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university of tampere: tampere center for child health research: research: pediatric neurology:
Tampere Center for Child Health ResearchUniversity of TampereTampere Center for Child Health Research
Tampere Center for Child Health Research

Rehabilitation and Neurological / Neuropsychological Development Research

Botulinum toxin-A (BTX-A) Treatment in Children with Idiopathic Toe-walking and Cerebral Palsy (CP)

Heli Sätilä, MD, PhD (heli.satila@khshp.fi)

The aim is to discover whether different injection techniques or varying doses in the management of spasticity in CP in upper and lower extremities have differences in impact on functional and impairment level. Also, we are studying how suitable and effective BTXA is when treating idiopathic toe-walking with normal children compared to conservative treatment.

 

Children with Cerebral Palsy (CP): neurocognitive and neurophysiological correlates

Silja Pirilä, PhD, docent (silja.pirila@uta.fi)

The aim of the project is to investigate neurocognitive correlates of posterior white matter damage causing spastic type of cerebral palsy. Research questions concern relationships between intelligence, attention, executive functions, brain lesion type, and severity. So far,by using clinical neuropsychological tests and electrophysiological measures, we have shown that children with spastic type of unilateral or bilateral CP show inefficient performance on a variety of executive function tasks with mean reaction times and errors as the main dependent variables. However, the poor performance is not caused by their cognitive processes, nor characteristics of motor presetting or motor planning, but it is an outcome of inefficient motor execution system. The project is continuing to explore the cognitive indices and the motor processing apart by using neurophysiological measures in children and adolescents with CP.     

 

Neonatal Hypoglycemia and Neurological Outcome

Mikael Raisio, MD (mikael.raisio@uta.fi)

Glucose is essential for the normal functioning of neurons and it is therefore the most important metabolic substrate for fast growing central nervous system in neonates. Neonatal hypoglycemia is currently believed to be a risk factor for abnormal brain development and the long-term neurocognitive development. In this study, all children who were born in Tampere University Hospital (appr. 5 000 annual deliveries) during years 1994 – 1995, were over 35 weeks of gestational age and had their blood glucose level followed during neonatal period, will be assessed in order to evaluate their neurocognitive functioning and motor performance at the age of 8 – 9 years. The aim of then study is to find out what is the safe glucose level in the respect of long-term neurological development and to find out the possible correlation between neonatal glucose level and later neurocognitive development.

 

 
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