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university of tampere: faculty of medicine and life sciences: research:
Faculty of Medicine and Life SciencesUniversity of TampereFaculty of Medicine and Life Sciences


Heikki Hyöty valokuva.jpgVirology




Heikki Hyöty, M.D., Ph.D.

puh. +385 (0)50 516 8480

Link to publications




Hanna Honkanen, M.Sc. +385 (0)50 318 6284
Jutta Laiho, M.Sc. +385 (0)50 318 6338
Anita Kondrashova, M.D. +385 (0)50 318 6284
Laura Korhonen, M.D. +385 (0)50 525 5889
Maria Lönnrot, M.D., Ph.D. +385 (0)50 466 2671
Noora Nurminen, M.Sc. +385 (0)50 318 6284
Maarit Oikarinen, M.Sc. +385 (0)50 318 6338
Sami Oikarinen, M.Sc. +385 (0)50 318 6295
Tapio Seiskari, M.D. +385 (0)50 375 5852
Amirbabak Sioofy-Khojine, D.V.M., Ph.D. +385 (0)50 318 6338
Hanna Viskari, M.D.  +385 (0)3 311 611

Project manager:

Leena Puustinen, M.Sc. +358 (0)50 318 6295

 Leikattu Mervi pipetoi.jpg


Tel. +358 (0)50 318 6262

Jalonen Eveliina
Karjalainen Anne
Kekäläinen Mervi
Keränen Pekka
Kuusela Tanja
Lehtonen Jussi
Ovaskainen Maria
Tolvanen Eeva


Research projects / Collaborators:



Uusimmat julkaisut:

Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H
Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.
Clin Exp Allergy ;2018

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M
Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).
Sci Rep ;8(1)10635, 2018

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Cell Host Microbe ;24(1)146-154.e4, 2018

Nurminen N, Lin J, Grönroos M, Puhakka R, Kramna L, Vari HK, Viskari H, Oikarinen S, Roslund M, Parajuli A, Tyni I, Cinek O, Laitinen O, Hyöty H, Sinkkonen A
Nature-derived microbiota exposure as a novel immunomodulatory approach.
Future Microbiol ;2018

Lind A, Lynch KF, Lundgren M, Lernmark Å, Almgren P, Ramelius A, Puustinen L, Hyöty H, Lundstig A
First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age.
J Reprod Immunol ;2018

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H
Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.
Diabetologia ;61(5)1193-1202, 2018

Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H
Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.
Pediatr Diabetes ;19(3)398-402, 2018

Grönroos M, Parajuli A, Laitinen OH, Roslund MI, Vari HK, Hyöty H, Puhakka R, Sinkkonen A
Short-term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota.
Microbiologyopen ;2018

Laitinen OH, Svedin E, Kapell S, Hankaniemi MM, Larsson PG, Domsgen E, Stone VM, Määttä JAE, Hyöty H, Hytönen VP, Flodström-Tullberg M
pro protease antibodies for virus detection and discovery of pathogenic mechanisms.
J Virol Methods ;2018

Ponsonby AL, Pezic A, Cameron FJ, Rodda C, Kemp AS, Carlin JB, Hyoty H, Sioofy-Khojine A, Dwyer T, Ellis JA, Craig ME
Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices.
PLoS One ;13(4)e0193992, 2018

Cinek O, Mazankova K, Kramna L, Odeh R, Alassaf A, Ibekwe MU, Ahmadov G, Mekki H, Abdullah MA, Elmahi BME, Hyöty H, Rainetova P
Quantitative CrAssphage real-time PCR assay derived from data of multiple geographically distant populations.
J Med Virol ;90(4)767-771, 2018

Roslund MI, Grönroos M, Rantalainen AL, Jumpponen A, Romantschuk M, Parajuli A, Hyöty H, Laitinen O, Sinkkonen A
Half-lives of PAHs and temporal microbiota changes in commonly used urban landscaping materials.
PeerJ ;2018

Parajuli A, Grönroos M, Siter N, Puhakka R, Vari HK, Roslund MI, Jumpponen A, Nurminen N, Laitinen OH, Hyöty H, Rajaniemi J, Sinkkonen A
Urbanization Reduces Transfer of Diverse Environmental Microbiota Indoors.
Front Microbiol ;2018

Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M
A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Diabetologia ;61(2)476-481, 2018

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.
Diabetologia ;61(2)381-388, 2018

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH
A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.
Sci Rep ;8(1)33, 2018

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H
Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.
Diabetologia ;61(1)203-209, 2018

Parajuli A, Grönroos M, Kauppi S, Płociniczak T, Roslund MI, Galitskaya P, Laitinen OH, Hyöty H, Jumpponen A, Strömmer R, Romantschuk M, Hui N, Sinkkonen A
The abundance of health-associated bacteria is altered in PAH polluted soils-Implications for health in urban areas?
PLoS One ;12(11)e0187852, 2017

Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H
Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.
Pediatr Diabetes ;18(7)588-598, 2017

Hankaniemi MM, Laitinen OH, Stone VM, Sioofy-Khojine A, Määttä JAE, Larsson PG, Marjomäki V, Hyöty H, Flodström-Tullberg M, Hytönen VP
Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.
Vaccine ;35(30)3718-3725, 2017

Lin J, Kramna L, Autio R, Hyöty H, Nykter M, Cinek O
Vipie: web pipeline for parallel characterization of viral populations from multiple NGS samples.
BMC Genomics ;18(1)378, 2017

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
Diabetologia ;60(3)424-431, 2017

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia ;60(4)753-755, 2017

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M
Correction: B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.
PLoS One ;12(2)e0172078, 2017

Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K
Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes.
Oncotarget ;8(8)12620-12636, 2017

Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T
Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.
Diabetes ;66(2)437-447, 2017

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