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Faculty of Social SciencesUniversity of TampereFaculty of Social Sciences

Omar Okasha MD, MPH

Project Summary

Pneumococcal disease among adults after routine infant conjugate vaccination in Finland – implications for adult vaccination. THL

Streptococcus pneumoniae (SP) causes a group of severe infections collectively known as Invasive Pneumococcal Disease (IPD); it also causes common respiratory tract infections such as pneumonia. These clinical syndromes are associated with substantial healthcare burden including hospitalizations, physician-visits, antimicrobial use and sick days – particularly the elderly. Two vaccines against selected serotypes of SP are currently used in infant immunization programs across the globe: the 10- and 13-valent Pneumococcal Conjugate Vaccines (PCV10 and PCV13, respectively). PCV10 was introduced in the Finnish National Vaccination Program (NVP) in September 2010.

The goal of the studies under this project is to evaluate the indirect impact of the Finnish national infant PCV program on IPD and pneumonia in adults. Emphasis is put on underlying medical conditions as risk factors for pneumococcal disease, including co-occurrence of multiple simultaneous risk factors. The studies are conducted at national level using register-linkage strategy, and they include all adults 18 years of age. Various study designs and analytical methods are used, including interrupted time-series analyses with potential outcomes approach, population-based cohort analyses, and case-control studies.

The studies are part of the comprehensive evaluation program ”Monitoring the population effectiveness and safety of pneumococcal conjugate vaccination in the Finnish national vaccination programme”, which is carried out by the National Institute for Health and Welfare, Finland. Additionally, the studies are part of Work Package 3 (WP3) of the Integrated Monitoring of Vaccines in Europe (I-MOVE+) project, a consortium of 26 partners from 15 EU/EEA States, which is funded by the European Commission (H2020): http://www.i-moveplus.eu/wp3.

 

 
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