmette-Guérin Osteitis Patients.
Pediatr Infect Dis J ;35(5)579-80, 2016

Kunnamo A, Korppi M, Helminen M
Tonsillitis in children: unnecessary laboratory studies and antibiotic use.
World J Pediatr ;12(1)114-7, 2016

Paassilta M, Salmivesi S, Mäki T, Helminen M, Korppi M
Children who were treated with oral immunotherapy for cows' milk allergy showed long-term desensitisation seven years later.
Acta Paediatr ;105(2)215-9, 2016

Tapiainen T, Launonen S, Renko M, Saxen H, Salo E, Korppi M, Kainulainen L, Heiskanen-Kosma T, Lindholm L, Vuopio J, Huotari T, Rusanen J, Uhari M
Invasive Group A Streptococcal Infections in Children: A Nationwide Survey in Finland.
Pediatr Infect Dis J ;35(2)123-8, 2016

Korppi M
What are evidence-based guidelines and what are they not?
Acta Paediatr ;105(1)11-2, 2016

Tapiainen T, Aittoniemi J, Immonen J, Jylkkä H, Meinander T, Nuolivirta K, Peltola V, Salo E, Seuri R, Walle SM, Korppi M
Finnish guidelines for the treatment of community-acquired pneumonia and pertussis in children.
Acta Paediatr ;105(1)39-43, 2016

Tapiainen T, Aittoniemi J, Immonen J, Jylkkä H, Meinander T, Nuolivirta K, Peltola V, Salo E, Seuri R, Walle SM, Korppi M
Finnish guidelines for the treatment of laryngitis, wheezing bronchitis and bronchiolitis in children.
Acta Paediatr ;105(1)44-9, 2016

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